UBE2A

Details:

UniProt Entry: P49459
Gene: UBE2A
Class: Other E3 Components
Family: E2
Protein length: 152
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P49459
MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT
EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS
PANSQAAQLY QENKREYEKR VSAIVEQSWR DC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	152	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
1	149	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
4	150	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
7	141	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
8	143	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
77	92	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032446	protein modification by small protein conjugation	Biological Process	IEA	GO_REF:0000117
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0070979	protein K11-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0002181	cytoplasmic translation	Biological Process	IC	PMID:23636399
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:38297121
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	IDA	PMID:11953320
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006301	postreplication repair	Biological Process	NAS	PMID:1559696
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:11953320
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS	PMID:1559696
GO:0009411	response to UV	Biological Process	IGI	PMID:1717990
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:1901526	positive regulation of mitophagy	Biological Process	IDA	PMID:23685073
GO:0033503	HULC complex	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-8852130
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005770	late endosome	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:20061386
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:10908344
GO:0043130	ubiquitin binding	Molecular Function	TAS	Reactome:R-HSA-983152
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000003

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