VHL

Start	End	Type	Name	InterPro	Source
60	207	Homologous_superfamily	VHL superfamily	IPR036208	SSF49468
63	143	Domain	von Hippel-Lindau disease tumour suppressor, beta domain	IPR024053	PF01847
63	152	Homologous_superfamily	von Hippel-Lindau disease tumour suppressor, beta domain superfamily	IPR037140	G3DSA:2.60.40.780
64	203	Domain	von Hippel-Lindau disease tumour suppressor, beta/alpha domain	IPR022772	cd05468
153	204	Homologous_superfamily	von Hippel-Lindau disease tumour suppressor, alpha domain superfamily	IPR037139	G3DSA:1.10.750.10
156	204	Domain	von Hippel-Lindau disease tumour suppressor, alpha domain	IPR024048	PF17211

GO term	Name	Ontology	Evidence	Reference
GO:0001666	response to hypoxia	Biological Process	IEA	GO_REF:0000117
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0010558	negative regulation of macromolecule biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:11641274
GO:0000902	cell morphogenesis	Biological Process	NAS	PMID:12169691
GO:0006355	regulation of DNA-templated transcription	Biological Process	IMP	PMID:15824735
GO:0006508	proteolysis	Biological Process	TAS	PMID:10353251
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:23338840
GO:0009968	negative regulation of signal transduction	Biological Process	EXP	PMID:23338840
GO:0010507	negative regulation of autophagy	Biological Process	IDA	PMID:30902965
GO:0010629	negative regulation of gene expression	Biological Process	IMP	PMID:23338840
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Biological Process	IDA	PMID:7660122
GO:0043066	negative regulation of apoptotic process	Biological Process	NAS	PMID:12169691
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34290272
GO:0045597	positive regulation of cell differentiation	Biological Process	NAS	PMID:12169691
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IMP	PMID:17973242
GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	Biological Process	IMP	PMID:23338840
GO:0050821	protein stabilization	Biological Process	NAS	PMID:12169691
GO:0071456	cellular response to hypoxia	Biological Process	TAS	Reactome:R-HSA-1234176
GO:1900037	regulation of cellular response to hypoxia	Biological Process	EXP	PMID:10205047
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:34290272
GO:1990000	amyloid fibril formation	Biological Process	EXP	PMID:34431623
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005929	cilium	Cellular Component	IDA	GO_REF:0000052
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0005739	mitochondrion	Cellular Component	NAS	PMID:12169691
GO:0005829	cytosol	Cellular Component	TAS	PMID:7604013
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0003711	transcription elongation factor activity	Molecular Function	IDA	PMID:7660122
GO:0003714	transcription corepressor activity	Molecular Function	IEP	PMID:11641274
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	Reactome:R-HSA-1234163
GO:0005515	protein binding	Molecular Function	IPI	PMID:11292862
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:11641274
GO:0060090	molecular adaptor activity	Molecular Function	EXP	PMID:10205047
GO:0120283	protein serine/threonine kinase binding	Molecular Function	IPI	PMID:23785518
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IPI	PMID:11641274
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:24899725

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Handle	—	PROTACDB3	6.0*	—	—	C#Cc1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(C)=O)C(C)(C)C)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	C#Cc1ccc([C@H](CC(=O)NC)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](c2cc(C)no2)C(C)C)cc1
E3 Binder	CHEMBL4594350	ChEMBL	6.6	—	—	C=C(F)C(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(Cl)c24)C3)C[C@@H]1CC#N
E3 Binder	CHEMBL5289777	ChEMBL	6.6	—	—	C=C(F)C(=O)N1CCN(c2nc(O[C@@H]3CCCN3CCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)nc3c2CCN(c2cccc4cccc(Cl)c24)C3)C[C@H]1CC#N
E3 Binder	CHEMBL5185820	ChEMBL	7.68	—	—	C=CC(=O)N1CCC[C@H](n2c(Nc3ccccc3)nc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)C1
E3 Binder	CHEMBL5202214	ChEMBL	8.0	—	—	C=CC(=O)N1CC[C@H](n2c(Nc3ccccc3)nc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)C1
E3 Binder	CHEMBL3353410	ChEMBL	9.0	YY3	—	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C
E3 Binder	CHEMBL4228950	ChEMBL	7.01	9BN	—	CC(=O)C1(C(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1
E3 Binder	CHEMBL3344084	ChEMBL	6.42	—	—	CC(=O)N1CCCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL3344083	ChEMBL	6.15	—	—	CC(=O)N1CCC[C@H]1C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL5176485	ChEMBL	6.4	—	—	CC(=O)N1c2ccc(-c3ccc(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C
E3 Binder	CHEMBL4228624	ChEMBL	6.86	9BK	—	CC(=O)NC1(C(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1
E3 Binder	CHEMBL4227864	ChEMBL	6.36	9B5	—	CC(=O)N[C@@H](C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL3344086	ChEMBL	6.03	—	—	CC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL4228750	ChEMBL	6.12	DV5	—	CC(=O)N[C@@H](C)C(=S)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL3344087	ChEMBL	6.23	3JH	—	CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Handle	CHEMBL3344088	PROTACDB3, ChEMBL	6.54	3JO	—	CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Handle	CHEMBL3344081	PROTACDB3, ChEMBL	6.97	3JF	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL3344082	ChEMBL	6.08	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)c1ccccc1
E3 Handle	CHEMBL4565531	PROTACDB3, ChEMBL	6.79	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C#N)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C(C)(C)C)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C(C)C)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C2CC2)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(Cl)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	EXE	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)[C@@H](F)[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	EXH	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)[C@H](F)[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL5178277	ChEMBL	8.29	—	—	CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCOc5cc(-c6scnc6C)ccc5CNC(=O)[C@H]5C[C@H](O)CN5C(=O)[C@@H](NC(=O)C5(F)CC5)C(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O
E3 Binder	CHEMBL4228328	ChEMBL	6.46	—	—	CCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL5290643	ChEMBL	7.38	—	—	CCCNNC(=O)c1ccc(-c2ccc(NC(=O)CCCCCCC(=O)NC(C(=O)N3C[C@@H](O)C[C@@H]3C(=O)N[C@H](C)c3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)cc1
E3 Binder	CHEMBL3774575	ChEMBL	8.1	4C1	—	CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL3775853	ChEMBL	7.37	—	—	CCCOc1cccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1
E3 Binder	CHEMBL5081978	ChEMBL	6.99	—	—	CC[C@@H](C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C)[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21
E3 Binder	CHEMBL5089280	ChEMBL	7.35	—	—	CC[C@@H](C(=O)OCCOCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21
E3 Binder	CHEMBL5089544	ChEMBL	6.9	—	—	CC[C@@H](C(=O)OCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C)[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21
E3 Binder	CHEMBL4081711	ChEMBL	7.8	8CG	—	CC[C@@H]1[C@H](F)C(=O)N[C@@H]1COc1nccc2cc(C(N)=O)c(OC)cc12
E3 Handle	CHEMBL5269644	PROTACDB3, ChEMBL	6.75	—	—	CNC(=O)C[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)C1(F)CC1)C(C)(C)C)c1ccc(-c2scnc2C)cc1
E3 Handle	CHEMBL5277721	PROTACDB3, ChEMBL	7.54	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)C1(C#N)CC1)C(C)(C)C)c1ccc(-c2scnc2C)cc1
E3 Handle	CHEMBL5283593	PROTACDB3, ChEMBL	6.72	QF7	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)C1(F)CC1)C(C)(C)C)c1ccc(-c2scnc2C)cc1
E3 Handle	CHEMBL5285978	PROTACDB3, ChEMBL	6.89	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(C)=O)C(C)(C)C)c1ccc(-c2scnc2C)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(C)=O)C(C)C)c1ccccc1
E3 Handle	CHEMBL4449823	PROTACDB3, ChEMBL	7.57	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Br)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(C#N)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Cl)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(F)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1
E3 Handle	CHEMBL5274336	PROTACDB3, ChEMBL	7.11	—	—	CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)C1(F)CC1)C(C)(C)C)c1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL5271909	ChEMBL	6.5	—	—	Cc1ccc(NC(=O)Cn2cc(-c3ccc4c(NC(=O)c5ccc(N)cc5)nn(C(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)c4c3)cn2)cc1C(F)(F)F
E3 Binder	CHEMBL3683782	ChEMBL	6.75	—	—	Cc1ccnc(-n2[nH]cc(-c3ccc(C#N)nc3)c2=O)c1
E3 Binder	CHEMBL5175569	ChEMBL	6.67	—	—	Cc1ccsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2NC(=O)/C=C/CN(C)C)C(C)(C)C)cc1
E3 Handle	—	PROTACDB3	6.0*	—	—	Cc1nc(C)c(-c2ccc(-c3c[nH]c([C@@H]4C[C@@H](O)CN4C(=O)[C@@H](N)C(C)(C)C)n3)cc2)s1
E3 Handle	—	PROTACDB3	6.0*	—	—	Cc1nc(C)c(-c2ccc([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](N)C(C)(C)C)cc2)s1
E3 Binder	CHEMBL3683781	ChEMBL	6.12	—	—	Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O
E3 Handle	—	PROTACDB3	6.0*	—	—	Cc1ncsc1-c1ccc(-c2c[nH]c([C@@H]3C[C@@H](O)CN3C(=O)[C@@H](N)C(C)(C)C)n2)cc1
E3 Binder	CHEMBL4229225	ChEMBL	6.11	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(C)(C)F)C(C)(C)C)cc1
E3 Binder	CHEMBL4225199	ChEMBL	6.7	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(Cl)(Cl)Cl)C(C)(C)C)cc1
E3 Binder	CHEMBL4228963	ChEMBL	6.57	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C)cc1
E3 Handle	CHEMBL4225537	PROTACDB3, ChEMBL	7.28	6Z3	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1
E3 Handle	CHEMBL4225470	PROTACDB3, ChEMBL	7.8	4YY	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4228692	ChEMBL	6.43	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)[C@@H](C)O)cc1
E3 Binder	CHEMBL4224868	ChEMBL	6.3	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CC(=O)C2)C(C)(C)C)cc1
E3 Binder	CHEMBL4227893	ChEMBL	6.88	9BW	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4229211	ChEMBL	6.68	9BH	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CCC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4225714	ChEMBL	6.64	9B8	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2COC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4225145	ChEMBL	6.35	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CC(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL5087145	ChEMBL	6.92	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCNC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5082521	ChEMBL	6.87	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5087530	ChEMBL	6.77	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCNC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5086047	ChEMBL	6.7	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5094871	ChEMBL	6.77	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5086897	ChEMBL	6.7	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL4793272	ChEMBL	6.86	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCNC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5081396	ChEMBL	6.84	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL4225856	ChEMBL	6.98	9BT	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CO)C(C)(C)C)cc1
E3 Binder	CHEMBL4779321	ChEMBL	6.51	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCNC(=O)COc2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5)CC4)ncnc3c2)C(C)(C)C)cc1
E3 Binder	CHEMBL5274307	ChEMBL	7.96	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL4205154	ChEMBL	8.85	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)OC(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL4783485	ChEMBL	6.35	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL4782620	ChEMBL	6.1	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](OC(=O)Cc2ccccc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5269969	ChEMBL	6.27	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C(C)C)N2Cc3ccccc3C2=O)c(OCCOCCOCCOCCCCCCCl)c1
E3 Handle	—	PROTACDB3	6.0*	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C(C)C)N2Cc3ccccc3C2=O)cc1
E3 Binder	CHEMBL3260851	ChEMBL	6.17	TG0	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)c2cccc(N)c2C)cc1
E3 Binder	CHEMBL5196036	ChEMBL	6.54	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL5266174	ChEMBL	9.15	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)COCC(C)(COCCOCCOCCNC(=O)C[C@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)COCCOCCOCCNC(=O)C[C@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1
E3 Binder	CHEMBL5282858	ChEMBL	8.96	—	—	Cc1ncsc1-c1ccc([C@@H](C)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CCCCOc2ccc(CCNC(=O)c3ccc(C(=O)c4c(-c5ccc(O)cc5)sc5cc(O)ccc45)cc3)cc2)C(C)(C)C)cc1
E3 Binder	CHEMBL5197462	ChEMBL	7.2	—	—	Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccccc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1
E3 Binder	CHEMBL5177351	ChEMBL	7.89	—	—	Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1
E3 Binder	CHEMBL5191950	ChEMBL	7.2	—	—	Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)N(C(=O)[C@@H](NC(=O)CCCCCC(=O)N3CCN(CC[C@H](CSc4ccccc4)Nc4ccc(S(=O)(=O)NC(=O)c5ccc(N6CCN(CC7=C(c8ccc(Cl)cc8)CCC(C)(C)C7)CC6)cc5)cc4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C2)cc1
E3 Binder	CHEMBL5283149	ChEMBL	7.33	—	—	Cc1ncsc1-c1ccc2c(c1)OCCOCCOC[C@@H](NC(=O)C[C@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COCCOCCOCC(=O)N[C@@H](C(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NC2
E3 Binder	CHEMBL5290134	ChEMBL	7.6	—	—	Cc1ncsc1-c1ccc2c(c1)OCCOCCO[C@H](NC(=O)C[C@@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COCCOCCOCC(=O)N[C@H](C(C)(C)C)C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NC2
E3 Binder	CHEMBL3683785	ChEMBL	6.16	—	—	O=C(Cc1ccccc1)NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1
E3 Binder	CHEMBL4241500	ChEMBL	8.17	F7B	—	O=C1CCSc2ccc(Cl)cc21
E3 Binder	CHEMBL3683780	ChEMBL	6.07	—	—	O=c1c(-c2cccnc2)c[nH]n1-c1ccc(CO)cn1
E3 Binder	CHEMBL3683779	ChEMBL	6.37	—	—	O=c1c(-c2cccnc2)c[nH]n1-c1ccccn1
E3 Binder	CHEMBL4244103	ChEMBL	8.3	F4K	—	OCc1ccc(-n2cccc2)cc1

VHL

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾