BMI1

Details:

UniProt Entry: P35226

Gene: BMI1

Class: RING

Family: RING4

Protein length: 326

Database confidence: 1.0

InterPro: InterPro Entry

Mode of Action: Standalone

AlphaFold Model: Link

PDB Structures: 2h0d, 2na1, 3rpg, 4r8p, 5fr6, 6wi7, 6wi8, 7nd1

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
1	108	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
18	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
34	43	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
162	226	Domain	RAWUL domain	IPR032443	PF16207

GO term	Name	Ontology	Evidence	Reference
GO:0097190	apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0001501	skeletal system development	Biological Process	IEA	GO_REF:0000107
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0006346	DNA methylation-dependent constitutive heterochromatin formation	Biological Process	IEA	GO_REF:0000107
GO:0006959	humoral immune response	Biological Process	IEA	GO_REF:0000107
GO:0007420	brain development	Biological Process	IEA	GO_REF:0000107
GO:0021903	rostrocaudal neural tube patterning	Biological Process	IEA	GO_REF:0000107
GO:0048103	somatic stem cell division	Biological Process	IEA	GO_REF:0000107
GO:0048704	embryonic skeletal system morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0048706	embryonic skeletal system development	Biological Process	IEA	GO_REF:0000107
GO:2000011	regulation of adaxial/abaxial pattern formation	Biological Process	IEA	GO_REF:0000107
GO:2001234	negative regulation of apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000120
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:26151332
GO:0007379	segment specification	Biological Process	TAS	PMID:7715727
GO:0010468	regulation of gene expression	Biological Process	IMP	PMID:17420273
GO:0030097	hemopoiesis	Biological Process	IEP	PMID:15334543
GO:0030890	positive regulation of B cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0033092	positive regulation of immature T cell proliferation in thymus	Biological Process	IEA	GO_REF:0000107
GO:0045814	negative regulation of gene expression, epigenetic	Biological Process	IEA	GO_REF:0000117
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IMP	PMID:17420273
GO:0051443	positive regulation of ubiquitin-protein transferase activity	Biological Process	IDA	PMID:16714294
GO:0071347	cellular response to interleukin-1	Biological Process	IEA	GO_REF:0000107
GO:0071549	cellular response to dexamethasone stimulus	Biological Process	IEA	GO_REF:0000107
GO:0090183	regulation of kidney development	Biological Process	IEA	GO_REF:0000107
GO:0000792	heterochromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-3108203
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:16714294
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000107
GO:0035102	PRC1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:15386022
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0071535	RING-like zinc finger domain binding	Molecular Function	IPI	PMID:16714294
GO:0097027	ubiquitin-protein transferase activator activity	Molecular Function	IEA	GO_REF:0000107
GO:1990841	promoter-specific chromatin binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P23921	RIR1	Yes	Yes	No	No	—	No	Cluster-specific
Q99496	RING2	Yes	Yes	Yes	No	20543829, 27705803, 20601937, 32296183, 26496610, 21772249, 22902369, 22493164, 15386022, 19636380, 16710298, 24981860, 34316702	EBI-8056000	Cluster-specific
Q7L7L0	H2A3	Yes	Yes	No	No	—	No	Cluster-specific
O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q93077	H2A1C	Yes	Yes	No	No	—	No	Cluster-specific
Q99878	H2A1J	Yes	Yes	No	No	—	No	Cluster-specific
P20671	H2A1D	Yes	Yes	No	No	—	No	Cluster-specific
Q96KK5	H2A1H	Yes	Yes	No	No	—	No	Cluster-specific

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL5278557	ChEMBL	9.0	—	—	CCc1nc2ccc(F)cc2n1-c1cnnc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5280041	ChEMBL	9.0	—	—	CCc1nc2ccc(F)cc2n1-c1cnnc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5281109	ChEMBL	9.0	—	—	CCc1nc2ccc(F)cc2n1-c1nncc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5285217	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1cnnc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5278972	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1cnnc(Nc2ccc(C)cc2)n1
E3 Binder	CHEMBL5270622	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1cnnc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5272260	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1cnnc(Nc2ccc(OC)cc2)n1
E3 Binder	CHEMBL5275887	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1nncc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5271126	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1nncc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5270834	ChEMBL	9.0	—	—	CCc1nc2ccccc2n1-c1nncc(Nc2ccc(OC)cc2)n1
E3 Binder	CHEMBL5287305	ChEMBL	9.0	—	—	COc1ccc(Nc2cnnc(-n3c(C4CC4)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5272817	ChEMBL	9.0	—	—	COc1ccc(Nc2nncc(-n3c(C)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5282796	ChEMBL	9.0	—	—	Cc1ccc(Nc2nncc(-n3c(C)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5282609	ChEMBL	9.0	—	—	Cc1nc2ccc(F)cc2n1-c1cnnc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5273906	ChEMBL	9.0	—	—	Cc1nc2ccc(F)cc2n1-c1cnnc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5274905	ChEMBL	9.0	—	—	Cc1nc2ccccc2n1-c1cnnc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5266175	ChEMBL	9.0	—	—	Cc1nc2ccccc2n1-c1cnnc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5270667	ChEMBL	9.0	—	—	Cc1nc2ccccc2n1-c1nncc(Nc2ccc(C(F)(F)F)cc2)n1
E3 Binder	CHEMBL5272249	ChEMBL	9.0	—	—	Cc1nc2ccccc2n1-c1nncc(Nc2ccc(OC(F)F)cc2)n1
E3 Binder	CHEMBL5269901	ChEMBL	9.0	—	—	FC(F)(F)c1ccc(Nc2cnnc(-n3c(C4CC4)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5289952	ChEMBL	9.0	—	—	FC(F)(F)c1ccc(Nc2nncc(-n3c(C4CC4)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5282393	ChEMBL	9.0	—	—	FC(F)Oc1ccc(Nc2cnnc(-n3c(C4CC4)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5276953	ChEMBL	9.0	—	—	FC(F)Oc1ccc(Nc2nncc(-n3c(C4CC4)nc4ccccc43)n2)cc1
E3 Binder	CHEMBL5268696	ChEMBL	9.0	—	—	Fc1ccc2nc(C3CC3)n(-c3cnnc(Nc4ccc(C(F)(F)F)cc4)n3)c2c1
E3 Binder	CHEMBL5288239	ChEMBL	9.0	—	—	Fc1ccc2nc(C3CC3)n(-c3nncc(Nc4ccc(C(F)(F)F)cc4)n3)c2c1

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