CCNF

Details:

UniProt Entry: P41002
Gene: CCNF
Class: Other E3 Components
Family: Receptor
Protein length: 786
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P41002
MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS
QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD
EARAEVNGLK ASRFFSLAER LNVGAAPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR
THKASILHCL GRVLSLFEDE EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC
LHSFRKLRDY AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS
VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM
VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA LEGKIRVPTV VDYKEVLLTL
VPVELRTQHL CSFLCELSLL HTSLSAYAPA RLAAAALLLA RLTHGQTQPW TTQLWDLTGF
SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL
GVTQDSPDPP TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC QESSDEEACP
EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS GYSSVSTASP TSSVDGGLGA
LPQPTSVLSL DSDSHTQPCH HQARKSCLQC RPPSPPESSV PQQQVKRINL CIHSEEEDMN
LGLVRL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
29	76	Domain	F-box domain	IPR001810	PS50181
32	114	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
32	68	Domain	F-box domain	IPR001810	PF00646
35	75	Domain	F-box domain	IPR001810	SM00256
86	284	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
264	497	Family	Cyclin	IPR039361	PTHR10177
289	405	Domain	Cyclin, N-terminal	IPR006671	PF00134
290	404	Homologous_superfamily	Cyclin-like superfamily	IPR036915	SSF47954
309	398	Domain	Cyclin-like domain	IPR013763	cd00043
310	341	Domain	Cyclin, N-terminal	IPR006671	PS00292
315	399	Domain	Cyclin-like domain	IPR013763	SM00385
407	530	Homologous_superfamily	Cyclin-like superfamily	IPR036915	SSF47954
408	531	Domain	Cyclin, C-terminal domain	IPR004367	SM01332
409	527	Domain	Cyclin, C-terminal domain	IPR004367	PF02984
416	494	Domain	Cyclin-like domain	IPR013763	SM00385

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0000320	re-entry into mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0001890	placenta development	Biological Process	IEA	GO_REF:0000107
GO:0010826	negative regulation of centrosome duplication	Biological Process	IEA	GO_REF:0000120
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:20596027
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:20596027
GO:0051726	regulation of cell cycle	Biological Process	IDA	PMID:25557911
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005815	microtubule organizing center	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005814	centriole	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Cellular Component	IBA	GO_REF:0000033
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:20596027
GO:0005515	protein binding	Molecular Function	IPI	PMID:20596027
GO:0010997	anaphase-promoting complex binding	Molecular Function	IDA	PMID:25557911
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	Molecular Function	IBA	GO_REF:0000033

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