PCGF2

Details:

UniProt Entry: P35227
Gene: PCGF2
Class: RING
Family: RING4
Protein length: 344
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>P35227
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ
EKGALSDDEI VSLSIEFYEG ARDRDEKKGP LENGDGDKEK TGVRFLRCPA AMTVMHLAKF
LRNKMDVPSK YKVEVLYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT
VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP
TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	108	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
18	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
34	43	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
164	228	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0097190	apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000120
GO:0009952	anterior/posterior pattern specification	Biological Process	IEA	GO_REF:0000107
GO:0048704	embryonic skeletal system morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0048706	embryonic skeletal system development	Biological Process	IEA	GO_REF:0000107
GO:0070301	cellular response to hydrogen peroxide	Biological Process	IEA	GO_REF:0000107
GO:2001234	negative regulation of apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:26151332
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0035102	PRC1 complex	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000117
GO:0001739	sex chromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000107
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:19636380
GO:1990841	promoter-specific chromatin binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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