PML

>P29590
MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC
QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR
QIVDAQAVCT RCKESADFWC FECEQLLCAK CFEAHQWFLK HEARPLAELR NQSVREFLDG
TRKTNNIFCS NPNHRTPTLT SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL
DAMTQALQEQ DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA
VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG FLRQALCRLR
QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKDAAVSK KASPEAASTP RDPIDVDLPE
EAERVKAQVQ ALGLAEAQPM AVVQSVPGAH PVPVYAFSIK GPSYGEDVSN TTTAQKRKCS
QTQCPRKVIK MESEEGKEAR LARSSPEQPR PSTSKAVSPP HLDGPPSPRS PVIGSEVFLP
NSNHVASGAG EAEERVVVIS SSEDSDAENS SSRELDDSSS ESSDLQLEGP STLRVLDENL
ADPQAEDRPL VFFDLKIDNE TQKISQLAAV NRESKFRVVI QPEAFFSIYS KAVSLEVGLQ
HFLSFLSSMR RPILACYKLW GPGLPNFFRA LEDINRLWEF QEAISGFLAA LPLIRERVPG
ASSFKLKNLA QTYLARNMSE RSAMAAVLAM RDLCRLLEVS PGPQLAQHVY PFSSLQCFAS
LQPLVQAAVL PRAEARLLAL HNVSFMELLS AHRRDRQGGL KKYSRYLSLQ TTTLPPAQPA
FNLQALGTYF EGLLEGPALA RAEGVSTPLA GRGLAERASQ QS

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
49	104	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
57	92	Domain	Zinc finger, RING-type	IPR001841	PS50089
57	91	Domain	Zinc finger, RING-type	IPR001841	SM00184
72	81	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
124	166	Domain	B-box-type zinc finger	IPR000315	PS50119
124	166	Domain	B-box-type zinc finger	IPR000315	SM00336
127	166	Domain	B-box-type zinc finger	IPR000315	PF00643
184	222	Domain	B-box-type zinc finger	IPR000315	PS50119
240	570	Family	Protein of unknown function DUF3583	IPR021978	PF12126

GO term	Name	Ontology	Evidence	Reference
GO:0001666	response to hypoxia	Biological Process	IEA	GO_REF:0000117
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0008285	negative regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000117
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Biological Process	IEA	GO_REF:0000117
GO:0010629	negative regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0016525	negative regulation of angiogenesis	Biological Process	IEA	GO_REF:0000117
GO:0030578	PML body organization	Biological Process	IEA	GO_REF:0000117
GO:0034097	response to cytokine	Biological Process	IEA	GO_REF:0000117
GO:0034504	protein localization to nucleus	Biological Process	IEA	GO_REF:0000117
GO:0044790	suppression of viral release by host	Biological Process	IEA	GO_REF:0000117
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000120
GO:0045184	establishment of protein localization	Biological Process	IEA	GO_REF:0000117
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0051246	regulation of protein metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0060341	regulation of cellular localization	Biological Process	IEA	GO_REF:0000117
GO:0065008	regulation of biological quality	Biological Process	IEA	GO_REF:0000117
GO:0090398	cellular senescence	Biological Process	IEA	GO_REF:0000117
GO:2001235	positive regulation of apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0006606	protein import into nucleus	Biological Process	IEA	GO_REF:0000107
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	Biological Process	IEA	GO_REF:0000107
GO:0009411	response to UV	Biological Process	IEA	GO_REF:0000107
GO:0010332	response to gamma radiation	Biological Process	IEA	GO_REF:0000107
GO:0030099	myeloid cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0031503	protein-containing complex localization	Biological Process	IEA	GO_REF:0000107
GO:0045165	cell fate commitment	Biological Process	IEA	GO_REF:0000107
GO:0048384	retinoic acid receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0051457	maintenance of protein location in nucleus	Biological Process	IDA	PMID:17332504
GO:0060395	SMAD protein signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0060444	branching involved in mammary gland duct morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Biological Process	IEA	GO_REF:0000107
GO:0071353	cellular response to interleukin-4	Biological Process	IEA	GO_REF:0000107
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	Biological Process	IEA	GO_REF:0000107
GO:0097191	extrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IMP	PMID:23007646
GO:0010522	regulation of calcium ion transport into cytosol	Biological Process	ISS	GO_REF:0000024
GO:0010761	fibroblast migration	Biological Process	IEA	GO_REF:0000107
GO:0016925	protein sumoylation	Biological Process	IEA	GO_REF:0000041
GO:0030155	regulation of cell adhesion	Biological Process	IEA	GO_REF:0000107
GO:0030308	negative regulation of cell growth	Biological Process	IDA	PMID:9448006
GO:0030330	DNA damage response, signal transduction by p53 class mediator	Biological Process	ISS	GO_REF:0000024
GO:0032206	positive regulation of telomere maintenance	Biological Process	IMP	PMID:26119943
GO:0032469	endoplasmic reticulum calcium ion homeostasis	Biological Process	ISS	GO_REF:0000024
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process	IEA	GO_REF:0000107
GO:0032692	negative regulation of interleukin-1 production	Biological Process	IEA	GO_REF:0000107
GO:0032922	circadian regulation of gene expression	Biological Process	ISS	GO_REF:0000024
GO:0042752	regulation of circadian rhythm	Biological Process	ISS	GO_REF:0000024
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Biological Process	ISS	GO_REF:0000024
GO:0043153	entrainment of circadian clock by photoperiod	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22406621
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:9448006
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IEA	GO_REF:0000107
GO:0065003	protein-containing complex assembly	Biological Process	IDA	PMID:12915590
GO:0090402	oncogene-induced cell senescence	Biological Process	IEA	GO_REF:0000107
GO:1901798	positive regulation of signal transduction by p53 class mediator	Biological Process	IEA	GO_REF:0000107
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:15195100
GO:2000779	regulation of double-strand break repair	Biological Process	IMP	PMID:21639834
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:21803845
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016363	nuclear matrix	Cellular Component	IEA	GO_REF:0000117
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000120
GO:0031901	early endosome membrane	Cellular Component	IEA	GO_REF:0000044
GO:0000781	chromosome, telomeric region	Cellular Component	IDA	PMID:26119943
GO:0005829	cytosol	Cellular Component	ISS	GO_REF:0000024
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003713	transcription coactivator activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:10669754
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019789	SUMO transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:12915590
GO:0032183	SUMO binding	Molecular Function	IPI	PMID:17081985
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:9230084
GO:0046332	SMAD binding	Molecular Function	IEA	GO_REF:0000107
GO:0060090	molecular adaptor activity	Molecular Function	IDA	PMID:20719947
GO:0061659	ubiquitin-like protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity