PEX2

Details:

UniProt Entry: P28328
Gene: PEX2
Class: RING
Family: RING1
Protein length: 305
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>P28328
MASRKENAKS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKACL
WVFLWRFTIY SKNATVGQSV LNIKYKNDFS PNLRYQPPSK NQKIWYAVCT IGGRWLEERC
YDLFRNHHLA SFGKVKQCVN FVIGLLKLGG LINFLIFLQR GKFATLTERL LGIHSVFCKP
QNICEVGFEY MNRELLWHGF AEFLIFLLPL INVQKLKAKL SSWCIPLTGA PNSDNTLATS
GKECALCGEW PTMPHTIGCE HIFCYFCAKS SFLFDVYFTC PKCGTEVHSL QPLKSGIEMS
EVNAL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	224	Domain	Pex, N-terminal	IPR006845	PF04757
234	304	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
244	283	Domain	Zinc finger, RING-type	IPR001841	PS50089
244	283	Domain	Zinc finger, RING-type	IPR001841	SM00184
244	283	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
259	268	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007031	peroxisome organization	Biological Process	IEA	GO_REF:0000002
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016558	protein import into peroxisome matrix	Biological Process	IEA	GO_REF:0000002
GO:0000425	pexophagy	Biological Process	IDA	PMID:26344566
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:27597759
GO:0016562	protein import into peroxisome matrix, receptor recycling	Biological Process	IDA	PMID:16854980
GO:0034614	cellular response to reactive oxygen species	Biological Process	IDA	PMID:26344566
GO:0043335	protein unfolding	Biological Process	IDA	PMID:16854980
GO:0044721	protein import into peroxisome matrix, substrate release	Biological Process	IDA	PMID:26344566
GO:0000038	very long-chain fatty acid metabolic process	Biological Process	IBA	GO_REF:0000033
GO:0006635	fatty acid beta-oxidation	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031648	protein destabilization	Biological Process	IMP	PMID:18987311
GO:0048147	negative regulation of fibroblast proliferation	Biological Process	IMP	PMID:18987311
GO:0050680	negative regulation of epithelial cell proliferation	Biological Process	IMP	PMID:18987311
GO:1990928	response to amino acid starvation	Biological Process	IDA	PMID:27597759
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005777	peroxisome	Cellular Component	IEA	GO_REF:0000043
GO:0005778	peroxisomal membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9603775
GO:0016593	Cdc73/Paf1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:10837480
GO:0008320	protein transmembrane transporter activity	Molecular Function	ISS	PMID:35768507
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:27597759

Enzyme–Substrate Interactions ▾

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