>P51948 MDDQGCPRCK TTKYRNPSLK LMVNVCGHTL CESCVDLLFV RGAGNCPECG TPLRKSNFRV QLFEDPTVDK EVEIRKKVLK IYNKREEDFP SLREYNDFLE EVEEIVFNLT NNVDLDNTKK KMEIYQKENK DVIQKNKLKL TREQEELEEA LEVERQENEQ RRLFIQKEEQ LQQILKRKNK QAFLDELESS DLPVALLLAQ HKDRSTQLEM QLEKPKPVKP VTFSTGIKMG QHISLAPIHK LEEALYEYQP LQIETYGPHV PELEMLGRLG YLNHVRAASP QDLAGGYTSS LACHRALQDA FSGLFWQPS
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 1 | 309 | Family | Cdk-activating kinase assembly factor MAT1/Tfb3 | IPR004575 | TIGR00570 |
| 1 | 309 | Family | Cdk-activating kinase assembly factor MAT1/Tfb3 | IPR004575 | PIRSF003338 |
| 1 | 65 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | IPR013083 | G3DSA:3.30.40.10 |
| 3 | 50 | Domain | Zinc finger, RING-type | IPR001841 | PF17121 |
| 6 | 49 | Domain | Zinc finger, RING-type | IPR001841 | PS50089 |
| 6 | 49 | Domain | Zinc finger, RING-type | IPR001841 | SM00184 |
| 26 | 35 | Conserved_site | Zinc finger, RING-type, conserved site | IPR017907 | PS00518 |
| 53 | 250 | Domain | Cdk-activating kinase assembly factor MAT1, centre | IPR015877 | PF06391 |
| 142 | 161 | Conserved_site | Ubiquitin interacting motif | IPR003903 | PS50330 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0006355 | regulation of DNA-templated transcription | Biological Process | IEA | GO_REF:0000107 |
| GO:0007512 | adult heart development | Biological Process | IEA | GO_REF:0000107 |
| GO:0021591 | ventricular system development | Biological Process | IEA | GO_REF:0000107 |
| GO:0051592 | response to calcium ion | Biological Process | IEA | GO_REF:0000107 |
| GO:0000082 | G1/S transition of mitotic cell cycle | Biological Process | IEA | GO_REF:0000107 |
| GO:0006289 | nucleotide-excision repair | Biological Process | IEA | GO_REF:0000002 |
| GO:0043066 | negative regulation of apoptotic process | Biological Process | IEA | GO_REF:0000107 |
| GO:0048661 | positive regulation of smooth muscle cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0051301 | cell division | Biological Process | IEA | GO_REF:0000043 |
| GO:0006281 | DNA repair | Biological Process | IBA | GO_REF:0000033 |
| GO:0006357 | regulation of transcription by RNA polymerase II | Biological Process | IBA | GO_REF:0000033 |
| GO:0006367 | transcription initiation at RNA polymerase II promoter | Biological Process | IDA | PMID:8692841 |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle | Biological Process | IDA | PMID:23622515 |
| GO:0005634 | nucleus | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005654 | nucleoplasm | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005675 | transcription factor TFIIH holo complex | Cellular Component | IEA | GO_REF:0000002 |
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | Cellular Component | IDA | PMID:23622515 |
| GO:0000439 | transcription factor TFIIH core complex | Cellular Component | IDA | PMID:8692841 |
| GO:0070516 | CAK-ERCC2 complex | Cellular Component | IDA | PMID:8692841 |
| GO:0070985 | transcription factor TFIIK complex | Cellular Component | IDA | PMID:8692841 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity | Molecular Function | IEA | GO_REF:0000002 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:10801852 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL4594350 | ChEMBL | 8.89 | — | — | C=C(F)C(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(Cl)c24)C3)C[C@@H]1CC#N |
| E3 Binder | CHEMBL4799586 | ChEMBL | 6.7 | — | — | C#Cc1cnc(N[C@H]2CCCNC2)nc1-c1cn(C)c2ccccc12 |
| E3 Binder | CHEMBL4787787 | ChEMBL | 6.0 | — | — | C=C(CC)C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4785125 | ChEMBL | 7.0 | — | — | C=CC(=O)N(C)c1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4641226 | ChEMBL | 6.34 | — | — | C=CC(=O)N1CCC(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)CC1 |
| E3 Binder | CHEMBL4776207 | ChEMBL | 7.7 | — | — | C=CC(=O)N1CCC(CO[C@H]2CNC[C@@H](Nc3ncc(C(F)(F)F)c(-c4c[nH]c5c(S(C)(=O)=O)cccc45)n3)C2)CC1 |
| E3 Binder | CHEMBL4790981 | ChEMBL | 7.0 | — | — | C=CC(=O)N1CCCc2cc(C(=O)N3CC[C@@H](Nc4ncc5ccccc5n4)C3)ccc21 |
| E3 Binder | CHEMBL4778372 | ChEMBL | 7.0 | — | — | C=CC(=O)N1CCOc2cc(C(=O)N3CC[C@@H](Nc4ncc5ccccc5n4)C3)ccc21 |
| E3 Binder | CHEMBL4745351 | ChEMBL | 6.93 | — | — | C=CC(=O)Nc1cc(F)c(N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1C |
| E3 Binder | CHEMBL4754972 | ChEMBL | 6.39 | — | — | C=CC(=O)Nc1cc(OC)c(N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1C |
| E3 Binder | CHEMBL4644893 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CCCC(C(=O)Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 |
| E3 Binder | CHEMBL4746581 | ChEMBL | 6.57 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(Br)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4758566 | ChEMBL | 6.04 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4785808 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3cc4ccccc4cn3)C2)cc1 |
| E3 Binder | CHEMBL4800375 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4c(F)cccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4782773 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(C)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4792917 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(Cl)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4780671 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(F)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4781015 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(F)ccc4n3)C2)cc1C |
| E3 Binder | CHEMBL4795793 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(F)ccc4n3)C2)cc1F |
| E3 Binder | CHEMBL4787763 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(=O)[nH]c4n3)C2)cc1 |
| E3 Binder | CHEMBL4777456 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(=O)n(C(C)C)c4n3)C2)cc1 |
| E3 Binder | CHEMBL4790543 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C#N)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4782971 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C(=O)N(C)C)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4786606 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C(=O)O)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4781470 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C(N)=O)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4789684 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4779975 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(Cl)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4788614 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(F)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4796897 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(OC)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4793822 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(S(C)(=O)=O)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4795046 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(S(C)(=O)=O)cc4n3)C2)cc1C |
| E3 Binder | CHEMBL4785116 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cccc(F)c4n3)C2)cc1 |
| E3 Binder | CHEMBL4798225 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)c(C)c1 |
| E3 Binder | CHEMBL4798870 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)c(OC)c1 |
| E3 Binder | CHEMBL4784867 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4787637 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1C |
| E3 Binder | CHEMBL4798537 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1Cl |
| E3 Binder | CHEMBL4798936 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1F |
| E3 Binder | CHEMBL4781784 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1OC |
| E3 Binder | CHEMBL4788834 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cn1 |
| E3 Binder | CHEMBL4780901 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccncc4n3)C2)cc1 |
| E3 Binder | CHEMBL4644643 | ChEMBL | 6.21 | — | — | C=CC(=O)Nc1ccc(C(=O)N2C[C@H](Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)CC[C@@H]2C)cc1 |
| E3 Binder | CHEMBL4780675 | ChEMBL | 6.0 | — | — | C=CC(=O)Nc1ccc(C(=O)N2C[C@H](Nc3ncc4ccccc4n3)[C@@H](F)C2)cc1 |
| E3 Binder | CHEMBL4450322 | ChEMBL | 8.01 | — | — | C=CC(=O)Nc1ccc(C(=O)Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)cc1 |
| E3 Binder | CHEMBL4434871 | ChEMBL | 8.12 | — | — | C=CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3n[nH]c4c3CN(C(=O)N[C@H](CN(C)C)c3ccccc3)C4(C)C)c2)cc1 |
| E3 Binder | CHEMBL4744880 | ChEMBL | 6.79 | — | — | C=CC(=O)Nc1ccc(N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1 |
| E3 Binder | CHEMBL4746786 | ChEMBL | 6.36 | — | — | C=CC(=O)Nc1ccc(N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4648005 | ChEMBL | 6.25 | — | — | C=CC(=O)Nc1ccc(NC2CCCC(Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 |
| E3 Binder | CHEMBL4758407 | ChEMBL | 6.06 | — | — | C=CC(=O)Nc1ccc(O[C@@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)c(F)c1 |
| E3 Binder | CHEMBL4780821 | ChEMBL | 6.23 | — | — | C=CC(=O)Nc1ccc(O[C@@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1 |
| E3 Binder | CHEMBL4778791 | ChEMBL | 7.0 | — | — | C=CC(=O)Nc1cccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)c1 |
| E3 Binder | CHEMBL4787897 | ChEMBL | 7.0 | — | — | C=CS(=O)(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4797958 | ChEMBL | 7.0 | — | — | CC#CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4870188 | ChEMBL | 7.54 | — | — | CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)c2)CC1 |
| E3 Binder | CHEMBL4290222 | ChEMBL | 6.29 | — | — | CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C5CCOCC5)c34)CC2)CC1 |
| E3 Binder | CHEMBL5079342 | ChEMBL | 6.48 | — | — | CC(=O)N1CCN(c2ccc(F)c(Nc3cc4nc([C@](C)(O)C5CCN(C)CC5)ccc4cn3)c2)CC1 |
| E3 Binder | CHEMBL4856641 | ChEMBL | 6.27 | — | — | CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4c(C)[nH]c5ccccc45)n3)cc2)CC1 |
| E3 Binder | CHEMBL4855435 | ChEMBL | 6.37 | — | — | CC(=O)N1CCN(c2ccc(Nc3ncc(C#N)c(-c4c[nH]c5ccccc45)n3)cc2)CC1 |
| E3 Binder | CHEMBL4784604 | ChEMBL | 7.7 | — | — | CC(=O)NCc1cccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1 |
| E3 Binder | CHEMBL4754081 | ChEMBL | 6.26 | — | — | CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(F)cn2)C1 |
| E3 Binder | CHEMBL4780924 | ChEMBL | 7.7 | — | — | CC(=O)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL296468 | ChEMBL | 7.21 | 56H | — | CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 |
| E3 Binder | CHEMBL4800597 | ChEMBL | 7.7 | — | — | CC(C)(O)CCc1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4777468 | ChEMBL | 7.7 | — | — | CC(C)(O)Cn1cc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)cn1 |
| E3 Binder | CHEMBL4796697 | ChEMBL | 7.7 | — | — | CC(C)C1CC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL4790200 | ChEMBL | 7.7 | — | — | CC(C)CN1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL4790299 | ChEMBL | 7.7 | — | — | CC(C)N1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL5080123 | ChEMBL | 6.11 | — | — | CC(C)Nc1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cn1 |
| E3 Binder | CHEMBL5070707 | ChEMBL | 6.79 | — | — | CC(C)Oc1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cc1C#N |
| E3 Binder | CHEMBL5083778 | ChEMBL | 6.44 | — | — | CC(C)Oc1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cn1 |
| E3 Binder | CHEMBL4786016 | ChEMBL | 7.7 | — | — | CC(C)S(=O)(=O)c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4792784 | ChEMBL | 7.7 | — | — | CC(C)[C@@H]1CC[C@H](Nc2nccc(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL4789898 | ChEMBL | 6.7 | — | — | CC(C)[C@H]1CC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL3940387 | ChEMBL | 6.61 | — | — | CC(C)c1c2cc(-c3ccnc(N[C@H]4CC[C@H](NC5CCOCC5)CC4)n3)ccc2nn1C |
| E3 Binder | CHEMBL5080361 | ChEMBL | 6.98 | — | — | CC(C)c1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cc1C#N |
| E3 Binder | CHEMBL5090019 | ChEMBL | 6.83 | — | — | CC(C)c1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cn1 |
| E3 Binder | CHEMBL426972 | ChEMBL | 6.2 | — | — | CC(C)c1cnc(NC(=O)Cc2ccccc2)s1 |
| E3 Binder | CHEMBL4792063 | ChEMBL | 7.7 | — | — | CC(C)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4785067 | ChEMBL | 7.7 | — | — | CC(C)c1cnc(N[C@H]2CCCNC2)nc1-c1n[nH]c2nc(C#N)ccc12 |
| E3 Binder | CHEMBL4519886 | ChEMBL | 6.51 | — | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NCC3CCNCC3)nc12 |
| E3 Binder | CHEMBL1801932 | ChEMBL | 6.87 | X2H | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 |
| E3 Binder | CHEMBL4459754 | ChEMBL | 7.39 | I73 | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@@H]3CCNC[C@H]3O)nc12 |
| E3 Binder | CHEMBL4472515 | ChEMBL | 6.16 | — | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@H]3CCCC[C@@H]3O)nc12 |
| E3 Binder | CHEMBL4553241 | ChEMBL | 7.85 | — | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@]3(CO)CCNC3)nc12 |
| E3 Binder | CHEMBL4471850 | ChEMBL | 7.75 | X50 | — | CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@]3(O)CCNC[C@H]3O)nc12 |
| E3 Binder | CHEMBL4540226 | ChEMBL | 6.91 | FCQ | — | CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(SCCN)nc12 |
| E3 Binder | CHEMBL4790771 | ChEMBL | 6.7 | — | — | CC(C)n1cc(-c2nc(N[C@H]3CCCNC3)ncc2Cl)c2ccccc21 |
| E3 Binder | CHEMBL4798401 | ChEMBL | 6.7 | — | — | CC(O)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL3884319 | ChEMBL | 6.1 | — | — | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 |
| E3 Binder | CHEMBL4782475 | ChEMBL | 6.7 | — | — | CC1(C)CCNC[C@@H]1Nc1ncc(C(F)(F)F)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4786596 | ChEMBL | 6.7 | — | — | CC1(C)CCNC[C@H]1Nc1ncc(C(F)(F)F)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4791645 | ChEMBL | 7.7 | — | — | CC1(C)CC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4cc(C#N)ccc34)n2)CN1 |
| E3 Binder | CHEMBL4779583 | ChEMBL | 7.7 | — | — | CC1(C)CNC[C@@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4cc(S(C)(=O)=O)ccc34)n2)C1 |
| E3 Binder | CHEMBL4797704 | ChEMBL | 6.7 | — | — | CC1(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CCCNC1 |
| E3 Binder | CHEMBL4787747 | ChEMBL | 7.7 | — | — | CC1CCC(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL4796032 | ChEMBL | 7.7 | — | — | CC1NCCCC1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4780631 | ChEMBL | 6.7 | — | — | CCC(=O)N[C@H]1CNC[C@@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4c(S(C)(=O)=O)cccc34)n2)C1 |
| E3 Binder | CHEMBL4799081 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3cc4ccccc4cn3)C2)cc1 |
| E3 Binder | CHEMBL4790922 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(C)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4779816 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(Cl)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4786660 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(F)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4798847 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(=O)[nH]c4n3)C2)cc1 |
| E3 Binder | CHEMBL4800360 | ChEMBL | 7.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(=O)n(C(C)C)c4n3)C2)cc1 |
| E3 Binder | CHEMBL4799173 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C#N)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4786179 | ChEMBL | 7.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C(=O)N(C)C)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4785249 | ChEMBL | 7.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(C(=O)O)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4793091 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(Cl)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4781718 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(F)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4796805 | ChEMBL | 7.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(OC)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4796972 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccc(S(C)(=O)=O)cc4n3)C2)cc1 |
| E3 Binder | CHEMBL4787766 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4784593 | ChEMBL | 6.0 | — | — | CCC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccncc4n3)C2)cc1 |
| E3 Binder | CHEMBL4799169 | ChEMBL | 7.7 | — | — | CCCCCc1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4782689 | ChEMBL | 7.7 | — | — | CCCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(S(C)(=O)=O)c(C#N)ccc12 |
| E3 Binder | CHEMBL5079648 | ChEMBL | 6.41 | — | — | CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2n1 |
| E3 Binder | CHEMBL4796485 | ChEMBL | 7.7 | — | — | CCN1C[C@@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4cc(S(C)(=O)=O)ccc34)n2)CC(C)(C)C1 |
| E3 Binder | CHEMBL4783627 | ChEMBL | 7.7 | — | — | CCOP(=O)(OCC)c1ccc2[nH]cc(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c2c1 |
| E3 Binder | CHEMBL4796907 | ChEMBL | 7.7 | — | — | CCOP(=O)(OCC)c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4787580 | ChEMBL | 6.7 | — | — | CCOP(=O)(OCC)c1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c12 |
| E3 Binder | CHEMBL4782858 | ChEMBL | 7.7 | — | — | CCOc1ccccc1-c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4776905 | ChEMBL | 7.7 | — | — | CCP(=O)(CC)c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4784288 | ChEMBL | 7.7 | — | — | CC[C@@H]1CC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL4785594 | ChEMBL | 7.7 | — | — | CC[C@@]1(O)CCN(C(=O)c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)C1 |
| E3 Binder | CHEMBL215919 | ChEMBL | 6.08 | — | — | CC[C@H](CO)Nc1nc(Nc2cccc(-c3ccccn3)c2)c2ncn(C(C)C)c2n1 |
| E3 Binder | CHEMBL4796002 | ChEMBL | 7.7 | — | — | CC[C@]1(O)CCN(C(=O)c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)C1 |
| E3 Binder | CHEMBL5088595 | ChEMBL | 6.71 | — | — | CCc1cc(Nc2cc3nc([C@](C)(O)C4CCN(C)CC4)ccc3cn2)c(F)cn1 |
| E3 Binder | CHEMBL4782860 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(F)c(C#N)ccc12 |
| E3 Binder | CHEMBL4783661 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(S(=O)(=O)C(C)C)cccc12 |
| E3 Binder | CHEMBL4790489 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(S(=O)(=O)O)cccc12 |
| E3 Binder | CHEMBL4794714 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c([S+]([O-])O)cccc12 |
| E3 Binder | CHEMBL4776277 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(S(C)(=O)=O)ccc12 |
| E3 Binder | CHEMBL4782476 | ChEMBL | 6.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccc(C)cc12 |
| E3 Binder | CHEMBL4800180 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4793244 | ChEMBL | 7.7 | — | — | CCc1cnc(N[C@H]2CCCNC2)nc1-c1n[nH]c2ccccc12 |
| E3 Binder | CHEMBL2103840 | ChEMBL | 6.77 | — | — | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 |
| E3 Binder | CHEMBL367625 | ChEMBL | 6.55 | FC8 | — | CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 |
| E3 Binder | CHEMBL4790934 | ChEMBL | 7.0 | — | — | CN(C)C/C=C/C(=O)N(C)c1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4782605 | ChEMBL | 6.0 | — | — | CN(C)C/C=C/C(=O)N1CCCc2cc(C(=O)N3CC[C@@H](Nc4ncc5ccccc5n4)C3)ccc21 |
| E3 Binder | CHEMBL4793627 | ChEMBL | 6.0 | — | — | CN(C)C/C=C/C(=O)N1CCOc2cc(C(=O)N3CC[C@@H](Nc4ncc5ccccc5n4)C3)ccc21 |
| E3 Binder | CHEMBL4784822 | ChEMBL | 6.6 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(Br)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4787545 | ChEMBL | 6.4 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4792618 | ChEMBL | 6.0 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4cc(F)ccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4787903 | ChEMBL | 7.0 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1 |
| E3 Binder | CHEMBL4796640 | ChEMBL | 7.0 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1Cl |
| E3 Binder | CHEMBL4789696 | ChEMBL | 7.0 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)cc1F |
| E3 Binder | CHEMBL4582951 | ChEMBL | 7.89 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N[C@@]2(C)CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4441405 | ChEMBL | 7.32 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N[C@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1 |
| E3 Binder | CHEMBL4436535 | ChEMBL | 8.4 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N[C@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL3603847 | ChEMBL | 8.0 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)cc1 |
| E3 Binder | CHEMBL4748005 | ChEMBL | 7.13 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1 |
| E3 Binder | CHEMBL4753819 | ChEMBL | 6.57 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(O[C@@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)c(F)c1 |
| E3 Binder | CHEMBL4754873 | ChEMBL | 6.92 | — | — | CN(C)C/C=C/C(=O)Nc1ccc(O[C@@H]2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)cc1 |
| E3 Binder | CHEMBL4303287 | ChEMBL | 7.86 | — | — | CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)c1 |
| E3 Binder | CHEMBL1944698 | ChEMBL | 8.52 | — | — | CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 |
| E3 Binder | CHEMBL5087911 | ChEMBL | 6.53 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(C(F)(F)F)c(C#N)cc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5084200 | ChEMBL | 6.14 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(C(F)(F)F)ncc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5080813 | ChEMBL | 6.2 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(C(N)=O)ncc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5077028 | ChEMBL | 7.03 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CC6CCC(C5)O6)c(C#N)cc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5091792 | ChEMBL | 7.02 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CCCC5)ncc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5080566 | ChEMBL | 6.77 | 61U | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CCOCC5)c(C#N)cc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5080866 | ChEMBL | 7.14 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CCOCC5)ccc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5078192 | ChEMBL | 7.11 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(N5CCOCC5)ncc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL5084882 | ChEMBL | 6.14 | — | — | CN1CCC([C@@](C)(O)c2ccc3cnc(Nc4cc(OC5CCC5)ncc4F)cc3n2)CC1 |
| E3 Binder | CHEMBL4777123 | ChEMBL | 7.7 | — | — | CN1CCC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4cc(S(=O)(=O)N5CCC(C)(O)C5)ccc34)n2)C1 |
| E3 Binder | CHEMBL4779648 | ChEMBL | 7.7 | — | — | CN1CCC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4cc(S(C)(=O)=O)ccc34)n2)C1 |
| E3 Binder | CHEMBL4862206 | ChEMBL | 6.85 | — | — | CN1CCN(c2cccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)c2)CC1 |
| E3 Binder | CHEMBL428690 | ChEMBL | 6.29 | CPB | — | CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 |
| E3 Binder | CHEMBL4788987 | ChEMBL | 7.7 | — | — | CNC(=O)[C@@H]1CNC[C@@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL4796263 | ChEMBL | 7.7 | — | — | CNC(=O)[C@H]1CNC[C@@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL564829 | ChEMBL | 6.57 | P48 | — | CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 |
| E3 Binder | CHEMBL388978 | ChEMBL | 7.14 | STU | — | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
| E3 Binder | CHEMBL4781209 | ChEMBL | 7.7 | — | — | COCCN1CCC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL4779588 | ChEMBL | 7.7 | — | — | COCCn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2ccccc21 |
| E3 Binder | CHEMBL4787092 | ChEMBL | 6.7 | — | — | COCCn1cc(-c2nc(N[C@H]3CCCNC3)ncc2Cl)c2ccccc21 |
| E3 Binder | CHEMBL4795638 | ChEMBL | 6.7 | — | — | COCn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2ccc(C#N)nc21 |
| E3 Binder | CHEMBL4797856 | ChEMBL | 7.7 | — | — | COCn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2cccc(C#N)c21 |
| E3 Binder | CHEMBL4576489 | ChEMBL | 6.09 | — | — | CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
| E3 Binder | CHEMBL4465866 | ChEMBL | 6.05 | — | — | CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
| E3 Binder | CHEMBL4795466 | ChEMBL | 7.7 | — | — | CO[C@H]1CCN(C(=O)c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)C1 |
| E3 Binder | CHEMBL4800695 | ChEMBL | 7.0 | — | — | COc1cc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)ccc1NC(=O)/C=C/CN(C)C |
| E3 Binder | CHEMBL4784736 | ChEMBL | 7.0 | — | — | COc1cc(NC(=O)/C=C/CN(C)C)ccc1C(=O)N1CC[C@@H](Nc2ncc3ccccc3n2)C1 |
| E3 Binder | CHEMBL4127826 | ChEMBL | 7.05 | — | — | COc1ccc(C(=O)NC2CCN(c3nccc(Nc4ccc(F)cc4)n3)CC2)cc1 |
| E3 Binder | CHEMBL258805 | ChEMBL | 6.04 | SU9 | — | COc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 |
| E3 Binder | CHEMBL4782746 | ChEMBL | 6.7 | — | — | COc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4778182 | ChEMBL | 7.7 | — | — | CP(C)(=O)c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4794788 | ChEMBL | 7.7 | — | — | CS(=O)(=O)c1ccc2c(-c3nc(N[C@H]4CCCN(C5CC5)C4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4778885 | ChEMBL | 6.7 | — | — | CS(=O)(=O)c1cccn2c([C@H]3CNC[C@@H](Nc4ncc(C(F)(F)F)c(-c5c[nH]c6ccccc56)n4)C3)nnc12 |
| E3 Binder | CHEMBL4442620 | ChEMBL | 7.6 | — | — | C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1C(F)(F)F |
| E3 Binder | CHEMBL4797976 | ChEMBL | 6.7 | — | — | C[C@@H](O)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4796480 | ChEMBL | 7.7 | — | — | C[C@@H]1CCNC[C@@H]1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4777604 | ChEMBL | 7.7 | — | — | C[C@@H]1CCNC[C@H]1Nc1ncc(C(F)(F)F)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4786193 | ChEMBL | 7.7 | — | — | C[C@@H]1CNC[C@@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)C1 |
| E3 Binder | CHEMBL4785776 | ChEMBL | 6.7 | — | — | C[C@H](O)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4800607 | ChEMBL | 7.7 | — | — | C[C@H]1CCNC[C@@H]1Nc1ncc(C(F)(F)F)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4785609 | ChEMBL | 7.7 | — | — | C[C@H]1CCNC[C@@H]1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4788465 | ChEMBL | 6.7 | — | — | C[C@H]1CCNC[C@H]1Nc1ncc(C(F)(F)F)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4790770 | ChEMBL | 7.7 | — | — | C[C@]1(O)CC[C@@H](c2cccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c32)CC1 |
| E3 Binder | CHEMBL4798073 | ChEMBL | 7.7 | — | — | C[C@]1(O)CC[C@H](c2cccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c32)CC1 |
| E3 Binder | CHEMBL4783125 | ChEMBL | 7.7 | — | — | Cc1[nH]c2ccccc2c1-c1nc(N[C@H]2CCCNC2)ncc1Cl |
| E3 Binder | CHEMBL4787373 | ChEMBL | 6.0 | — | — | Cc1cc(C(=O)N2CC[C@@H](Nc3ncc4ccccc4n3)C2)ccc1NC(=O)/C=C/CN(C)C |
| E3 Binder | CHEMBL4788933 | ChEMBL | 7.7 | — | — | Cc1ccc2[nH]cc(-c3nc(N[C@H]4CCCNC4)ncc3Cl)c2c1 |
| E3 Binder | CHEMBL4081756 | ChEMBL | 6.45 | — | — | Cc1cccc(C(=O)N[C@H]2C[C@@H](n3cnc4c(NCc5cccc(Br)c5)ncnc43)C2)n1 |
| E3 Binder | CHEMBL4103221 | ChEMBL | 6.5 | — | — | Cc1cccc(C(=O)N[C@H]2C[C@@H](n3cnc4c(NCc5cccc(Cl)c5)ncnc43)C2)n1 |
| E3 Binder | CHEMBL4791711 | ChEMBL | 6.7 | — | — | Cc1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3CC(C)C)c[nH]c12 |
| E3 Binder | CHEMBL4783735 | ChEMBL | 7.7 | — | — | Cc1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3F)c[nH]c12 |
| E3 Binder | CHEMBL4790718 | ChEMBL | 7.7 | — | — | Cc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL298445 | ChEMBL | 6.78 | CK7 | — | Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1 |
| E3 Binder | CHEMBL3128043 | ChEMBL | 8.15 | 7KC | — | Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 |
| E3 Binder | CHEMBL4788953 | ChEMBL | 7.7 | — | — | Cc1noc([C@H]2CC[C@H](Nc3ncc(C(F)(F)F)c(-c4c[nH]c5cc(C#N)ccc45)n3)CN2)n1 |
| E3 Binder | CHEMBL4786870 | ChEMBL | 7.7 | — | — | Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(N3CCOCC3)cccc12 |
| E3 Binder | CHEMBL4795935 | ChEMBL | 6.7 | — | — | Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccc(N3CCOCC3)cc12 |
| E3 Binder | CHEMBL4792679 | ChEMBL | 7.7 | — | — | Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccncc12 |
| E3 Binder | CHEMBL4777525 | ChEMBL | 6.7 | — | — | Clc1cnc(N[C@H]2CCCNC2)nc1-c1cn(-c2ccccc2)c2ccccc12 |
| E3 Binder | CHEMBL4797244 | ChEMBL | 7.7 | — | — | Clc1cnc(N[C@H]2CCCNC2)nc1-c1cnn2ccccc12 |
| E3 Binder | CHEMBL4778657 | ChEMBL | 7.7 | — | — | Cn1cc(-c2ccc3[nH]cc(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c3c2)cn1 |
| E3 Binder | CHEMBL4791765 | ChEMBL | 7.7 | — | — | Cn1cc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c2cnc(C(F)(F)F)cc21 |
| E3 Binder | CHEMBL4791262 | ChEMBL | 7.7 | — | — | Cn1cc(-c2cccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c23)cn1 |
| E3 Binder | CHEMBL4798932 | ChEMBL | 6.7 | — | — | Cn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2ccc(C#N)nc21 |
| E3 Binder | CHEMBL4784046 | ChEMBL | 7.7 | — | — | Cn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2cccc(C#N)c21 |
| E3 Binder | CHEMBL4781758 | ChEMBL | 7.7 | — | — | Cn1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c2cccc(S(C)(=O)=O)c21 |
| E3 Binder | CHEMBL4789131 | ChEMBL | 7.7 | — | — | Cn1ncc2ccc(-c3ccc4c(-c5nc(N[C@H]6CCCNC6)ncc5C(F)(F)F)c[nH]c4c3)cc21 |
| E3 Binder | CHEMBL4794715 | ChEMBL | 6.7 | — | — | FC(F)(F)Cc1cnc(N[C@H]2CCCNC2)nc1-c1n[nH]c2ccccc12 |
| E3 Binder | CHEMBL4795301 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cc2[nH]cc(-c3ccc4c(-c5nc(N[C@H]6CCCNC6)ncc5C(F)(F)F)c[nH]c4c3)c2cn1 |
| E3 Binder | CHEMBL4781253 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(NC2C3CCC2NC3)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4799487 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@@H]2CNC[C@H](c3nnc4ccccn34)C2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4778051 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@@H]2CNCc3ccccc32)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4779834 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCC3(CCCCC3)NC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4788043 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(-c3ccncc3)cccc12 |
| E3 Binder | CHEMBL4777758 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)cccc12 |
| E3 Binder | CHEMBL4795715 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3ccc4c(c3)OCCO4)ccc12 |
| E3 Binder | CHEMBL4795042 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3ccc4c[nH]nc4c3)ccc12 |
| E3 Binder | CHEMBL4787197 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3ccc4ccncc4c3)ccc12 |
| E3 Binder | CHEMBL4793254 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3ccc4ncsc4c3)ccc12 |
| E3 Binder | CHEMBL4790802 | ChEMBL | 6.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3cccc(Oc4ccccc4)c3)ccc12 |
| E3 Binder | CHEMBL4795267 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3cccc4cnccc34)ccc12 |
| E3 Binder | CHEMBL4779318 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(-c3ccnc4ccccc34)ccc12 |
| E3 Binder | CHEMBL4792958 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(/C=C/c3ccccc3)ccc12 |
| E3 Binder | CHEMBL4786413 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(N3CCCC3)ccc12 |
| E3 Binder | CHEMBL4792193 | ChEMBL | 7.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccc(-c3cn[nH]c3)cc12 |
| E3 Binder | CHEMBL4786320 | ChEMBL | 6.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4781415 | ChEMBL | 6.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CNC[C@@H](c3nnc4ccccn34)C2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4778392 | ChEMBL | 6.7 | — | — | FC(F)(F)c1cnc(N[C@H]2CNCc3ccccc32)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4796874 | ChEMBL | 7.7 | — | — | FC(F)n1cc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)cn1 |
| E3 Binder | CHEMBL4790773 | ChEMBL | 7.7 | — | — | FC(F)n1ccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)n1 |
| E3 Binder | CHEMBL4783994 | ChEMBL | 7.7 | — | — | FCCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 |
| E3 Binder | CHEMBL4786864 | ChEMBL | 7.7 | — | — | F[C@@H]1CCNC[C@H]1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4798775 | ChEMBL | 6.7 | — | — | Fc1cccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1 |
| E3 Binder | CHEMBL4781069 | ChEMBL | 7.7 | — | — | Fc1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3Cl)c[nH]c12 |
| E3 Binder | CHEMBL4781205 | ChEMBL | 7.7 | — | — | Fc1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3Cl)n[nH]c12 |
| E3 Binder | CHEMBL4780112 | ChEMBL | 7.7 | — | — | Fc1cncc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1 |
| E3 Binder | CHEMBL4783754 | ChEMBL | 7.7 | — | — | N#Cc1cc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)ccc1O |
| E3 Binder | CHEMBL4797783 | ChEMBL | 7.7 | — | — | N#Cc1ccc2[nH]cc(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c2c1 |
| E3 Binder | CHEMBL4797260 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1-c1ccnnc1 |
| E3 Binder | CHEMBL4793388 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@@H]4CNCC[C@H]4O)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4795651 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@@H]4CNC[C@@H](F)C4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4785804 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@@H]4CNC[C@H](O)C4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4793843 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@H]4CCC5(CCC5)NC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4789342 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3OC(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4796314 | ChEMBL | 7.7 | — | — | N#Cc1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3SC(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL2402946 | ChEMBL | 6.51 | — | — | NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4O)nc3)c3ncn(C4CCCC4)c3n2)CC1 |
| E3 Binder | CHEMBL4780460 | ChEMBL | 7.7 | — | — | NS(=O)(=O)c1ccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)cc1 |
| E3 Binder | CHEMBL4795015 | ChEMBL | 7.7 | — | — | NS(=O)(=O)c1cccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1 |
| E3 Binder | CHEMBL4764481 | ChEMBL | 6.26 | TO7 | — | Nc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+](=O)[O-] |
| E3 Binder | CHEMBL261720 | ChEMBL | 7.18 | DKI | — | Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=S)Nc1c(F)cccc1F |
| E3 Binder | CHEMBL4791188 | ChEMBL | 7.7 | — | — | Nc1nc2c(-c3ccc4c(-c5nc(N[C@H]6CCCNC6)ncc5C(F)(F)F)c[nH]c4c3)cccc2s1 |
| E3 Binder | CHEMBL4779846 | ChEMBL | 7.7 | — | — | O=C(O)c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1 |
| E3 Binder | CHEMBL4793626 | ChEMBL | 7.7 | — | — | O=C(O)c1cccc2c(-c3nc(N[C@H]4CCCNC4)ncc3Cl)c[nH]c12 |
| E3 Binder | CHEMBL4790437 | ChEMBL | 7.7 | — | — | O=C([C@H]1CC[C@H](Nc2ncc(C(F)(F)F)c(-c3c[nH]c4ccccc34)n2)CN1)N1CC[C@H](O)C1 |
| E3 Binder | CHEMBL4778825 | ChEMBL | 7.7 | — | — | O=C(c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c2c1)N1CCCC1 |
| E3 Binder | CHEMBL4795769 | ChEMBL | 7.7 | — | — | O=C(c1cccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1)N1CCCC1 |
| E3 Binder | CHEMBL4792632 | ChEMBL | 7.7 | — | — | O=C1CCN(C(=O)c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)C1 |
| E3 Binder | CHEMBL4785708 | ChEMBL | 7.7 | — | — | O=C1CC[C@H](Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)CN1 |
| E3 Binder | CHEMBL4787811 | ChEMBL | 7.7 | — | — | O=C1CCc2ccc(-c3ccc4c(-c5nc(N[C@H]6CCCNC6)ncc5C(F)(F)F)c[nH]c4c3)cc2N1 |
| E3 Binder | CHEMBL1276446 | ChEMBL | 6.5 | — | — | O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1 |
| E3 Binder | CHEMBL4795414 | ChEMBL | 7.7 | — | — | O=S1(=O)CCn2cc(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c3cccc1c32 |
| E3 Binder | CHEMBL300389 | ChEMBL | 6.7 | 8II | — | OCCCNc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1 |
| E3 Binder | CHEMBL4795275 | ChEMBL | 7.7 | — | — | OCCc1cccc(-c2ccc3c(-c4nc(N[C@H]5CCCNC5)ncc4C(F)(F)F)c[nH]c3c2)c1 |
| E3 Binder | CHEMBL5088480 | ChEMBL | 7.06 | 65L | — | OCc1ccn(-c2ccc(Nc3cc4nc(OC5CCNCC5)ccc4cn3)c(F)c2)n1 |
| E3 Binder | CHEMBL4777842 | ChEMBL | 7.7 | — | — | O[C@@H]1CCNC[C@H]1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 |
| E3 Binder | CHEMBL4777419 | ChEMBL | 7.7 | — | — | c1ccc2c(-c3nc(N[C@H]4CCCNC4)ncc3C3CC3)c[nH]c2c1 |