CBL

>P22681
MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT VDKKMVEKCW
KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP SGLFQGDTFR
ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE
FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPQDH
IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM CTSCLTSWQE SEGQGCPFCR
CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA PSPNYDDDDD ERADDTLFMM KELAGAKVER
PPSPFSMAPQ ASLPPVPPRL DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR
DLPPPPPPDR PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN SSPLVGPECD
HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY MTPSSRPLRP LDTSQSSRAC
DCDQQIDSCT YEAMYNIQSQ APSITESSTF GEGNLAAAHA NTGPEESENE DDGYDVPKPP
VPAVLARRTL SDISNASSSF GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC
QQGSGPAASA ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS
PAHVAT

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
23	900	Family	Adaptor protein Cbl	IPR024162	PTHR23007
47	351	Domain	Adaptor protein Cbl, PTB domain	IPR024159	PS51506
47	175	Homologous_superfamily	Adaptor protein Cbl, N-terminal domain superfamily	IPR036537	G3DSA:1.20.930.20
49	177	Homologous_superfamily	Adaptor protein Cbl, N-terminal domain superfamily	IPR036537	SSF47668
52	175	Domain	Adaptor protein Cbl, N-terminal helical	IPR003153	PF02262
178	263	Homologous_superfamily	EF-hand domain pair	IPR011992	SSF47473
179	262	Domain	Adaptor protein Cbl, EF hand-like	IPR014741	PF02761
256	352	Domain	Adaptor protein Cbl, SH2-like domain	IPR014742	cd09920
264	350	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
264	349	Domain	Adaptor protein Cbl, SH2-like domain	IPR014742	PF02762
265	349	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
350	435	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
362	427	Domain	E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass	IPR039520	cd16709
381	419	Domain	Zinc finger, RING-type	IPR001841	SM00184
381	420	Domain	Zinc finger, RING-type	IPR001841	PS50089
396	405	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
843	893	Homologous_superfamily	UBA-like superfamily	IPR009060	SSF46934
856	895	Domain	Ubiquitin-associated domain	IPR015940	PS50030
857	894	Domain	Ubiquitin-associated domain	IPR015940	SM00165
858	892	Domain	Ubiquitin-associated domain	IPR015940	PF00627

GO term	Name	Ontology	Evidence	Reference
GO:0007166	cell surface receptor signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0023051	regulation of signaling	Biological Process	IEA	GO_REF:0000002
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:1902531	regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0032487	regulation of Rap protein signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000107
GO:0007165	signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0008584	male gonad development	Biological Process	IEA	GO_REF:0000107
GO:0010332	response to gamma radiation	Biological Process	IEA	GO_REF:0000107
GO:0014823	response to activity	Biological Process	IEA	GO_REF:0000107
GO:0019221	cytokine-mediated signaling pathway	Biological Process	TAS	Reactome:R-HSA-9607240
GO:0033574	response to testosterone	Biological Process	IEA	GO_REF:0000107
GO:0036120	cellular response to platelet-derived growth factor stimulus	Biological Process	IEA	GO_REF:0000107
GO:0042594	response to starvation	Biological Process	IEA	GO_REF:0000107
GO:0043066	negative regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0043303	mast cell degranulation	Biological Process	IEA	GO_REF:0000107
GO:0045471	response to ethanol	Biological Process	IEA	GO_REF:0000107
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-8849469
GO:0046718	symbiont entry into host cell	Biological Process	TAS	Reactome:R-HSA-8875360
GO:0048260	positive regulation of receptor-mediated endocytosis	Biological Process	IMP	PMID:15465819
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IMP	PMID:17003487
GO:0070086	ubiquitin-dependent endocytosis	Biological Process	IEA	GO_REF:0000107
GO:0071456	cellular response to hypoxia	Biological Process	IEA	GO_REF:0000107
GO:1990090	cellular response to nerve growth factor stimulus	Biological Process	IEA	GO_REF:0000107
GO:2000583	regulation of platelet-derived growth factor receptor-alpha signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005929	cilium	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0045121	membrane raft	Cellular Component	IBA	GO_REF:0000033
GO:0005925	focal adhesion	Cellular Component	IEA	GO_REF:0000107
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000107
GO:0030426	growth cone	Cellular Component	IEA	GO_REF:0000107
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0016600	flotillin complex	Cellular Component	ISS	GO_REF:0000024
GO:0001784	phosphotyrosine residue binding	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005509	calcium ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0017124	SH3 domain binding	Molecular Function	IEA	GO_REF:0000117
GO:0046875	ephrin receptor binding	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:10068674
GO:0019901	protein kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0030971	receptor tyrosine kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Molecular Function	IEA	GO_REF:0000107
GO:0045296	cadherin binding	Molecular Function	HDA	PMID:25468996
GO:1990782	protein tyrosine kinase binding	Molecular Function	IEA	GO_REF:0000107

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P08648	ITA5	Yes	Yes	No	No	—	No	E3-specific
P04085	PDGFA	Yes	Yes	No	No	—	No	E3-specific
P55085	PAR2	Yes	Yes	Yes	No	15708858	EBI-4303858	E3-specific
P07947	YES	Yes	Yes	No	No	35044719	EBI-34606472	E3-specific
P17948	VGFR1	Yes	Yes	No	No	18273061	EBI-7811694	E3-specific
P46109	CRKL	Yes	Yes	Yes	No	8626543, 16982329, 15556646, 8662998, 25814554	EBI-7392219	E3-specific
Q8TBZ2	MYBPP	Yes	Yes	No	No	—	No	E3-specific
P00519	ABL1	Yes	Yes	No	No	15556646	EBI-7392045	Cluster-specific
O94875	SRBS2	Yes	Yes	No	No	—	No	E3-specific
P54762	EPHB1	Yes	Yes	No	No	—	No	E3-specific
Q9UGK3	STAP2	Yes	Yes	No	No	—	No	E3-specific
P40238	TPOR	Yes	Yes	No	No	—	No	E3-specific
Q14155	ARHG7	Yes	Yes	Yes	No	16407834	EBI-8004336	E3-specific
P27986	P85A	Yes	Yes	Yes	No	16219545, 16982329, 7642581, 15556646, 15581361, 8621719, 9160881, 19380743, 8662998, 25814554, 9890970	EBI-8676627	Cluster-specific
P09619	PGFRB	Yes	Yes	No	No	17620338	EBI-7489222	E3-specific
P22607	FGFR3	Yes	Yes	No	No	—	No	E3-specific
P15498	VAV	Yes	Yes	No	No	9200440	EBI-8652627	E3-specific
Q02763	TIE2	Yes	Yes	No	No	—	No	E3-specific
P22455	FGFR4	Yes	Yes	No	No	35384245	EBI-32722168	E3-specific
P48736	PK3CG	Yes	Yes	No	No	—	No	E3-specific
P51692	STA5B	Yes	Yes	No	No	—	No	E3-specific
P06127	CD5	Yes	Yes	No	No	—	No	E3-specific
P42229	STA5A	Yes	Yes	No	No	25814554	EBI-10695862	E3-specific
P21802	FGFR2	Yes	Yes	No	No	—	No	E3-specific
P31785	IL2RG	Yes	Yes	No	No	—	No	E3-specific
P12318	FCG2A	Yes	Yes	No	No	—	No	E3-specific
Q8WU20	FRS2	Yes	Yes	No	No	—	No	E3-specific
P07333	CSF1R	Yes	Yes	No	No	—	No	E3-specific
Q96JA1	LRIG1	Yes	Yes	Yes	No	15282549	EBI-25424876	E3-specific
P11274	BCR	Yes	Yes	No	No	—	No	E3-specific
O95644	NFAC1	Yes	Yes	No	No	—	No	E3-specific
P10721	KIT	Yes	Yes	No	No	—	No	E3-specific
P29322	EPHA8	Yes	Yes	No	No	—	No	E3-specific
Q7Z698	SPRE2	Yes	Yes	No	No	17094949	EBI-7082219	E3-specific