>P41182 MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 2 | 129 | Homologous_superfamily | SKP1/BTB/POZ domain superfamily | IPR011333 | G3DSA:3.30.710.10 |
| 8 | 126 | Homologous_superfamily | SKP1/BTB/POZ domain superfamily | IPR011333 | SSF54695 |
| 22 | 128 | Domain | BTB/POZ domain | IPR000210 | PF00651 |
| 32 | 99 | Domain | BTB/POZ domain | IPR000210 | PS50097 |
| 32 | 129 | Domain | BTB/POZ domain | IPR000210 | SM00225 |
| 518 | 541 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 518 | 546 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 520 | 541 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| 527 | 583 | Homologous_superfamily | Zinc finger C2H2 superfamily | IPR036236 | SSF57667 |
| 546 | 573 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 546 | 568 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 548 | 568 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| 574 | 601 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 574 | 596 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 574 | 596 | Domain | Zinc finger C2H2-type | IPR013087 | PF00096 |
| 576 | 596 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| 583 | 639 | Homologous_superfamily | Zinc finger C2H2 superfamily | IPR036236 | SSF57667 |
| 602 | 624 | Domain | Zinc finger C2H2-type | IPR013087 | PF00096 |
| 602 | 629 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 602 | 624 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 604 | 624 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| 624 | 676 | Homologous_superfamily | Zinc finger C2H2 superfamily | IPR036236 | SSF57667 |
| 630 | 652 | Domain | Zinc finger C2H2-type | IPR013087 | PF00096 |
| 630 | 657 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 630 | 652 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 632 | 652 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| 658 | 681 | Domain | Zinc finger C2H2-type | IPR013087 | PS50157 |
| 658 | 681 | Domain | Zinc finger C2H2-type | IPR013087 | SM00355 |
| 660 | 681 | Domain | Zinc finger C2H2-type | IPR013087 | PS00028 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | Biological Process | IEA | GO_REF:0000108 |
| GO:0002376 | immune system process | Biological Process | IEA | GO_REF:0000043 |
| GO:0006954 | inflammatory response | Biological Process | IEA | GO_REF:0000043 |
| GO:0042981 | regulation of apoptotic process | Biological Process | IEA | GO_REF:0000117 |
| GO:0045580 | regulation of T cell differentiation | Biological Process | IEA | GO_REF:0000117 |
| GO:0045597 | positive regulation of cell differentiation | Biological Process | IEA | GO_REF:0000117 |
| GO:0051251 | positive regulation of lymphocyte activation | Biological Process | IEA | GO_REF:0000117 |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | Biological Process | IEA | GO_REF:0000117 |
| GO:0002317 | plasma cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0006366 | transcription by RNA polymerase II | Biological Process | IEA | GO_REF:0000107 |
| GO:0007160 | cell-matrix adhesion | Biological Process | IEA | GO_REF:0000107 |
| GO:0007266 | Rho protein signal transduction | Biological Process | IEA | GO_REF:0000107 |
| GO:0008283 | cell population proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0021859 | pyramidal neuron differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0032943 | mononuclear cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0042100 | B cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0045064 | T-helper 2 cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0048289 | isotype switching to IgE isotypes | Biological Process | IEA | GO_REF:0000107 |
| GO:0048870 | cell motility | Biological Process | IEA | GO_REF:0000107 |
| GO:0000902 | cell morphogenesis | Biological Process | IEA | GO_REF:0000107 |
| GO:0001953 | negative regulation of cell-matrix adhesion | Biological Process | IEA | GO_REF:0000107 |
| GO:0002467 | germinal center formation | Biological Process | IEA | GO_REF:0000107 |
| GO:0002829 | negative regulation of type 2 immune response | Biological Process | IEA | GO_REF:0000107 |
| GO:0006357 | regulation of transcription by RNA polymerase II | Biological Process | IEA | GO_REF:0000107 |
| GO:0007283 | spermatogenesis | Biological Process | IEA | GO_REF:0000107 |
| GO:0008104 | protein localization | Biological Process | IEA | GO_REF:0000107 |
| GO:0030036 | actin cytoskeleton organization | Biological Process | IEA | GO_REF:0000107 |
| GO:0030183 | B cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0030890 | positive regulation of B cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0031507 | heterochromatin formation | Biological Process | IEA | GO_REF:0000107 |
| GO:0032764 | negative regulation of mast cell cytokine production | Biological Process | IEA | GO_REF:0000107 |
| GO:0032945 | negative regulation of mononuclear cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0035024 | negative regulation of Rho protein signal transduction | Biological Process | IEA | GO_REF:0000107 |
| GO:0042092 | type 2 immune response | Biological Process | IEA | GO_REF:0000107 |
| GO:0042129 | regulation of T cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0043066 | negative regulation of apoptotic process | Biological Process | IEA | GO_REF:0000107 |
| GO:0043380 | regulation of memory T cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0045629 | negative regulation of T-helper 2 cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0045666 | positive regulation of neuron differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:0045746 | negative regulation of Notch signaling pathway | Biological Process | IEA | GO_REF:0000107 |
| GO:0048294 | negative regulation of isotype switching to IgE isotypes | Biological Process | IEA | GO_REF:0000107 |
| GO:0048821 | erythrocyte development | Biological Process | IEA | GO_REF:0000107 |
| GO:0050727 | regulation of inflammatory response | Biological Process | IEA | GO_REF:0000107 |
| GO:1900099 | negative regulation of plasma cell differentiation | Biological Process | IEA | GO_REF:0000107 |
| GO:2000147 | positive regulation of cell motility | Biological Process | IEA | GO_REF:0000107 |
| GO:2000773 | negative regulation of cellular senescence | Biological Process | IEA | GO_REF:0000107 |
| GO:0001817 | regulation of cytokine production | Biological Process | IBA | GO_REF:0000033 |
| GO:0002634 | regulation of germinal center formation | Biological Process | NAS | PMID:7795255 |
| GO:0002682 | regulation of immune system process | Biological Process | IBA | GO_REF:0000033 |
| GO:0002903 | negative regulation of B cell apoptotic process | Biological Process | NAS | PMID:15577913 |
| GO:0006974 | DNA damage response | Biological Process | IDA | PMID:15577913 |
| GO:0030308 | negative regulation of cell growth | Biological Process | IDA | PMID:10490843 |
| GO:0042127 | regulation of cell population proliferation | Biological Process | IBA | GO_REF:0000033 |
| GO:0043065 | positive regulation of apoptotic process | Biological Process | IDA | PMID:10490843 |
| GO:0045591 | positive regulation of regulatory T cell differentiation | Biological Process | IMP | PMID:20935202 |
| GO:0045595 | regulation of cell differentiation | Biological Process | IBA | GO_REF:0000033 |
| GO:0045892 | negative regulation of DNA-templated transcription | Biological Process | IMP | PMID:15577913 |
| GO:0050776 | regulation of immune response | Biological Process | NAS | PMID:16455075 |
| GO:1903464 | negative regulation of mitotic cell cycle DNA replication | Biological Process | NAS | PMID:10490843 |
| GO:0005634 | nucleus | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005657 | replication fork | Cellular Component | IDA | PMID:10490843 |
| GO:0005654 | nucleoplasm | Cellular Component | IBA | GO_REF:0000033 |
| GO:0005730 | nucleolus | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005794 | Golgi apparatus | Cellular Component | IDA | GO_REF:0000052 |
| GO:0042382 | paraspeckles | Cellular Component | IDA | PMID:16704730 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | Molecular Function | IEA | GO_REF:0000117 |
| GO:0003677 | DNA binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0003682 | chromatin binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:1990837 | sequence-specific double-stranded DNA binding | Molecular Function | IEA | GO_REF:0000117 |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | Molecular Function | IEA | GO_REF:0000107 |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Molecular Function | IBA | GO_REF:0000033 |
| GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding | Molecular Function | IEA | GO_REF:0000107 |
| GO:0001222 | transcription corepressor binding | Molecular Function | IPI | PMID:10898795 |
| GO:0003700 | DNA-binding transcription factor activity | Molecular Function | IMP | PMID:15577913 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:12590135 |
| GO:0031490 | chromatin DNA binding | Molecular Function | IEA | GO_REF:0000107 |
| GO:0042802 | identical protein binding | Molecular Function | IPI | PMID:25416956 |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | GO_REF:0000107 |
| GO:0140297 | DNA-binding transcription factor binding | Molecular Function | IPI | PMID:16704730 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL5287879 | ChEMBL | 6.58 | — | — | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C |
| E3 Binder | CHEMBL5205212 | ChEMBL | 8.66 | — | — | CC(=O)N[C@@H]1C[C@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5194697 | ChEMBL | 8.54 | — | — | CC(=O)N[C@H]1C[C@@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5273385 | ChEMBL | 7.2 | — | — | CC(C)CCC(=O)N1CCN2c3ncc(Cl)c(n3)Nc3cc4c(c(c3)OCCOC[C@H]2C1)N(C)C(=O)CC4 |
| E3 Binder | CHEMBL5277976 | ChEMBL | 7.34 | — | — | CC(C)CCC(=O)NCCCN1C(=O)CCc2cc3cc(c21)OCCOC[C@H]1COCCN1c1ncc(Cl)c(n1)N3 |
| E3 Binder | CHEMBL5089360 | ChEMBL | 7.27 | — | — | CC(Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncc(C2CC2)cn1 |
| E3 Binder | CHEMBL5083898 | ChEMBL | 6.85 | — | — | CC(Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncccn1 |
| E3 Binder | CHEMBL5089504 | ChEMBL | 6.7 | — | — | CC(Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncn(C)n1 |
| E3 Binder | CHEMBL5078380 | ChEMBL | 6.38 | — | — | CC(Nc1cc(=O)n(CC2CC2)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncccn1 |
| E3 Binder | CHEMBL5087272 | ChEMBL | 6.5 | — | — | CC(Nc1cc(=O)n(CC2CCC2)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncccn1 |
| E3 Binder | CHEMBL4459012 | ChEMBL | 6.19 | — | — | CC1CCCN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C1 |
| E3 Binder | CHEMBL4439574 | ChEMBL | 6.48 | — | — | CC1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)CCC1(F)F |
| E3 Binder | CHEMBL5186909 | ChEMBL | 6.0 | — | — | CC1Nc2c(c(=O)n(C)c3ccc(Nc4ccnc(Cl)c4C#N)cc23)OCC1(C)C |
| E3 Binder | CHEMBL5201812 | ChEMBL | 6.21 | — | — | CCC1CCOc2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc3n(C)c2=O)N1 |
| E3 Binder | CHEMBL5271784 | ChEMBL | 7.55 | — | — | CCN1CCN(c2cc(NC(=O)Cn3cc(-c4cc(C(N)=O)c(O)c(F)c4F)c4c(=O)n(C)cnc43)c(Cl)cn2)[C@@H](C)C1 |
| E3 Binder | CHEMBL5081404 | ChEMBL | 6.05 | — | — | CCNc1cc(=O)n(C)c2ccc(Nc3cc(C(=O)O)nc(Cl)c3C#N)cc12 |
| E3 Binder | CHEMBL4066000 | ChEMBL | 6.37 | — | — | CCOC(=O)CCNc1cc(Nc2ccc3[nH]c(=O)[nH]c3c2)c(Cl)cc1[N+](=O)[O-] |
| E3 Binder | CHEMBL5269254 | ChEMBL | 7.5 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)CNC(C)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)O |
| E3 Binder | CHEMBL4077626 | ChEMBL | 9.24 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C |
| E3 Binder | CHEMBL5195604 | ChEMBL | 9.22 | — | — | CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(C)=O)[C@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C |
| E3 Binder | CHEMBL4063061 | ChEMBL | 8.31 | — | — | CN1C(=O)CCc2cc3cc(c21)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4517433 | ChEMBL | 6.72 | — | — | CN1CCCCCOc2cc(cc3c2N(C)C(=O)CC3)Nc2cc1nc1c(C#N)cnn21 |
| E3 Binder | CHEMBL5184651 | ChEMBL | 8.05 | — | — | CN1CCN2c3nc(F)c(Cl)c(n3)Nc3cc4c(c(c3)OCCOC[C@H]2C1)N(C)C(=O)CC4 |
| E3 Binder | CHEMBL5079024 | ChEMBL | 6.26 | — | — | CNC(=O)C(C)Nc1cc(=O)[nH]c2ccc(Nc3ccnc(Cl)c3C#N)cc12 |
| E3 Binder | CHEMBL5089812 | ChEMBL | 6.1 | — | — | CNC(=O)C(C)Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12 |
| E3 Binder | CHEMBL5286830 | ChEMBL | 7.92 | — | — | CNC(=O)COc1cc2cc(Nc3nc(-n4nc(C)cc4C)ncc3Cl)ccc2n(C)c1=O |
| E3 Binder | CHEMBL4755229 | ChEMBL | 8.59 | — | — | CNC(=O)COc1cc2cc(Nc3nc(N4CCC(C(=O)N(C)C)CC4)ncc3Cl)cc(OC)c2n(C)c1=O |
| E3 Binder | CHEMBL4795171 | ChEMBL | 8.52 | — | — | CNC(=O)COc1cc2cc(Nc3nc(N4C[C@H](C)C[C@H](C)C4)ncc3Cl)cc(OC)c2n(C)c1=O |
| E3 Binder | CHEMBL4646073 | ChEMBL | 6.82 | — | — | CNC(=O)COc1cc2cc(Nc3nc(NCc4cccc(S(=O)(=O)F)c4)ncc3Cl)cc(OC)c2n(C)c1=O |
| E3 Binder | CHEMBL4644523 | ChEMBL | 6.43 | — | — | CNC(=O)COc1cc2cc(Nc3nc(NCc4cccc(S(C)(=O)=O)c4)ncc3Cl)cc(OC)c2n(C)c1=O |
| E3 Binder | CHEMBL5080836 | ChEMBL | 6.6 | VHZ | — | CNC(=O)[C@@H](C)Nc1cc(=O)[nH]c2ccc(Nc3ccnc(Cl)c3C#N)cc12 |
| E3 Binder | CHEMBL4573672 | ChEMBL | 6.7 | — | — | COCC1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)CCC1(F)F |
| E3 Binder | CHEMBL5276120 | ChEMBL | 7.37 | — | — | COc1c(O)c(C(N)=O)cc(-c2cn(CC(=O)Nc3cc(N4CCN(C)C[C@@H]4C)nc(F)c3Cl)c3ncn(C)c(=O)c23)c1F |
| E3 Binder | CHEMBL5285053 | ChEMBL | 6.88 | — | — | COc1c(O)c(C(N)=O)cc(-c2cn(CC(=O)Nc3cc(N4CCN(C)C[C@@H]4C)ncc3Cl)c3ncn(C)c(=O)c23)c1F |
| E3 Binder | CHEMBL4456817 | ChEMBL | 6.28 | — | — | COc1cc(Nc2nc(N3C[C@@H](C)N[C@@H](C)C3)ncc2F)ccc1NC(=O)c1ccc(-c2ccoc2)s1 |
| E3 Binder | CHEMBL4538610 | ChEMBL | 6.44 | — | — | COc1cc(Nc2nc(N3C[C@@H](C)N[C@@H](C)C3)ncc2F)ccc1NC(=O)c1ccc(C2=CCCC2)s1 |
| E3 Binder | CHEMBL4527835 | ChEMBL | 6.01 | — | — | COc1ccc(Nc2nc(N3CCNCC3)ncc2F)cc1Cl |
| E3 Binder | CHEMBL4446667 | ChEMBL | 6.11 | — | — | COc1ccc(Nc2nc(N3C[C@@H](C)N[C@@H](C)C3)ncc2F)cc1Cl |
| E3 Binder | CHEMBL4445208 | ChEMBL | 6.05 | — | — | COc1ccc(Nc2nc(NC3CCN(C)CC3)ncc2F)cc1Cl |
| E3 Binder | CHEMBL4530646 | ChEMBL | 6.07 | — | — | COc1ccc(Nc2nc(NCCCO)ncc2F)cc1Cl |
| E3 Binder | CHEMBL4073463 | ChEMBL | 7.96 | — | — | COc1cccc(CN2C(=O)CCc3cc4cc(c32)OC/C=C/CO[C@H]2C[C@@H](CO)N(C2)c2cc(n3ncc(C#N)c3n2)N4)c1 |
| E3 Binder | CHEMBL4092565 | ChEMBL | 7.92 | — | — | COc1cccc(CN2C(=O)CCc3cc4cc(c32)OC/C=C/CO[C@H]2C[C@@H](CO)N(C2)c2cc(n3ncc(Cl)c3n2)N4)c1 |
| E3 Binder | CHEMBL5284699 | ChEMBL | 7.06 | — | — | COc1nc2c(c(-c3cc(C(N)=O)c(O)c(F)c3F)cn2CC(=O)Nc2cc(N3CCN(C)C[C@@H]3C)nc(F)c2Cl)c(=O)n1C |
| E3 Binder | CHEMBL4483413 | ChEMBL | 6.17 | — | — | CSc1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 |
| E3 Binder | CHEMBL5084306 | ChEMBL | 7.09 | VJ5 | — | C[C@@H](Nc1cc(=O)n(C)c2ccc(Nc3ccnc(Cl)c3C#N)cc12)c1ncccn1 |
| E3 Binder | CHEMBL4448503 | ChEMBL | 7.6 | — | — | C[C@@H]1CCCCN(C)c2cc(n3ncc(C#N)c3n2)Nc2cc3c(c(c2)O1)N(C)C(=O)CC3 |
| E3 Binder | CHEMBL5172688 | ChEMBL | 7.61 | — | — | C[C@@H]1CCCN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL4475438 | ChEMBL | 6.03 | — | — | C[C@@H]1CN(c2cc(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)c(Cl)cn2)C[C@H](C)O1 |
| E3 Binder | CHEMBL4445645 | ChEMBL | 7.27 | NQZ | — | C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)C1(F)F |
| E3 Binder | CHEMBL4458261 | ChEMBL | 6.72 | — | — | C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)N1C |
| E3 Binder | CHEMBL4476234 | ChEMBL | 6.82 | NQW | — | C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@H](C)O1 |
| E3 Binder | CHEMBL5288047 | ChEMBL | 7.92 | — | — | C[C@@H]1COCCN1c1cc(NC(=O)Cn2cc(-c3cc(Cl)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5180823 | ChEMBL | 8.0 | — | — | C[C@@H]1C[C@@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL4547183 | ChEMBL | 6.12 | — | — | C[C@@H]1C[C@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C1 |
| E3 Binder | CHEMBL5205838 | ChEMBL | 8.44 | — | — | C[C@@H]1C[C@H](N(C)C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5196650 | ChEMBL | 8.54 | — | — | C[C@@H]1C[C@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5172641 | ChEMBL | 8.2 | — | — | C[C@H]1CCCN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5178675 | ChEMBL | 6.89 | 9IE | — | C[C@H]1CCOc2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc3n(C)c2=O)N1 |
| E3 Binder | CHEMBL5267621 | ChEMBL | 7.07 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(Cl)c3F)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5286263 | ChEMBL | 6.33 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(Cl)c3F)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5286712 | ChEMBL | 6.94 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n(C)c(C(F)(F)F)nc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5291358 | ChEMBL | 7.96 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5291478 | ChEMBL | 7.5 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5279363 | ChEMBL | 8.3 | YN7 | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n4c(nc32)CCC4)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5271863 | ChEMBL | 7.58 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n4c(nc32)CCCC4)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5272054 | ChEMBL | 7.33 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n4c(nc32)CCCCC4)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5270031 | ChEMBL | 9.0 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c4c3OCO4)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5282647 | ChEMBL | 9.3 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c4c3OCO4)c3c(=O)n4c(nc32)CCC4)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5268066 | ChEMBL | 6.9 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)cc3F)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5275407 | ChEMBL | 8.05 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(Cl)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5288796 | ChEMBL | 6.9 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(Cl)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5285804 | ChEMBL | 8.52 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(F)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5287446 | ChEMBL | 7.5 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(F)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5284819 | ChEMBL | 6.72 | — | — | C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(F)c(O)c(C(N)=O)c3F)c3c(=O)n(C)cnc32)c(Cl)c(F)n1 |
| E3 Binder | CHEMBL5267171 | ChEMBL | 7.0 | — | — | C[C@H]1CN(C)C[C@H](C)N1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5279299 | ChEMBL | 7.62 | — | — | C[C@H]1CN(C2COC2)CCN1c1cc(NC(=O)Cn2cc(-c3cc(C(N)=O)c(O)c(F)c3F)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5199127 | ChEMBL | 7.03 | 9FW | — | C[C@H]1COC(=O)c2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc3n(C)c2=O)N1 |
| E3 Binder | CHEMBL5279982 | ChEMBL | 7.96 | YJS | — | C[C@H]1COCCN1c1cc(NC(=O)Cn2cc(-c3cc(Cl)c(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5269124 | ChEMBL | 7.68 | — | — | C[C@H]1COCCN1c1cc(NC(=O)Cn2cc(-c3ccc(O)c(C(N)=O)c3)c3c(=O)n(C)cnc32)c(Cl)cn1 |
| E3 Binder | CHEMBL5193571 | ChEMBL | 8.48 | — | — | C[C@H]1C[C@@H](N(C)C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5205388 | ChEMBL | 9.15 | EBL | — | C[C@H]1C[C@@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5200057 | ChEMBL | 7.46 | — | — | C[C@H]1C[C@@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C1 |
| E3 Binder | CHEMBL5187360 | ChEMBL | 6.32 | — | — | C[C@H]1C[C@H](C)Oc2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc3n(C)c2=O)N1 |
| E3 Binder | CHEMBL5171631 | ChEMBL | 8.22 | — | — | C[C@H]1C[C@H](O)CN(c2ncc(Cl)c(Nc3ccc4c(c3)c3c(c(=O)n4C)OCC(F)(F)[C@H](C4CC4)N3)n2)C1 |
| E3 Binder | CHEMBL5287071 | ChEMBL | 7.66 | — | — | Cc1cc(-c2cn(CC(=O)Nc3ccncc3Cl)c3ncn(C)c(=O)c23)cc(C#N)c1O |
| E3 Binder | CHEMBL4467613 | ChEMBL | 6.1 | — | — | Cc1cc(C)n(-c2cc(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)c(Cl)cn2)n1 |
| E3 Binder | CHEMBL4451702 | ChEMBL | 6.58 | NQT | — | Cc1cc(C)n(-c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)n1 |
| E3 Binder | CHEMBL4083842 | ChEMBL | 7.54 | — | — | Cc1ccc(CN2C(=O)CCc3cc4cc(c32)OC/C=C/CO[C@H]2C[C@@H](CO)N(C2)c2cc(n3ncc(Cl)c3n2)N4)cc1 |
| E3 Binder | CHEMBL4100303 | ChEMBL | 7.89 | — | — | Cc1ccccc1CN1C(=O)CCc2cc3cc(c21)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4583696 | ChEMBL | 6.4 | — | — | Cc1ccn(-c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)n1 |
| E3 Binder | CHEMBL4450499 | ChEMBL | 6.37 | — | — | Cc1ccnn1-c1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 |
| E3 Binder | CHEMBL5073907 | ChEMBL | 7.14 | — | — | Cc1cnc(C(C)Nc2cc(=O)n(C)c3ccc(Nc4ccnc(Cl)c4C#N)cc23)nc1 |
| E3 Binder | CHEMBL5285971 | ChEMBL | 7.96 | — | — | Cc1nc2c(c(-c3cc(C(N)=O)c(O)c(F)c3F)cn2CC(=O)Nc2cc(N3CCN(C)C[C@@H]3C)nc(F)c2Cl)c(=O)n1C |
| E3 Binder | CHEMBL5290428 | ChEMBL | 7.36 | — | — | Cc1nc2c(c(-c3cc(C(N)=O)c(O)c(F)c3F)cn2CC(=O)Nc2cc(N3CCN(C)C[C@@H]3C)ncc2Cl)c(=O)n1C |
| E3 Binder | CHEMBL5279858 | ChEMBL | 6.92 | — | — | Cc1nc2c(c(-c3cc(C(N)=O)c(O)c4c3OCCO4)cn2CC(=O)Nc2cc(N3CCN(C)C[C@@H]3C)nc(F)c2Cl)c(=O)n1C |
| E3 Binder | CHEMBL5283745 | ChEMBL | 9.0 | — | — | Cc1nc2c(c(-c3cc(C(N)=O)c(O)c4c3OCO4)cn2CC(=O)Nc2cc(N3CCN(C)C[C@@H]3C)nc(F)c2Cl)c(=O)n1C |
| E3 Binder | CHEMBL5178494 | ChEMBL | 8.0 | TEQ | — | Cc1ncccc1[C@H]1C[C@@H](c2cccc3nc(N)ccc23)Nc2c(F)cnn21 |
| E3 Binder | CHEMBL1984039 | ChEMBL | 6.32 | — | — | Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)[nH]c12 |
| E3 Binder | CHEMBL5077701 | ChEMBL | 6.06 | — | — | Cc1nnc(C(C)Nc2cc(=O)n(C)c3ccc(Nc4ccnc(Cl)c4C#N)cc23)o1 |
| E3 Binder | CHEMBL5203649 | ChEMBL | 7.11 | — | — | Cn1c(=O)c2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc31)NC(C1CC1)CCO2 |
| E3 Binder | CHEMBL5184251 | ChEMBL | 8.41 | 9IH | — | Cn1c(=O)c2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5173162 | ChEMBL | 7.41 | 9GR | — | Cn1c(=O)c2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc31)N[C@@H](C1CC1)CCO2 |
| E3 Binder | CHEMBL5171937 | ChEMBL | 6.31 | — | — | Cn1c(=O)c2c(c3cc(Nc4ccnc(Cl)c4C#N)ccc31)N[C@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5204505 | ChEMBL | 8.82 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC(F)(F)[C@@H](CO)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5208698 | ChEMBL | 8.46 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC(F)(F)[C@@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5203177 | ChEMBL | 8.39 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC(F)(F)[C@H](CO)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5174171 | ChEMBL | 8.34 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC(F)(F)[C@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5181921 | ChEMBL | 8.52 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC[C@@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5171519 | ChEMBL | 8.6 | — | — | Cn1c(=O)c2c(c3cc(Nc4nc(N5CCC[C@H](O)C5)ncc4Cl)ccc31)N[C@@H](C1CC1)C(F)(F)CO2 |
| E3 Binder | CHEMBL5081944 | ChEMBL | 7.58 | VGW | — | Cn1c(=O)cc(NC(C)(C)c2ncc(C3CC3)cn2)c2cc(Nc3ccnc(Cl)c3C#N)ccc21 |
| E3 Binder | CHEMBL5081226 | ChEMBL | 7.34 | VJ2 | — | Cn1c(=O)cc(NC(C)(C)c2ncccn2)c2cc(Nc3ccnc(Cl)c3C#N)ccc21 |
| E3 Binder | CHEMBL5075643 | ChEMBL | 6.46 | — | — | Cn1c(=O)cc(NCC2CC2)c2cc(Nc3cc(C(=O)O)nc(Cl)c3C#N)ccc21 |
| E3 Binder | CHEMBL5081380 | ChEMBL | 6.06 | — | — | Cn1c(=O)cc(NCCF)c2cc(Nc3cc(C(=O)O)nc(Cl)c3C#N)ccc21 |
| E3 Binder | CHEMBL4572689 | ChEMBL | 6.07 | NQQ | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3ccnc(Cl)c3C#N)ccc21 |
| E3 Binder | CHEMBL4451202 | ChEMBL | 6.0 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3ccncc3Cl)ccc21 |
| E3 Binder | CHEMBL4548894 | ChEMBL | 6.15 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(-n4cccn4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4524719 | ChEMBL | 6.64 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4C5CCC4CC(F)(F)C5)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4574515 | ChEMBL | 7.01 | NR5 | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CC(C)(C)OC(C)(C)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4525209 | ChEMBL | 6.15 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CC5CCC(C4)C5(F)F)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4457011 | ChEMBL | 6.02 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(C(F)(F)F)CC4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4559074 | ChEMBL | 7.1 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(F)(F)C(CO)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL5187061 | ChEMBL | 6.62 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(F)(F)C(O)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4587209 | ChEMBL | 6.51 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(F)(F)CC4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4466680 | ChEMBL | 6.41 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(C#N)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4482923 | ChEMBL | 6.4 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(C(F)(F)F)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4465387 | ChEMBL | 6.89 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(CO)C4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4469177 | ChEMBL | 6.0 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCCC4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4463841 | ChEMBL | 6.57 | — | — | Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCOCC4)ncc3Cl)ccc21 |
| E3 Binder | CHEMBL4475529 | ChEMBL | 6.32 | — | — | Cn1ccnc1-c1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 |
| E3 Binder | CHEMBL5269780 | ChEMBL | 7.89 | — | — | Cn1cnc2c(c(-c3cc(Cl)c(O)c(C(N)=O)c3)cn2CC(=O)Nc2cc(N3CCOCC3)ncc2Cl)c1=O |
| E3 Binder | CHEMBL5267067 | ChEMBL | 7.27 | YNA | — | Cn1cnc2c(c(-c3ccc(O)c(C#N)c3)cn2CC(=O)Nc2ccncc2Cl)c1=O |
| E3 Binder | CHEMBL5271042 | ChEMBL | 7.42 | — | — | Cn1cnc2c(c(-c3ccc(O)c(C(N)=O)c3)cn2CC(=O)Nc2cc(N3CCOCC3)ncc2Cl)c1=O |
| E3 Binder | CHEMBL5271895 | ChEMBL | 6.92 | — | — | Cn1cnc2c(c(-c3ccc(O)c(C(N)=O)c3)cn2CC(=O)Nc2ccncc2Cl)c1=O |
| E3 Binder | CHEMBL4061037 | ChEMBL | 6.23 | — | — | N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@@H]3CO)nc12 |
| E3 Binder | CHEMBL4061857 | ChEMBL | 6.46 | 8HN | — | N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@H]3CC(=O)O)nc12 |
| E3 Binder | CHEMBL4077836 | ChEMBL | 6.43 | — | — | N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@H]3CO)nc12 |
| E3 Binder | CHEMBL4072708 | ChEMBL | 6.68 | — | — | N#Cc1cnn2c3cc(nc12)N1CCC[C@@H]1CC(=O)NCCOc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4093431 | ChEMBL | 7.82 | — | — | N#Cc1cnn2c3cc(nc12)N1CC[C@@H](C1)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4085689 | ChEMBL | 7.62 | — | — | N#Cc1cnn2c3cc(nc12)N1CC[C@@H](C1)OCCCCOc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4066850 | ChEMBL | 8.77 | — | — | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CC(=O)O)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4094351 | ChEMBL | 8.54 | 8GQ | — | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4072699 | ChEMBL | 6.41 | — | — | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OC/C=C/COc1cccc(c1)N3 |
| E3 Binder | CHEMBL4093418 | ChEMBL | 8.62 | — | — | N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OCCCCOc1cc(cc2c1NC(=O)CC2)N3 |
| E3 Binder | CHEMBL4085850 | ChEMBL | 6.89 | 80L | — | O=C(O)CCNc1cc(Nc2ccc3[nH]c(=O)[nH]c3c2)c(Cl)cc1[N+](=O)[O-] |
| E3 Binder | CHEMBL4102754 | ChEMBL | 7.8 | — | — | O=C(O)C[C@@H]1C[C@H]2CN1c1cc(n3ncc(Cl)c3n1)Nc1cc3c(c(c1)OC/C=C/CO2)N(CC1CC(F)(F)C1)C(=O)CC3 |
| E3 Binder | CHEMBL4075278 | ChEMBL | 7.0 | — | — | O=C1CCc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc2N1 |
| E3 Binder | CHEMBL4090962 | ChEMBL | 8.82 | — | — | O=C1CCc2cc3cc(c2N1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4101172 | ChEMBL | 8.48 | — | — | O=C1CCc2cc3cc(c2N1)OCCCCO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4083173 | ChEMBL | 7.26 | — | — | O=C1CCc2cc3cc(c2N1)OCCCCO[C@H]1C[C@@H](CO)N(C1)c1cc(n2nccc2n1)N3 |
| E3 Binder | CHEMBL4096773 | ChEMBL | 8.3 | — | — | O=C1CCc2cc3cc(c2N1CC1CC(F)(F)C1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4078747 | ChEMBL | 7.44 | — | — | O=C1CCc2cc3cc(c2N1CC1CC1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4084806 | ChEMBL | 9.06 | — | — | O=C1CCc2cc3cc(c2N1CCCN1CCOCC1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4064865 | ChEMBL | 7.96 | — | — | O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4062105 | ChEMBL | 8.0 | — | — | O=C1CCc2cc3cc(c2N1Cc1ccncc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 |
| E3 Binder | CHEMBL4076344 | ChEMBL | 6.89 | — | — | O=C1Cc2cc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)ccc2N1 |
| E3 Binder | CHEMBL4640734 | ChEMBL | 6.6 | — | — | O=C1Cc2cc(Nc3nc(NCc4cccc(S(=O)(=O)F)c4)ncc3Cl)ccc2N1 |
| E3 Binder | CHEMBL4077392 | ChEMBL | 7.11 | 7Z6 | — | O=C1Cc2cc(Nc3nc(NCc4cccnc4)ncc3Cl)ccc2N1 |
| E3 Binder | CHEMBL4076619 | ChEMBL | 6.89 | — | — | O=c1[nH]c2ccc(Nc3cc(NC4CCOCC4)c([N+](=O)[O-])cc3Cl)cc2[nH]1 |
| E3 Binder | CHEMBL4093597 | ChEMBL | 6.62 | — | — | O=c1[nH]c2ccc(Nc3cc(NCCCO)c([N+](=O)[O-])cc3Cl)cc2[nH]1 |
| E3 Binder | CHEMBL4103775 | ChEMBL | 6.82 | — | — | O=c1[nH]c2ccc(Nc3cc(NCc4cccnc4)c([N+](=O)[O-])cc3Cl)cc2[nH]1 |
| E3 Binder | CHEMBL4069588 | ChEMBL | 6.66 | — | — | O=c1[nH]c2ccc(Nc3cc(OC4CCOCC4)c([N+](=O)[O-])cc3Cl)cc2[nH]1 |