VPS41

Details:

UniProt Entry: P49754
Gene: VPS41
Class: RING
Family: RING9
Protein length: 854
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>P49754
MAEAEEQETG SLEESTDESE EEESEEEPKL KYERLSNGVT EILQKDAASC MTVHDKFLAL
GTHYGKVYLL DVQGNITQKF DVSPVKINQI SLDESGEHMG VCSEDGKVQV FGLYSGEEFH
ETFDCPIKII AVHPHFVRSS CKQFVTGGKK LLLFERSWMN RWKSAVLHEG EGNIRSVKWR
GHLIAWANNM GVKIFDIISK QRITNVPRDD ISLRPDMYPC SLCWKDNVTL IIGWGTSVKV
CSVKERHASE MRDLPSRYVE IVSQFETEFY ISGLAPLCDQ LVVLSYVKEI SEKTEREYCA
RPRLDIIQPL SETCEEISSD ALTVRGFQEN ECRDYHLEYS EGESLFYIVS PRDVVVAKER
DQDDHIDWLL EKKKYEEALM AAEISQKNIK RHKILDIGLA YINHLVERGD YDIAARKCQK
ILGKNAALWE YEVYKFKEIG QLKAISPYLP RGDPVLKPLI YEMILHEFLE SDYEGFATLI
REWPGDLYNN SVIVQAVRDH LKKDSQNKTL LKTLAELYTY DKNYGNALEI YLTLRHKDVF
QLIHKHNLFS SIKDKIVLLM DFDSEKAVDM LLDNEDKISI KKVVEELEDR PELQHVYLHK
LFKRDHHKGQ RYHEKQISLY AEYDRPNLLP FLRDSTHCPL EKALEICQQR NFVEETVYLL
SRMGNSRSAL KMIMEELHDV DKAIEFAKEQ DDGELWEDLI LYSIDKPPFI TGLLNNIGTH
VDPILLIHRI KEGMEIPNLR DSLVKILQDY NLQILLREGC KKILVADSLS LLKKMHRTQM
KGVLVDEENI CESCLSPILP SDAAKPFSVV VFHCRHMFHK ECLPMPSMNS AAQFCNICSA
KNRGPGSAIL EMKK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	834	Family	Vacuolar protein sorting-associated protein 41	IPR016902	PIRSF028921
3	846	Family	Vacuolar protein sorting-associated protein Vps41/Vps8	IPR045111	PTHR12616
29	286	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
45	246	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
568	712	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PS50236
571	712	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	SM00299
573	710	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PF00637
597	779	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
791	839	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006623	protein targeting to vacuole	Biological Process	IEA	GO_REF:0000002
GO:0006886	intracellular protein transport	Biological Process	IEA	GO_REF:0000120
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000120
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0008333	endosome to lysosome transport	Biological Process	IMP	PMID:25783203
GO:0009267	cellular response to starvation	Biological Process	IBA	GO_REF:0000033
GO:0016236	macroautophagy	Biological Process	IBA	GO_REF:0000033
GO:0034058	endosomal vesicle fusion	Biological Process	IEA	GO_REF:0000002
GO:0035542	regulation of SNARE complex assembly	Biological Process	NAS	PMID:24554770
GO:1902774	late endosome to lysosome transport	Biological Process	IMP	PMID:23167963
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000117
GO:0030123	AP-3 adaptor complex	Cellular Component	IDA	PMID:21411634
GO:0071439	clathrin complex	Cellular Component	IDA	PMID:21411634
GO:0005770	late endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000107
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0010008	endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0015630	microtubule cytoskeleton	Cellular Component	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030136	clathrin-coated vesicle	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0031901	early endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0031902	late endosome membrane	Cellular Component	IEA	GO_REF:0000120
GO:0030897	HOPS complex	Cellular Component	IBA	GO_REF:0000033
GO:1902501	lysosomal HOPS complex	Cellular Component	IDA	PMID:21802320
GO:0005773	vacuole	Cellular Component	IEA	GO_REF:0000104
GO:0005515	protein binding	Molecular Function	IPI	PMID:19109425
GO:0008017	microtubule binding	Molecular Function	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:24210660
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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