TRI23

Details:

UniProt Entry: P36406
Gene: TRIM23
Class: RING
Family: RING8
Protein length: 574
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 5vzv, 5vzw

Protein Sequence ▾

>P36406
MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL
TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGPIGQY GAAEESIGIS
GESIIRCDED EAHLASVYCT VCATHLCSEC SQVTHSTKTL AKHRRVPLAD KPHEKTMCSQ
HQVHAIEFVC LEEGCQTSPL MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF
TEEISDYSRK LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCIRA YFYDLHETLC
RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSEVSAACL HCEKTLQQDD CRVVLAKQEI
TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG PKMEIRVVTL GLDGAGKTTI
LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD
SSHRDRISEA HSELAKLLTE KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS
WYIQGCDARS GMGLYEGLDW LSRQLVAAGV LDVA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
22	106	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
31	76	Domain	Zinc finger, RING-type	IPR001841	PS50089
31	73	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
31	75	Domain	Zinc finger, RING-type	IPR001841	SM00184
51	60	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
122	168	Domain	B-box-type zinc finger	IPR000315	PS50119
122	168	Domain	B-box-type zinc finger	IPR000315	SM00336
126	168	Domain	B-box-type zinc finger	IPR000315	PF00643
145	172	Domain	Zinc finger C2H2-type	IPR013087	PS50157
173	219	Domain	B-box-type zinc finger	IPR000315	SM00336
226	370	Domain	B-box, C-terminal	IPR003649	SM00502
389	565	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	SM00178
390	569	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
399	564	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	PF00025
402	566	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
402	562	Family	Small GTPase superfamily, ARF type	IPR024156	PTHR11711
404	531	Domain	Small GTP-binding protein domain	IPR005225	TIGR00231
406	429	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	PR00328
434	458	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	PR00328
461	486	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	PR00328
506	527	Family	Small GTPase superfamily, ARF/SAR type	IPR006689	PR00328

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:28871090
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006886	intracellular protein transport	Biological Process	IBA	GO_REF:0000033
GO:0016192	vesicle-mediated transport	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005765	lysosomal membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005525	GTP binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003924	GTPase activity	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15684077
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0008047	enzyme activator activity	Molecular Function	TAS	PMID:8473324
GO:0019003	GDP binding	Molecular Function	IDA	PMID:8700863
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:16189514
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P36406	TRI23	Yes	No	Yes	Yes	25416956, 22493164, 16189514, 32296183	EBI-752821	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.