| E3 Binder |
CHEMBL1289419 |
ChEMBL |
6.32 |
— |
— |
CC(C)(CNC(=O)C(C)(O)C(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289299 |
ChEMBL |
6.27 |
— |
— |
CC(C)(CNC(=O)C1(C#N)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289969 |
ChEMBL |
6.25 |
— |
— |
CC(C)(CNC(=O)C1(C#N)CCOCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289186 |
ChEMBL |
6.62 |
— |
— |
CC(C)(CNC(=O)C1(C(F)(F)F)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289530 |
ChEMBL |
6.5 |
— |
— |
CC(C)(CNC(=O)C1(C(F)(F)F)CCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289417 |
ChEMBL |
6.43 |
— |
— |
CC(C)(CNC(=O)C1(C)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289298 |
ChEMBL |
6.1 |
— |
— |
CC(C)(CNC(=O)C1(N)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289743 |
ChEMBL |
6.2 |
— |
— |
CC(C)(CNC(=O)C1(O)CCC(F)(F)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289531 |
ChEMBL |
6.14 |
— |
— |
CC(C)(CNC(=O)C1(O)CCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289639 |
ChEMBL |
6.35 |
— |
— |
CC(C)(CNC(=O)C1(O)CCCCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289416 |
ChEMBL |
6.5 |
— |
— |
CC(C)(CNC(=O)C1CC1(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289068 |
ChEMBL |
6.31 |
— |
— |
CC(C)(CNC(=O)C1CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289850 |
ChEMBL |
6.36 |
— |
— |
CC(C)(CNC(=O)C1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289744 |
ChEMBL |
6.08 |
— |
— |
CC(C)(CNC(=O)C1CCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289968 |
ChEMBL |
6.02 |
— |
— |
CC(C)(CNC(=O)C1CCOCC1(C)C)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290737 |
ChEMBL |
6.57 |
— |
— |
CC(C)(CNC(=O)CC(F)(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290509 |
ChEMBL |
6.39 |
— |
— |
CC(C)(CNC(=O)c1ccco1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290510 |
ChEMBL |
6.44 |
— |
— |
CC(C)(CNC(=O)c1ccoc1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289188 |
ChEMBL |
6.46 |
— |
— |
CC(C)(CNC(=O)c1cnccn1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290739 |
ChEMBL |
6.05 |
— |
— |
CC(C)(CNC(=O)c1cocn1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290621 |
ChEMBL |
6.54 |
— |
— |
CC(C)(CNC(=O)c1cscn1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1289301 |
ChEMBL |
6.34 |
— |
— |
CC(C)(CNC(=O)c1ncccc1O)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL1290618 |
ChEMBL |
6.47 |
— |
— |
CC(C)(CNC(=O)n1cccc1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL3982686 |
ChEMBL |
7.28 |
— |
— |
CCc1ccc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)cc1 |
| E3 Binder |
CHEMBL3943702 |
ChEMBL |
7.22 |
— |
— |
CCc1ccc(OCCCOc2c3ccoc3cc3oc(=O)ccc23)cc1 |
| E3 Binder |
CHEMBL3902465 |
ChEMBL |
6.82 |
— |
— |
COc1cc(OC)cc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)c1 |
| E3 Binder |
CHEMBL3937251 |
ChEMBL |
6.32 |
— |
— |
COc1cc([N+](=O)[O-])ccc1OCCCCOc1c2ccoc2cc2oc(=O)ccc12 |
| E3 Binder |
CHEMBL3961395 |
ChEMBL |
8.0 |
— |
— |
COc1ccc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)cc1 |
| E3 Binder |
CHEMBL3901865 |
ChEMBL |
7.0 |
— |
— |
COc1ccc2sc(SCCCCOc3c4ccoc4cc4oc(=O)ccc34)nc2c1 |
| E3 Binder |
CHEMBL3899683 |
ChEMBL |
7.35 |
— |
— |
COc1cccc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)c1 |
| E3 Binder |
CHEMBL1289300 |
ChEMBL |
6.43 |
— |
— |
COc1cnccc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL317791 |
ChEMBL |
6.8 |
— |
— |
C[C@H](OC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1 |
| E3 Binder |
CHEMBL3894190 |
ChEMBL |
6.61 |
— |
— |
Cc1ccc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)c([N+](=O)[O-])c1 |
| E3 Binder |
CHEMBL3899148 |
ChEMBL |
7.7 |
— |
— |
Cc1ccc(OCCCCOc2c3ccoc3cc3oc(=O)ccc23)cc1 |
| E3 Binder |
CHEMBL3922127 |
ChEMBL |
7.19 |
— |
— |
Cc1ccc(OCCCOc2c3ccoc3cc3oc(=O)ccc23)cc1 |
| E3 Binder |
CHEMBL3932874 |
ChEMBL |
6.0 |
— |
— |
Cc1nnc(SCCCCOc2c3ccoc3cc3oc(=O)ccc23)s1 |
| E3 Binder |
CHEMBL1289070 |
ChEMBL |
6.28 |
— |
— |
Cn1ccnc1C(=O)NCC(C)(C)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL3908386 |
ChEMBL |
6.12 |
— |
— |
O=c1ccc2c(OCCCCOCc3ccccc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3940526 |
ChEMBL |
8.0 |
— |
— |
O=c1ccc2c(OCCCCOc3ccc(Cl)cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3960875 |
ChEMBL |
7.92 |
— |
— |
O=c1ccc2c(OCCCCOc3ccc(F)cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3901953 |
ChEMBL |
6.12 |
— |
— |
O=c1ccc2c(OCCCCOc3ccc(Oc4ccccc4)cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3937779 |
ChEMBL |
6.98 |
— |
— |
O=c1ccc2c(OCCCCOc3ccc([N+](=O)[O-])cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3985258 |
ChEMBL |
7.1 |
— |
— |
O=c1ccc2c(OCCCCOc3ccc4ccccc4c3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3946873 |
ChEMBL |
6.6 |
— |
— |
O=c1ccc2c(OCCCCOc3cccc(C(F)(F)F)c3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3958206 |
ChEMBL |
7.3 |
— |
— |
O=c1ccc2c(OCCCCOc3cccc4ccccc34)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL444449 |
ChEMBL |
7.35 |
— |
— |
O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3953466 |
ChEMBL |
6.8 |
— |
— |
O=c1ccc2c(OCCCCSc3ncccn3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3959937 |
ChEMBL |
6.77 |
— |
— |
O=c1ccc2c(OCCCOCc3ccccc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3930613 |
ChEMBL |
7.6 |
— |
— |
O=c1ccc2c(OCCCOc3ccc(F)cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3946367 |
ChEMBL |
6.6 |
— |
— |
O=c1ccc2c(OCCCOc3ccc(Oc4ccccc4)cc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3928866 |
ChEMBL |
7.17 |
— |
— |
O=c1ccc2c(OCCCOc3cccc(C(F)(F)F)c3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3906400 |
ChEMBL |
7.0 |
— |
— |
O=c1ccc2c(OCCCOc3ccccc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL3953745 |
ChEMBL |
6.96 |
— |
— |
O=c1ccc2c(OCCOCc3ccccc3)c3ccoc3cc2o1 |
| E3 Binder |
CHEMBL4081003 |
ChEMBL |
6.83 |
— |
— |
CC(=O)NC(c1ccccc1-c1cc(Cl)cc(Cl)c1)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4068539 |
ChEMBL |
7.0 |
— |
— |
CC(=O)Nc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1 |
| E3 Binder |
CHEMBL3785765 |
ChEMBL |
6.05 |
— |
— |
CC(C)(C)NC(=O)C1c2ccccc2C(=O)N1Cc1cc(F)ccc1-c1ccc(F)cc1 |
| E3 Binder |
CHEMBL3785335 |
ChEMBL |
6.1 |
— |
— |
CC(C)(C)NC(=O)C1c2ccccc2C(=O)N1Cc1ccc(F)cc1-c1ccccc1 |
| E3 Binder |
CHEMBL3786542 |
ChEMBL |
6.05 |
— |
— |
CC(C)(C)NC(=O)C1c2ccccc2C(=O)N1Cc1ccccc1-c1ccccc1 |
| E3 Binder |
CHEMBL3785198 |
ChEMBL |
6.22 |
— |
— |
CC(C)(CN1C(=O)c2ccccc2C1C(=O)NCCCC(F)F)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL3785768 |
ChEMBL |
6.3 |
— |
— |
CC(C)(CN1C(=O)c2ccccc2C1C(=O)NCCCF)c1ccc(Cl)cc1 |
| E3 Binder |
CHEMBL1289851 |
ChEMBL |
6.11 |
— |
— |
CC(C)(CNC(=O)CC1CCCCO1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 |
| E3 Binder |
CHEMBL3298146 |
ChEMBL |
6.58 |
— |
— |
CC(C)(CNc1noc2cccc(O)c12)c1ccccc1 |
| E3 Binder |
CHEMBL3298141 |
ChEMBL |
6.11 |
— |
— |
CC(C)(CNc1noc2ccccc12)c1ccccc1 |
| E3 Binder |
CHEMBL147381 |
ChEMBL |
6.1 |
— |
— |
CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)OCc1ccccc1 |
| E3 Binder |
CHEMBL146482 |
ChEMBL |
6.52 |
— |
— |
CC(C)C[C@H](NC(=O)c1ccccc1-c1ccccc1CNC(=O)OCc1ccccc1)C(N)=O |
| E3 Binder |
CHEMBL439539 |
ChEMBL |
6.23 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CC(=O)NCCCc1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL384706 |
ChEMBL |
6.39 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CC(=O)NCCc1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL217251 |
ChEMBL |
6.37 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CC(=O)NCc1ccccc1F)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL217684 |
ChEMBL |
6.6 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)CCCc1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL217222 |
ChEMBL |
7.0 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)CCc1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL373704 |
ChEMBL |
6.3 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)CCc1ccccc1Cl)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL385809 |
ChEMBL |
7.44 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)CCc1ccccc1F)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL385960 |
ChEMBL |
6.53 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCCc1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL386975 |
ChEMBL |
6.44 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCc1ccc(Br)cc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL385249 |
ChEMBL |
6.45 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCc1ccc(F)cc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL385662 |
ChEMBL |
6.47 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCc1cccc(F)c1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL386556 |
ChEMBL |
6.12 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCc1ccccc1Cl)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL217620 |
ChEMBL |
6.82 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)NCc1ccccc1F)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL216254 |
ChEMBL |
6.31 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)N[C@@H](C)c1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL216436 |
ChEMBL |
6.55 |
— |
— |
CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)N[C@H](C)c1ccccc1)c1ccccc1)C(C)C |
| E3 Binder |
CHEMBL1088844 |
ChEMBL |
7.52 |
— |
— |
CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL216955 |
ChEMBL |
7.03 |
— |
— |
CC(CC(=O)NCC(c1ccccc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccccc1 |
| E3 Binder |
CHEMBL218128 |
ChEMBL |
6.6 |
— |
— |
CC(NC(=O)CC(c1ccccc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccccc1 |
| E3 Binder |
CHEMBL390106 |
ChEMBL |
6.7 |
— |
— |
CC1(C)Oc2ccc(C(=O)NCCc3ccccc3)cc2[C@@H](NS(=O)(=O)c2ccc(C(F)(F)F)cc2)[C@@H]1O |
| E3 Binder |
CHEMBL228493 |
ChEMBL |
6.82 |
— |
— |
CC1(C)Oc2ccc(C(=O)NCCc3ccccc3)cc2[C@@H](NS(=O)(=O)c2ccccc2OC(F)(F)F)[C@@H]1O |
| E3 Binder |
CHEMBL601672 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCC(c3ccc(F)cc3)C2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL479618 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCC(c3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL518717 |
ChEMBL |
6.01 |
— |
— |
CC1=C(C(=O)N2CCC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465276 |
ChEMBL |
6.18 |
— |
— |
CC1=C(C(=O)N2CCCC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL605576 |
ChEMBL |
7.16 |
— |
— |
CC1=C(C(=O)N2CCCC2c2ccc(F)cc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL605992 |
ChEMBL |
6.82 |
— |
— |
CC1=C(C(=O)N2CCCC2c2ccccc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL601456 |
ChEMBL |
6.18 |
— |
— |
CC1=C(C(=O)N2CCCC2c2ccccn2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL601247 |
ChEMBL |
6.51 |
— |
— |
CC1=C(C(=O)N2CCCC2c2ccncc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465277 |
ChEMBL |
7.05 |
— |
— |
CC1=C(C(=O)N2CCCCC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL518718 |
ChEMBL |
6.72 |
— |
— |
CC1=C(C(=O)N2CCCCCC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL601641 |
ChEMBL |
6.96 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2042162 |
ChEMBL |
7.14 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2cc3ccccc3n2C)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2042158 |
ChEMBL |
7.0 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2042157 |
ChEMBL |
6.78 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL2042159 |
ChEMBL |
6.64 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C3CC3)cc2N1 |
| E3 Binder |
CHEMBL2042156 |
ChEMBL |
7.08 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2042160 |
ChEMBL |
6.55 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2nc3ccccc3s2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL602854 |
ChEMBL |
7.05 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2cc(C)on2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2042154 |
ChEMBL |
7.0 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2ccc(F)cc2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL602070 |
ChEMBL |
7.3 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2ccc(F)cc2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL606204 |
ChEMBL |
6.52 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2nc(C)c(C)s2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL600211 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2nc(C)no2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL601035 |
ChEMBL |
6.32 |
— |
— |
CC1=C(C(=O)N2CCC[C@H]2c2nnn(C)n2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL480990 |
ChEMBL |
6.38 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cc(C)cc(C)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465124 |
ChEMBL |
6.85 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cc(Cl)cc(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL464068 |
ChEMBL |
6.09 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cc(Cl)ccc2Cl)n2nccc2N1 |
| E3 Binder |
CHEMBL521104 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cc3ccccc3o2)n2nccc2N1 |
| E3 Binder |
CHEMBL480796 |
ChEMBL |
6.12 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(C)c(C)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2042149 |
ChEMBL |
6.38 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2042147 |
ChEMBL |
6.91 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL2042151 |
ChEMBL |
6.68 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nc(Cl)cc2N1 |
| E3 Binder |
CHEMBL464077 |
ChEMBL |
6.92 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465939 |
ChEMBL |
6.36 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)cc2)n2nccc2N1 |
| E3 Binder |
CHEMBL464067 |
ChEMBL |
6.55 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)cc2Cl)n2nccc2N1 |
| E3 Binder |
CHEMBL480019 |
ChEMBL |
6.64 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc(Cl)s2)n2nccc2N1 |
| E3 Binder |
CHEMBL467631 |
ChEMBL |
6.19 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2ccc3ccccc3c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465125 |
ChEMBL |
6.27 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cccc(C)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465930 |
ChEMBL |
6.72 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cccc(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL464066 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2cccc(Cl)c2Cl)n2nccc2N1 |
| E3 Binder |
CHEMBL481399 |
ChEMBL |
6.7 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)C(c2sc3ccccc3c2C)n2nccc2N1 |
| E3 Binder |
CHEMBL482381 |
ChEMBL |
7.16 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL480020 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccc(F)cc3)CC2)[C@@H](c2cccc(Cl)c2Cl)n2nccc2N1 |
| E3 Binder |
CHEMBL2042148 |
ChEMBL |
6.83 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL517078 |
ChEMBL |
7.07 |
— |
— |
CC1=C(C(=O)N2CCN(c3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL517791 |
ChEMBL |
7.0 |
— |
— |
CC1=C(C(=O)NCCc2ccccc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465086 |
ChEMBL |
6.8 |
— |
— |
CC1=C(C(=O)NCc2ccccc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL465085 |
ChEMBL |
6.77 |
— |
— |
CC1=C(C(=O)Nc2ccccc2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL565312 |
ChEMBL |
7.19 |
— |
— |
CC1=C(c2nc3c(F)cccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL567025 |
ChEMBL |
6.66 |
— |
— |
CC1=C(c2nc3cc(C#N)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL585353 |
ChEMBL |
6.27 |
— |
— |
CC1=C(c2nc3cc(C(F)(F)F)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL585923 |
ChEMBL |
6.7 |
— |
— |
CC1=C(c2nc3cc(C)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL585123 |
ChEMBL |
7.03 |
— |
— |
CC1=C(c2nc3cc(Cl)ccc3n2C(C)C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL566382 |
ChEMBL |
7.17 |
— |
— |
CC1=C(c2nc3cc(Cl)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL571976 |
ChEMBL |
7.82 |
— |
— |
CC1=C(c2nc3cc(F)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL569493 |
ChEMBL |
6.01 |
— |
— |
CC1=C(c2nc3ccc(C)cc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL567024 |
ChEMBL |
6.18 |
— |
— |
CC1=C(c2nc3ccc(Cl)cc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL566811 |
ChEMBL |
6.54 |
— |
— |
CC1=C(c2nc3ccc(F)cc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL583857 |
ChEMBL |
6.82 |
— |
— |
CC1=C(c2nc3cccc(C)c3[nH]2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL569269 |
ChEMBL |
6.96 |
— |
— |
CC1=C(c2nc3cccc(C)c3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL566800 |
ChEMBL |
7.15 |
— |
— |
CC1=C(c2nc3cccc(Cl)c3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL584709 |
ChEMBL |
6.82 |
— |
— |
CC1=C(c2nc3cccc(F)c3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL569268 |
ChEMBL |
6.29 |
— |
— |
CC1=C(c2nc3ccccc3[nH]2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL577300 |
ChEMBL |
7.12 |
— |
— |
CC1=C(c2nc3ccccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL584937 |
ChEMBL |
6.13 |
— |
— |
CC1=C(c2nc3ccccc3s2)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2332451 |
ChEMBL |
6.69 |
— |
— |
CC1=C(c2nccn2C(C)C)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332461 |
ChEMBL |
6.14 |
— |
— |
CC1=C(c2ncn(-c3ccccc3C)n2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL2332445 |
ChEMBL |
6.39 |
— |
— |
CC1=C(c2ncnn2-c2cc(C)ccn2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332457 |
ChEMBL |
7.1 |
— |
— |
CC1=C(c2ncnn2-c2ccc(C)cc2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2332446 |
ChEMBL |
6.41 |
— |
— |
CC1=C(c2ncnn2-c2ccc(C)cn2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332453 |
ChEMBL |
6.94 |
— |
— |
CC1=C(c2ncnn2-c2ccc(F)cc2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2332443 |
ChEMBL |
7.02 |
— |
— |
CC1=C(c2ncnn2-c2cccc(C(F)(F)F)n2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332447 |
ChEMBL |
6.68 |
— |
— |
CC1=C(c2ncnn2-c2cccc(C)n2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332444 |
ChEMBL |
6.72 |
— |
— |
CC1=C(c2ncnn2-c2cccc(Cl)n2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332454 |
ChEMBL |
7.01 |
— |
— |
CC1=C(c2ncnn2-c2cccc(F)c2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2332442 |
ChEMBL |
6.59 |
— |
— |
CC1=C(c2ncnn2-c2cccc(F)n2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2332455 |
ChEMBL |
7.13 |
— |
— |
CC1=C(c2ncnn2-c2ccccc2F)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331988 |
ChEMBL |
6.65 |
— |
— |
CC1=C(c2ncnn2C(C)(C)C)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331986 |
ChEMBL |
7.05 |
— |
— |
CC1=C(c2ncnn2C(C)C)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331983 |
ChEMBL |
6.88 |
— |
— |
CC1=C(c2ncnn2C2CCC(C(F)(F)F)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2331998 |
ChEMBL |
6.55 |
— |
— |
CC1=C(c2ncnn2C2CCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(C)(C)C)cc2N1 |
| E3 Binder |
CHEMBL2331999 |
ChEMBL |
6.78 |
— |
— |
CC1=C(c2ncnn2C2CCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2331996 |
ChEMBL |
7.03 |
— |
— |
CC1=C(c2ncnn2C2CCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL2331990 |
ChEMBL |
7.32 |
— |
— |
CC1=C(c2ncnn2C2CCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331989 |
ChEMBL |
7.43 |
— |
— |
CC1=C(c2ncnn2C2CCCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331997 |
ChEMBL |
6.9 |
— |
— |
CC1=C(c2ncnn2C2CCCCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nc(C)cc2N1 |
| E3 Binder |
CHEMBL2331987 |
ChEMBL |
7.23 |
— |
— |
CC1=C(c2ncnn2C2CCCCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331992 |
ChEMBL |
6.7 |
— |
— |
CC1=C(c2ncnn2CC(F)(F)F)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331991 |
ChEMBL |
6.64 |
— |
— |
CC1=C(c2ncnn2CC2CC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331993 |
ChEMBL |
6.82 |
— |
— |
CC1=C(c2ncnn2CCC(F)(F)F)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2331994 |
ChEMBL |
6.99 |
— |
— |
CC1=C(c2ncnn2CCCC(F)(F)F)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL2332465 |
ChEMBL |
6.87 |
— |
— |
CC1=C(c2ncnn2Cc2ccccc2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL517025 |
ChEMBL |
6.24 |
— |
— |
CCCCCN(CCCCC)C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL480611 |
ChEMBL |
6.23 |
— |
— |
CCCCCNC(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL468514 |
ChEMBL |
7.16 |
— |
— |
CCCCCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL520917 |
ChEMBL |
6.51 |
— |
— |
CCCCN(CCCC)C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL230671 |
ChEMBL |
7.24 |
— |
— |
CCCCN([C@@H]1c2cc(C(=O)NCCc3ccccc3)ccc2OC(C)(C)[C@H]1O)S(=O)(=O)c1ccc(CC)cc1 |
| E3 Binder |
CHEMBL481396 |
ChEMBL |
6.36 |
— |
— |
CCCCNC(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL3785486 |
ChEMBL |
6.16 |
— |
— |
CCCCNC(=O)C1c2ccccc2C(=O)N1CC(C)c1ccc(Cl)cc1 |
| E3 Binder |
CHEMBL3785933 |
ChEMBL |
6.05 |
— |
— |
CCCCNC(=O)C1c2ccccc2C(=O)N1CC(C)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL42934 |
ChEMBL |
6.85 |
— |
— |
CCCCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL4451245 |
ChEMBL |
6.58 |
— |
— |
CCCN(CC)[C@@H](c1ccccn1)[C@H](c1cccc(C#N)c1)N(CCOC)C[C@@H](C)CO |
| E3 Binder |
CHEMBL4527638 |
ChEMBL |
6.41 |
— |
— |
CCCN(CC)[C@H](c1ccccn1)[C@@H](c1cccc(C#N)c1)N(CCOC)C[C@H](C)CO |
| E3 Binder |
CHEMBL480807 |
ChEMBL |
7.16 |
— |
— |
CCCN(CCC)C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL4476275 |
ChEMBL |
6.66 |
— |
— |
CCCN(CCC)[C@H](c1ccccn1)[C@@H](c1ccccn1)N(CCC)CCC |
| E3 Binder |
CHEMBL4475999 |
ChEMBL |
7.22 |
— |
— |
CCCN(CCC)[C@H](c1ccccn1)[C@@H](c1ccccn1)N(CCC)C[C@H](O)CO |
| E3 Binder |
CHEMBL2312920 |
ChEMBL |
6.7 |
— |
— |
CCCN(c1cccc(C#N)c1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2312921 |
ChEMBL |
6.03 |
— |
— |
CCCN(c1cccc(S(C)(=O)=O)c1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2312933 |
ChEMBL |
6.92 |
— |
— |
CCCN(c1cccnc1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2312918 |
ChEMBL |
6.23 |
— |
— |
CCCN(c1ccon1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2313230 |
ChEMBL |
6.0 |
— |
— |
CCCN(c1cncnc1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL3729766 |
ChEMBL |
6.24 |
— |
— |
CCCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL447625 |
ChEMBL |
6.31 |
— |
— |
CCCNC(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL3786344 |
ChEMBL |
6.4 |
— |
— |
CCCNC(=O)C1c2ccccc2C(=O)N1CC(C)c1ccc(Cl)cc1 |
| E3 Binder |
CHEMBL2312928 |
ChEMBL |
6.12 |
— |
— |
CCCNC(c1cccnc1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL466838 |
ChEMBL |
7.05 |
— |
— |
CCCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL3730685 |
ChEMBL |
6.51 |
— |
— |
CCCc1ncccc1CN(CCCOc1ccc2c(c1)N(C)C(=O)C(C)(C)C(=O)N2CC)CCn1ccc2oc(C)cc2c1=O.Cl.Cl |
| E3 Binder |
CHEMBL567235 |
ChEMBL |
7.32 |
— |
— |
CCCn1c(C2=C(C)Nc3ccnn3C2c2ccc(Cl)c(Cl)c2)nc2cc(F)ccc21 |
| E3 Binder |
CHEMBL2331985 |
ChEMBL |
6.99 |
— |
— |
CCCn1ncnc1C1=C(C)Nc2ccnn2[C@@H]1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL519762 |
ChEMBL |
6.36 |
— |
— |
CCN(CC)C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL1091162 |
ChEMBL |
6.63 |
— |
— |
CCN(CC)C(c1ccccc1)C(O)(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL3623052 |
ChEMBL |
7.28 |
— |
— |
CCN(CC)S(=O)(=O)N[C@H]1CC[C@](CNC2=NS(=O)(=O)c3cccc(OC)c32)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL3987081 |
ChEMBL |
6.21 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CCCN(CCn3ccc4oc(C)cc4c3=O)Cc3ccncc3)ccc21 |
| E3 Binder |
CHEMBL3985376 |
ChEMBL |
6.07 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CN(CCc3cccnc3)C(=O)Cc3cn(C)c4ccccc34)ccc21 |
| E3 Binder |
CHEMBL3967653 |
ChEMBL |
6.2 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(CN(CCn3ccc4oc(C)cc4c3=O)Cc3cccnc3COC)ccc21 |
| E3 Binder |
CHEMBL3731401 |
ChEMBL |
6.8 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3cccc(C#N)c3)ccc21 |
| E3 Binder |
CHEMBL3729664 |
ChEMBL |
6.54 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccccc3)ccc21 |
| E3 Binder |
CHEMBL3727564 |
ChEMBL |
6.75 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccccc3-c3cccnc3)ccc21 |
| E3 Binder |
CHEMBL3731323 |
ChEMBL |
6.4 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL3729196 |
ChEMBL |
6.55 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccncc3C)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL3727860 |
ChEMBL |
6.01 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)S(=O)(=O)c3ccccc3)ccc21.Cl |
| E3 Binder |
CHEMBL3731066 |
ChEMBL |
6.62 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3c(=O)ccc4ccccc43)Cc3ccncc3)ccc21 |
| E3 Binder |
CHEMBL3729229 |
ChEMBL |
6.82 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccccc4c3=O)Cc3ccc(C#N)cc3)ccc21 |
| E3 Binder |
CHEMBL3729281 |
ChEMBL |
6.57 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccccc4c3=O)Cc3ccco3)ccc21 |
| E3 Binder |
CHEMBL3733073 |
ChEMBL |
6.75 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccccc4c3=O)Cc3ccncc3)ccc21.Cl.Cl |
| E3 Binder |
CHEMBL3729291 |
ChEMBL |
6.72 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccccc4c3=O)Cc3ccsc3)ccc21 |
| E3 Binder |
CHEMBL3731879 |
ChEMBL |
6.44 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccccc4c3=O)S(=O)(=O)c3ccccc3)ccc21 |
| E3 Binder |
CHEMBL3729998 |
ChEMBL |
6.8 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccoc4c3=O)Cc3ccc(C#N)cc3)ccc21 |
| E3 Binder |
CHEMBL3729852 |
ChEMBL |
6.72 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccoc4c3=O)Cc3ccc(C(F)(F)F)cc3)ccc21 |
| E3 Binder |
CHEMBL3729497 |
ChEMBL |
6.66 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccoc4c3=O)Cc3ccccc3C)ccc21 |
| E3 Binder |
CHEMBL3732734 |
ChEMBL |
6.75 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccoc4c3=O)Cc3cccs3)ccc21 |
| E3 Binder |
CHEMBL3732294 |
ChEMBL |
6.42 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4ccsc4c3=O)Cc3ccncc3)ccc21 |
| E3 Binder |
CHEMBL3730746 |
ChEMBL |
6.36 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4oc(C)cc4c3=O)Cc3ccncc3)ccc21.Cl.Cl |
| E3 Binder |
CHEMBL3733333 |
ChEMBL |
6.48 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4oc(C)cc4c3=O)Cc3cnccc3C)ccc21 |
| E3 Binder |
CHEMBL3730396 |
ChEMBL |
6.12 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4occc4c3=O)Cc3ccc(C)nc3C)ccc21.Cl.Cl |
| E3 Binder |
CHEMBL3730145 |
ChEMBL |
6.41 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4occc4c3=O)Cc3cccnc3)ccc21 |
| E3 Binder |
CHEMBL3731925 |
ChEMBL |
6.36 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4occc4c3=O)Cc3cccnc3C)ccc21 |
| E3 Binder |
CHEMBL3730543 |
ChEMBL |
6.34 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4occc4c3=O)Cc3cnccc3C)ccc21 |
| E3 Binder |
CHEMBL3728819 |
ChEMBL |
6.38 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4sccc4c3=O)Cc3cccnc3)ccc21 |
| E3 Binder |
CHEMBL3729707 |
ChEMBL |
6.3 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCn3ccc4sccc4c3=O)Cc3cccnc3C)ccc21 |
| E3 Binder |
CHEMBL3732894 |
ChEMBL |
6.24 |
— |
— |
CCN1C(=O)C(C)(C)C(=O)N(CC)c2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL3622348 |
ChEMBL |
7.19 |
— |
— |
CCNC(=O)O[C@H]1CC[C@](CNC2=NS(=O)(=O)c3cccc(OC)c32)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL3298232 |
ChEMBL |
6.86 |
— |
— |
CCNC(=O)O[C@H]1CC[C@](CNc2n[nH]c3cccc(OC)c23)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL3298231 |
ChEMBL |
7.06 |
— |
— |
CCNC(=O)O[C@H]1CC[C@](CNc2nn(C)c3cccc(OC)c23)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL3622358 |
ChEMBL |
7.26 |
— |
— |
CCOC(=O)N[C@H]1CC[C@](CNC2=NS(=O)(=O)c3cccc(OC)c32)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL2332452 |
ChEMBL |
7.01 |
— |
— |
CCOCCn1ccnc1C1=C(C)Nc2cc(C(F)(F)F)nn2[C@@H]1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL570805 |
ChEMBL |
6.11 |
— |
— |
CCOc1ccc(CCN2C(=O)N(NS(C)(=O)=O)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL2332449 |
ChEMBL |
6.65 |
— |
— |
CCOc1cccc(-n2ncnc2C2=C(C)Nc3cc(C(F)(F)F)nn3[C@@H]2c2ccc(Cl)c(Cl)c2)n1 |
| E3 Binder |
CHEMBL3622362 |
ChEMBL |
7.22 |
— |
— |
CCS(=O)(=O)N[C@H]1CC[C@](CNC2=NS(=O)(=O)c3cccc(OC)c32)(c2ccccc2)CC1 |
| E3 Binder |
CHEMBL318879 |
ChEMBL |
6.3 |
— |
— |
CC[C@H](NC(=O)c1cc(OC)ccc1NS(=O)(=O)c1ccc(C)cc1)c1ccccc1 |
| E3 Binder |
CHEMBL94296 |
ChEMBL |
6.16 |
— |
— |
CC[C@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccc(C)cc1)c1ccccc1 |
| E3 Binder |
CHEMBL327816 |
ChEMBL |
6.22 |
— |
— |
CC[C@H](NC(=O)c1ccccc1NS(=O)(=O)c1ccc(OC)cc1)c1ccccc1 |
| E3 Binder |
CHEMBL273418 |
ChEMBL |
6.22 |
— |
— |
CC[C@H](NC(=O)c1ccccc1NS(=O)(=O)c1cccc2cccnc12)c1ccccc1 |
| E3 Binder |
CHEMBL230776 |
ChEMBL |
6.92 |
— |
— |
CCc1ccc(S(=O)(=O)N(CC(C)(C)C)[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL396551 |
ChEMBL |
6.5 |
— |
— |
CCc1ccc(S(=O)(=O)N(CC(C)C)[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL230775 |
ChEMBL |
6.55 |
— |
— |
CCc1ccc(S(=O)(=O)N(Cc2c[nH]cn2)[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL230238 |
ChEMBL |
6.92 |
— |
— |
CCc1ccc(S(=O)(=O)N(Cc2ccccn2)[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL230564 |
ChEMBL |
6.89 |
— |
— |
CCc1ccc(S(=O)(=O)N(Cc2cccnc2)[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL239805 |
ChEMBL |
6.82 |
— |
— |
CCc1ccc(S(=O)(=O)NC2CCc3ccc(NC(=O)c4cccc(OC)c4)cc32)cc1 |
| E3 Binder |
CHEMBL241513 |
ChEMBL |
6.62 |
— |
— |
CCc1ccc(S(=O)(=O)NCc2cccc(NC(=O)c3cccc(OC)c3)c2)cc1 |
| E3 Binder |
CHEMBL391488 |
ChEMBL |
6.06 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3c(cccc3NC(=O)c3cccc(OC)c3)C[C@H]2O)cc1 |
| E3 Binder |
CHEMBL388538 |
ChEMBL |
6.55 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(C)c4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL228330 |
ChEMBL |
7.11 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)CCNc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL258934 |
ChEMBL |
6.21 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)Cc4c(F)cccc4Cl)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL259666 |
ChEMBL |
6.22 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)Cc4ccc(OC)cc4)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL228277 |
ChEMBL |
6.77 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)Cc4ccccc4F)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL228813 |
ChEMBL |
6.68 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)[C@@H]4CCN(Cc5ccccc5)C4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL389096 |
ChEMBL |
6.77 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)[C@H]4CCN(Cc5ccccc5)C4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL258802 |
ChEMBL |
6.04 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)c4cc(F)ccc4F)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL408935 |
ChEMBL |
6.11 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)c4cccc(C)c4)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL407161 |
ChEMBL |
6.19 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)c4cccc(Cl)c4)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL406415 |
ChEMBL |
6.42 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N(CC)c4ccccc4)cnc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL230251 |
ChEMBL |
6.89 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N4CCC[C@@H]4CNc4c(C)cccc4C)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL387993 |
ChEMBL |
7.22 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)N4CCC[C@H]4CNc4c(C)cccc4C)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL228329 |
ChEMBL |
6.58 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL259118 |
ChEMBL |
6.5 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)Nc4ccc(Br)cc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL231300 |
ChEMBL |
6.58 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)Nc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL388762 |
ChEMBL |
7.1 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)n4nc(-c5ccccc5)cc4N)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL387950 |
ChEMBL |
6.62 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(CNCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467478 |
ChEMBL |
6.7 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)/C=C/c4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467479 |
ChEMBL |
6.37 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)C#Cc4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL466224 |
ChEMBL |
6.6 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)CCc4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL466858 |
ChEMBL |
6.21 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)NCc4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL466646 |
ChEMBL |
6.64 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)OCc4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL524191 |
ChEMBL |
6.66 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)[C@H]4CCCN4Cc4cccc(Cl)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL475630 |
ChEMBL |
6.54 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)[C@H]4CCCN4Cc4cccc(OC(F)(F)F)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL494025 |
ChEMBL |
6.52 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)[C@H]4CCCN4Cc4cccc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL512242 |
ChEMBL |
6.46 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)[C@H]4C[C@@H]4c4ccccc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467672 |
ChEMBL |
6.19 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cc(OC)cc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467671 |
ChEMBL |
6.47 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4ccc(Cl)cc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467041 |
ChEMBL |
6.35 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4ccc(OC)cc4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL512460 |
ChEMBL |
6.15 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(Cl)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL239808 |
ChEMBL |
6.7 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3CCC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL239807 |
ChEMBL |
6.36 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL398397 |
ChEMBL |
6.52 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3C[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL288131 |
ChEMBL |
7.48 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3C[C@H]2O)cc1 |
| E3 Binder |
CHEMBL231203 |
ChEMBL |
6.54 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL467040 |
ChEMBL |
6.35 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(NC(=O)c4ccccc4OC)ccc3CC[C@H]2O)cc1 |
| E3 Binder |
CHEMBL390128 |
ChEMBL |
6.29 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@@H]2c3cc(S(=O)(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL228809 |
ChEMBL |
6.96 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2CC(C)(C)Oc3ccc(C(=O)N4CCC[C@H]4CNc4c(C)cccc4C)cc32)cc1 |
| E3 Binder |
CHEMBL260684 |
ChEMBL |
7.34 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2CCCc3ccc(N(Cc4cccc(C)n4)C(=O)CCc4ccccc4)cc32)cc1 |
| E3 Binder |
CHEMBL513656 |
ChEMBL |
6.55 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2CCCc3ccc(NC(=O)CCc4ccccc4)cc32)cc1 |
| E3 Binder |
CHEMBL513486 |
ChEMBL |
6.23 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2CCCc3ccc(NC(=O)c4cccc(OC)c4)cc32)cc1 |
| E3 Binder |
CHEMBL389892 |
ChEMBL |
6.66 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2c3cc(C(=O)N(CC)[C@@H]4CCN(Cc5ccccc5)C4)ccc3OC(C)(C)[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL438665 |
ChEMBL |
6.7 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2c3cc(C(=O)N(CC)[C@H]4CCN(Cc5ccccc5)C4)ccc3OC(C)(C)[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL228808 |
ChEMBL |
7.05 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2c3cc(C(=O)N4CCC[C@@H]4CNc4c(C)cccc4C)ccc3OC(C)(C)[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL389891 |
ChEMBL |
6.58 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2c3cc(C(=O)N4CCC[C@H]4CNc4c(C)cccc4C)ccc3OC(C)(C)[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL391455 |
ChEMBL |
6.12 |
— |
— |
CCc1ccc(S(=O)(=O)N[C@H]2c3cc(NC(=O)c4cccc(OC)c4)ccc3C[C@@H]2O)cc1 |
| E3 Binder |
CHEMBL3298145 |
ChEMBL |
6.66 |
— |
— |
CCc1cccc2onc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3924627 |
ChEMBL |
6.5 |
— |
— |
CCn1c(=O)ccc2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21 |
| E3 Binder |
CHEMBL567244 |
ChEMBL |
7.24 |
— |
— |
CCn1c(C2=C(C)Nc3ccnn3C2c2ccc(Cl)c(Cl)c2)nc2cc(Cl)ccc21 |
| E3 Binder |
CHEMBL2332450 |
ChEMBL |
6.89 |
— |
— |
CCn1ccnc1C1=C(C)Nc2cc(C(F)(F)F)nn2[C@@H]1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL2331984 |
ChEMBL |
6.72 |
— |
— |
CCn1ncnc1C1=C(C)Nc2ccnn2[C@@H]1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL4094185 |
ChEMBL |
6.94 |
— |
— |
CN(C)C(=O)c1cccc(-c2ccc(F)cc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4100226 |
ChEMBL |
7.19 |
— |
— |
CN(C)C(=O)c1cccc(-c2ccccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4080956 |
ChEMBL |
6.79 |
— |
— |
CN(C)C(=O)c1cccc(-c2ncccc2CC(c2ccnc(N)n2)c2cccnc2F)c1 |
| E3 Binder |
CHEMBL1090817 |
ChEMBL |
6.07 |
— |
— |
CN(C)C(c1ccccc1)C(O)(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4078271 |
ChEMBL |
6.48 |
— |
— |
CN(C)c1ccc(-c2cccc3nc(-c4cncnc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL3729169 |
ChEMBL |
6.16 |
— |
— |
CN(CCN(CCCOc1ccc2c(c1)N(C)C(=O)C(C)(C)C(=O)N2C)Cc1ccncc1)C(=O)c1ccccc1.Cl.Cl |
| E3 Binder |
CHEMBL4080304 |
ChEMBL |
7.05 |
— |
— |
CN(c1cccnc1)c1ncccc1CC(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL3729344 |
ChEMBL |
6.68 |
— |
— |
CN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccnc4ccccc34)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL3728509 |
ChEMBL |
6.27 |
— |
— |
CN1C(=O)C(C)(C)C(=O)N(C)c2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21.Cl.Cl.Cl |
| E3 Binder |
CHEMBL3127404 |
ChEMBL |
6.68 |
— |
— |
CN1C(=O)CC[C@H]1CN(Cc1ccc(Cl)cc1)S(=O)(=O)c1cccc(C#N)c1 |
| E3 Binder |
CHEMBL3127398 |
ChEMBL |
6.09 |
— |
— |
CN1C(=O)CC[C@H]1CN(Cc1ccc(F)cc1)S(=O)(=O)c1cccc(C#N)c1 |
| E3 Binder |
CHEMBL411970 |
ChEMBL |
6.67 |
— |
— |
COC(=O)CC(c1ccc(C#N)cc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL386441 |
ChEMBL |
6.95 |
— |
— |
COC(=O)CC(c1cccc(-c2c(C)noc2C)c1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL217011 |
ChEMBL |
6.86 |
— |
— |
COC(=O)CC(c1cccc(Br)c1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL385737 |
ChEMBL |
6.74 |
— |
— |
COC(=O)CC(c1cccc(C#N)c1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL216086 |
ChEMBL |
6.6 |
— |
— |
COC(=O)CC(c1ccccc1)C(C(=O)N(C(C)C)C(C)C)c1ccccc1 |
| E3 Binder |
CHEMBL217921 |
ChEMBL |
6.83 |
— |
— |
COC(=O)CC(c1cccnc1)C(C(=O)N(C(C)C)C(C)C)c1cccc(Br)c1 |
| E3 Binder |
CHEMBL386226 |
ChEMBL |
6.49 |
— |
— |
COC(=O)CC(c1cccnc1)C(C(=O)N(C(C)C)C(C)C)c1cccc(C#N)c1 |
| E3 Binder |
CHEMBL384974 |
ChEMBL |
6.58 |
— |
— |
COC(=O)CC(c1cccnc1)C(C(=O)N(C(C)C)C(C)C)c1ccccc1 |
| E3 Binder |
CHEMBL216310 |
ChEMBL |
6.15 |
— |
— |
COC(=O)CC(c1cccnc1)C(C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL383874 |
ChEMBL |
6.58 |
— |
— |
COC(=O)C[C@@H](c1ccccc1)[C@H](C(=O)N(C(C)C)C(C)C)c1cccnc1 |
| E3 Binder |
CHEMBL603705 |
ChEMBL |
6.82 |
— |
— |
COC(=O)[C@@H]1CCCN1C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL567234 |
ChEMBL |
6.7 |
— |
— |
COC(=O)c1ccc2c(c1)nc(C1=C(C)Nc3ccnn3C1c1ccc(Cl)c(Cl)c1)n2C |
| E3 Binder |
CHEMBL2042163 |
ChEMBL |
6.82 |
— |
— |
COCC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2cc3ccccc3n2C)n2nc(C(F)(F)F)cc2N1 |
| E3 Binder |
CHEMBL2042152 |
ChEMBL |
7.16 |
— |
— |
COCC1=C(C(=O)N2CCC[C@H]2c2cc(C)no2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL567671 |
ChEMBL |
7.52 |
— |
— |
COCC1=C(c2nc3cc(F)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 |
| E3 Binder |
CHEMBL1092574 |
ChEMBL |
6.23 |
— |
— |
COCCN(C)C(c1ccccc1)C(O)(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL2313227 |
ChEMBL |
6.21 |
— |
— |
COCCN(c1cccnc1)P(=O)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL520586 |
ChEMBL |
6.7 |
— |
— |
COC[C@@H]1CCCN1C(=O)C1=C(C)Nc2ccnn2C1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL583430 |
ChEMBL |
7.0 |
— |
— |
COc1ccc(CCCN2C(=O)N(NS(C)(=O)=O)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL570360 |
ChEMBL |
6.25 |
— |
— |
COc1ccc(CCCN2C(=O)N(NS(C)(=O)=O)C[C@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL570815 |
ChEMBL |
6.64 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(=O)(=O)CC#N)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL571039 |
ChEMBL |
6.05 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(=O)(=O)CF)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL569628 |
ChEMBL |
6.47 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(=O)(=O)Cc3ccccc3)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL568957 |
ChEMBL |
6.22 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(=O)(=O)Cc3cccnc3)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL571041 |
ChEMBL |
6.6 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(C(F)(F)F)cc2)cc1 |
| E3 Binder |
CHEMBL585163 |
ChEMBL |
6.21 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(C)c(C)c2)cc1 |
| E3 Binder |
CHEMBL572153 |
ChEMBL |
6.62 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(C)cc2)cc1 |
| E3 Binder |
CHEMBL583254 |
ChEMBL |
6.8 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(C3CC3)cc2)cc1 |
| E3 Binder |
CHEMBL583465 |
ChEMBL |
6.7 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(Cl)cc2)cc1 |
| E3 Binder |
CHEMBL571952 |
ChEMBL |
6.62 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)CC2c2ccc(OC(C)C)cc2)cc1 |
| E3 Binder |
CHEMBL569184 |
ChEMBL |
6.48 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)C[C@@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL569185 |
ChEMBL |
6.32 |
— |
— |
COc1ccc(CCN2C(=O)N(NS(C)(=O)=O)C[C@H]2c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL384095 |
ChEMBL |
6.59 |
— |
— |
COc1ccc(CNC(=O)NCC(c2ccccc2)C(C(=O)N(C(C)C)C(C)C)c2cccnc2)cc1 |
| E3 Binder |
CHEMBL583047 |
ChEMBL |
6.28 |
— |
— |
COc1ccc([C@H]2CN(NS(C)(=O)=O)C(=O)N2CCc2ccc(OC(F)(F)F)cc2)cc1 |
| E3 Binder |
CHEMBL2440387 |
ChEMBL |
6.29 |
— |
— |
COc1ccc2c(c1)c(/C=N/NS(=O)(=O)c1ccc(C)cc1)cn2CC(=O)Nc1ccc(Cl)cc1 |
| E3 Binder |
CHEMBL3785621 |
ChEMBL |
6.1 |
— |
— |
COc1ccc2c(c1C)C(=O)N(Cc1ccccc1-c1ccccc1)C2C(=O)NC(C)(C)C |
| E3 Binder |
CHEMBL4095750 |
ChEMBL |
7.39 |
— |
— |
COc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL2332448 |
ChEMBL |
7.06 |
— |
— |
COc1cccc(-n2ncnc2C2=C(C)Nc3cc(C(F)(F)F)nn3[C@@H]2c2ccc(Cl)c(Cl)c2)n1 |
| E3 Binder |
CHEMBL466019 |
ChEMBL |
6.8 |
— |
— |
COc1cccc(C(=O)Nc2ccc3c(c2)[C@@H](NS(=O)(=O)c2ccc(C(C)(C)C)cc2)[C@H](O)CC3)c1 |
| E3 Binder |
CHEMBL512964 |
ChEMBL |
6.37 |
— |
— |
COc1cccc(C(=O)Nc2ccc3c(c2)[C@@H](NS(=O)(=O)c2ccc(C(C)C)cc2)[C@H](O)CC3)c1 |
| E3 Binder |
CHEMBL3356074 |
ChEMBL |
7.47 |
— |
— |
COc1cccc2c1C(NCC(C)(C)c1ccccc1)=NC2=O |
| E3 Binder |
CHEMBL3622360 |
ChEMBL |
7.28 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](NC(=O)OC(C)C)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622361 |
ChEMBL |
7.55 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](NC(=O)OCC(F)(F)F)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3623053 |
ChEMBL |
7.33 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](Nc3ncccn3)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622346 |
ChEMBL |
7.47 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](O)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622349 |
ChEMBL |
6.77 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](OC(=O)NC3CC3)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622350 |
ChEMBL |
7.05 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](OC(=O)NCCC(F)(F)F)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622355 |
ChEMBL |
7.52 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](OC(=O)Nc3ccc(N(C)C)cc3)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3622351 |
ChEMBL |
7.04 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](OC(=O)Nc3nnc(C4CC4)s3)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3623054 |
ChEMBL |
7.5 |
— |
— |
COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](n3cnnn3)CC1)=NS2(=O)=O |
| E3 Binder |
CHEMBL3356070 |
ChEMBL |
6.7 |
— |
— |
COc1cccc2c1c(NCC(C)(C)c1ccccc1)nn2C |
| E3 Binder |
CHEMBL3298226 |
ChEMBL |
7.66 |
— |
— |
COc1cccc2ccnc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298227 |
ChEMBL |
7.14 |
— |
— |
COc1cccc2nc(Cl)nc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298228 |
ChEMBL |
7.64 |
— |
— |
COc1cccc2nc(O)nc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298225 |
ChEMBL |
6.93 |
— |
— |
COc1cccc2ncnc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298229 |
ChEMBL |
6.71 |
— |
— |
COc1cccc2oc(=O)nc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298147 |
ChEMBL |
6.73 |
— |
— |
COc1cccc2onc(N(C)CC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3298140 |
ChEMBL |
7.37 |
— |
— |
COc1cccc2onc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL3356073 |
ChEMBL |
7.62 |
— |
— |
COc1cccc2snc(NCC(C)(C)c3ccccc3)c12 |
| E3 Binder |
CHEMBL2332456 |
ChEMBL |
6.94 |
— |
— |
COc1ccccc1-n1ncnc1C1=C(C)Nc2ccnn2[C@@H]1c1ccc(Cl)c(Cl)c1 |
| E3 Binder |
CHEMBL4449766 |
ChEMBL |
6.92 |
— |
— |
COc1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1 |
| E3 Binder |
CHEMBL4061436 |
ChEMBL |
7.0 |
— |
— |
COc1ncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1 |
| E3 Binder |
CHEMBL4105373 |
ChEMBL |
6.24 |
— |
— |
CS(=O)(=O)Nc1cccc(-c2cc(F)ccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4065169 |
ChEMBL |
8.05 |
— |
— |
CS(=O)(=O)Nc1cccc([C@H](c2ccc(F)cc2)C(c2cccnc2)c2cccnc2)n1 |
| E3 Binder |
CHEMBL144107 |
ChEMBL |
6.0 |
— |
— |
C[C@@H](CC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1 |
| E3 Binder |
CHEMBL144174 |
ChEMBL |
6.52 |
— |
— |
C[C@H](CC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1 |
| E3 Binder |
CHEMBL148356 |
ChEMBL |
6.4 |
— |
— |
C[C@H](OC(=O)NCc1ccccc1-c1cccnc1C(=O)NCC1CC1)c1ccccc1 |
| E3 Binder |
CHEMBL4072707 |
ChEMBL |
6.86 |
— |
— |
Cc1cc(F)ccc1-c1ccccc1C(C#N)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL217291 |
ChEMBL |
6.62 |
— |
— |
Cc1ccc(CNC(=O)NCC(c2ccccc2)C(C(=O)N(C(C)C)C(C)C)c2cccnc2)cc1 |
| E3 Binder |
CHEMBL2440384 |
ChEMBL |
6.6 |
— |
— |
Cc1ccc(S(=O)(=O)N/N=C/c2cn(CC(=O)Nc3ccc(F)cc3F)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL2440398 |
ChEMBL |
6.09 |
— |
— |
Cc1ccc(S(=O)(=O)N/N=C/c2cn(CC(=O)Nc3ccccc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL2440383 |
ChEMBL |
6.13 |
— |
— |
Cc1ccc(S(=O)(=O)N/N=C/c2cn(CC(=O)Nc3ccccc3Cl)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL228441 |
ChEMBL |
6.4 |
— |
— |
Cc1ccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)cc1 |
| E3 Binder |
CHEMBL319310 |
ChEMBL |
6.3 |
— |
— |
Cc1ccc(S(=O)(=O)Nc2ccccc2C(=O)N(Cc2ccccc2)Cc2cc[nH]n2)cc1 |
| E3 Binder |
CHEMBL316302 |
ChEMBL |
6.16 |
— |
— |
Cc1ccc(S(=O)(=O)Nc2ccccc2C(=O)N(Cc2ccccc2)Cc2cccnc2)cc1 |
| E3 Binder |
CHEMBL95368 |
ChEMBL |
6.16 |
— |
— |
Cc1ccc(S(=O)(=O)Nc2ccccc2C(=O)N(Cc2ccccc2)Cc2nccn2C)cc1 |
| E3 Binder |
CHEMBL384780 |
ChEMBL |
6.6 |
— |
— |
Cc1cccc(CNC(=O)NCC(c2ccccc2)C(C(=O)N(C(C)C)C(C)C)c2cccnc2)c1 |
| E3 Binder |
CHEMBL147039 |
ChEMBL |
6.0 |
— |
— |
Cc1cccc(CNC(=O)OCc2ccccc2)c1-c1c(C)cccc1C(=O)NCCC(C)C |
| E3 Binder |
CHEMBL148210 |
ChEMBL |
6.16 |
— |
— |
Cc1cccc(CNC(=O)OCc2ccccc2)c1-c1c(C)cccc1C(=O)NCCc1ccccn1 |
| E3 Binder |
CHEMBL228491 |
ChEMBL |
6.47 |
— |
— |
Cc1cccc(S(=O)(=O)N[C@@H]2c3cc(C(=O)NCCc4ccccc4)ccc3OC(C)(C)[C@H]2O)c1 |
| E3 Binder |
CHEMBL3731891 |
ChEMBL |
6.6 |
— |
— |
Cc1ccccc1CN(CCCOc1ccc2c(c1)N(C)C(=O)C(C)(C)C(=O)N2C)CCc1cccnc1.Cl.Cl |
| E3 Binder |
CHEMBL4576889 |
ChEMBL |
7.05 |
— |
— |
Cc1noc(C)c1-c1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1 |
| E3 Binder |
CHEMBL4062996 |
ChEMBL |
7.52 |
— |
— |
Clc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4085436 |
ChEMBL |
7.64 |
— |
— |
Clc1ccccc1-c1ncccc1CC(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4105245 |
ChEMBL |
7.58 |
— |
— |
Clc1ccccc1-c1ncccc1CC(c1cccnc1)c1cccnc1Cl |
| E3 Binder |
CHEMBL4483629 |
ChEMBL |
7.16 |
— |
— |
Clc1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1 |
| E3 Binder |
CHEMBL3893861 |
ChEMBL |
6.52 |
— |
— |
Cn1c(=O)c(OCCCN(CCc2cccnc2)Cc2ccncc2)cc2ccccc21 |
| E3 Binder |
CHEMBL3937958 |
ChEMBL |
6.09 |
— |
— |
Cn1c(=O)ccc2cc(OCCCCCN(CCCc3ccccc3)Cc3cccnc3)ccc21 |
| E3 Binder |
CHEMBL3904810 |
ChEMBL |
6.22 |
— |
— |
Cn1c(=O)ccc2cc(OCCCCCN(CCCc3ccccc3)c3cccnc3)ccc21 |
| E3 Binder |
CHEMBL3975620 |
ChEMBL |
6.29 |
— |
— |
Cn1c(=O)ccc2cc(OCCCCCN(Cc3cccnc3)Cc3cccnc3)ccc21 |
| E3 Binder |
CHEMBL4075394 |
ChEMBL |
7.48 |
— |
— |
FC(F)(F)Oc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4441178 |
ChEMBL |
6.82 |
— |
— |
FC(F)(F)c1ccc(-c2cccc3nc(-c4cncnc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4100098 |
ChEMBL |
7.08 |
— |
— |
FC(F)(F)c1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4521058 |
ChEMBL |
7.1 |
— |
— |
FC(F)(F)c1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1 |
| E3 Binder |
CHEMBL4450583 |
ChEMBL |
6.6 |
— |
— |
Fc1ccc(-c2cccc3nc(-c4cncnc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4437080 |
ChEMBL |
6.89 |
— |
— |
N#Cc1ccc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1 |
| E3 Binder |
CHEMBL3262836 |
ChEMBL |
6.01 |
— |
— |
N#Cc1ccc(OCCN2CCN(CC(=O)Nc3nccs3)CC2)cc1 |
| E3 Binder |
CHEMBL4068841 |
ChEMBL |
6.87 |
— |
— |
N#Cc1cccc(-c2cc(F)ccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL2312930 |
ChEMBL |
6.27 |
— |
— |
N#Cc1cccc(-c2ncccc2CNP(=O)(c2ccccc2)c2ccccc2)c1 |
| E3 Binder |
CHEMBL4450487 |
ChEMBL |
7.3 |
— |
— |
N#Cc1nc(NCc2ccccn2)c2c(-c3ccccc3)cccc2n1 |
| E3 Binder |
CHEMBL4072025 |
ChEMBL |
7.0 |
— |
— |
NC(=O)c1ccc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1 |
| E3 Binder |
CHEMBL4094440 |
ChEMBL |
7.34 |
— |
— |
NS(=O)(=O)c1cncc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)c1 |
| E3 Binder |
CHEMBL4067665 |
ChEMBL |
7.21 |
— |
— |
Nc1cccc(C(Cc2cccnc2-c2cc(Cl)cc(Cl)c2)c2cccnc2)n1 |
| E3 Binder |
CHEMBL4088894 |
ChEMBL |
7.25 |
— |
— |
Nc1cccc(C(Cc2cccnc2-c2cccc(C(F)(F)F)c2)c2cccnc2)n1 |
| E3 Binder |
CHEMBL4102309 |
ChEMBL |
6.82 |
— |
— |
Nc1cccc(C(c2cccnc2)C(O)c2cccnc2-c2cc(Cl)cc(Cl)c2)n1 |
| E3 Binder |
CHEMBL148159 |
ChEMBL |
6.16 |
— |
— |
O=C(NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)OCc1ccccc1 |
| E3 Binder |
CHEMBL3262802 |
ChEMBL |
6.14 |
— |
— |
O=C(c1cccs1)N1CCN(CCOc2ccc(Cl)cc2)CC1 |
| E3 Binder |
CHEMBL3127411 |
ChEMBL |
6.1 |
— |
— |
O=C1CC[C@@H](CN(Cc2ccc(F)cc2)S(=O)(=O)c2cccc(Cl)c2)N1 |
| E3 Binder |
CHEMBL3957181 |
ChEMBL |
6.03 |
— |
— |
O=C1NCCc2cc(OCCCN(CCc3cccnc3)Cc3ccncc3)ccc21 |
| E3 Binder |
CHEMBL2312931 |
ChEMBL |
7.1 |
— |
— |
O=P(NCc1cccnc1-c1cc(Cl)cc(Cl)c1)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2312929 |
ChEMBL |
6.48 |
— |
— |
O=P(NCc1cccnc1-c1cccc(Cl)c1)(c1ccccc1)c1ccccc1 |
| E3 Binder |
CHEMBL2312926 |
ChEMBL |
7.0 |
— |
— |
O=P(c1ccccc1)(c1ccccc1)C(c1ccccc1)c1cccnc1 |
| E3 Binder |
CHEMBL2312927 |
ChEMBL |
6.85 |
— |
— |
O=P(c1ccccc1)(c1ccccc1)C(c1cccnc1)N1CCCCC1 |
| E3 Binder |
CHEMBL2312925 |
ChEMBL |
6.75 |
— |
— |
O=P(c1ccccc1)(c1ccccc1)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL2313226 |
ChEMBL |
6.28 |
— |
— |
O=P(c1ccccc1)(c1ccccc1)N(Cc1ccccn1)c1cccnc1 |
| E3 Binder |
CHEMBL4082779 |
ChEMBL |
7.1 |
— |
— |
O=S(=O)(c1cccc(Nc2nc(-c3cncnc3)nc3cccc(-c4ccccc4)c23)c1)N1CCOCC1 |
| E3 Binder |
CHEMBL4084636 |
ChEMBL |
6.68 |
— |
— |
O=S(=O)(c1cccc(Nc2nc(Cl)nc3cccc(-c4ccccc4)c23)c1)N1CCOCC1 |
| E3 Binder |
CHEMBL4094177 |
ChEMBL |
7.08 |
— |
— |
OC(Cc1cccnc1-c1cc(Cl)cc(Cl)c1)(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4084347 |
ChEMBL |
6.71 |
— |
— |
OC(Cc1cccnc1-c1cccc(C(F)(F)F)c1)(c1cccnc1F)c1cccnc1F |
| E3 Binder |
CHEMBL1091863 |
ChEMBL |
6.69 |
— |
— |
OC(c1ccccc1)(c1ccccc1)C(c1ccccc1)N1CCOCC1 |
| E3 Binder |
CHEMBL1089159 |
ChEMBL |
6.55 |
— |
— |
OC(c1cccnc1)(c1cccnc1)C(c1ccccc1)N1CCCC1 |
| E3 Binder |
CHEMBL1090160 |
ChEMBL |
6.69 |
— |
— |
OC(c1cccnc1)(c1cccnc1)C(c1ccccc1)N1CCCCC1 |
| E3 Binder |
CHEMBL1091163 |
ChEMBL |
6.29 |
— |
— |
OC(c1cccnc1)(c1cccnc1)C(c1ccccc1)N1CCCOCC1 |
| E3 Binder |
CHEMBL1090794 |
ChEMBL |
6.59 |
— |
— |
OC(c1cccnc1)(c1cccnc1)C(c1ccccc1)N1CCOCC1 |
| E3 Binder |
CHEMBL4074029 |
ChEMBL |
6.63 |
— |
— |
OC(c1cccnc1-c1cc(Cl)cc(Cl)c1)C(c1cccnc1)c1ccccn1 |
| E3 Binder |
CHEMBL4089812 |
ChEMBL |
6.55 |
— |
— |
OC(c1cccnc1-c1cccc(Cl)c1)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4094570 |
ChEMBL |
6.56 |
— |
— |
OC(c1cccnc1-c1cccc(Cl)c1)C(c1cccnc1)c1ncco1 |
| E3 Binder |
CHEMBL4097545 |
ChEMBL |
6.96 |
— |
— |
OC(c1cccnc1-c1cccc(Cl)c1Cl)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4061731 |
ChEMBL |
6.77 |
— |
— |
OC(c1cccnc1-c1ccccc1Cl)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4104525 |
ChEMBL |
7.96 |
— |
— |
O[C@@H](c1cccnc1-c1cc(Cl)cc(Cl)c1)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4076764 |
ChEMBL |
6.54 |
— |
— |
O[C@@H](c1cccnc1-c1cccc(C(F)(F)F)c1)C(c1cccnc1)c1cccnc1 |
| E3 Binder |
CHEMBL4081790 |
ChEMBL |
6.96 |
— |
— |
Oc1ccc(-c2nc(NCc3ccccn3)c3c(-c4ccccc4)cccc3n2)cn1 |
| E3 Binder |
CHEMBL4099807 |
ChEMBL |
7.22 |
— |
— |
c1ccc(-c2cccc3nc(-c4cccnc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4521294 |
ChEMBL |
7.4 |
— |
— |
c1ccc(-c2cccc3nc(-c4ccncc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4443183 |
ChEMBL |
6.8 |
— |
— |
c1ccc(-c2cccc3nc(-c4cn[nH]c4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4097255 |
ChEMBL |
7.05 |
— |
— |
c1ccc(-c2cccc3nc(-c4cncnc4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4532101 |
ChEMBL |
7.3 |
— |
— |
c1ccc(-c2cccc3nc(-c4cncs4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL4590051 |
ChEMBL |
6.77 |
— |
— |
c1ccc(-c2cccc3nc(C4CC4)nc(NCc4ccccn4)c23)cc1 |
| E3 Binder |
CHEMBL2152524 |
ChEMBL |
6.52 |
— |
— |
c1ccc([C@@H]([C@H](c2ccccc2)N2CCCC2)N2CCCC2)cc1 |
| E3 Binder |
CHEMBL2152522 |
ChEMBL |
6.7 |
— |
— |
c1ccc([C@@H]([C@H](c2ccccc2)N2CCCCC2)N2CCCCC2)cc1 |
| E3 Binder |
CHEMBL2152525 |
ChEMBL |
6.22 |
— |
— |
c1ccc([C@H]([C@@H](c2ccccc2)N2CCCC2)N2CCCC2)cc1 |
| E3 Binder |
CHEMBL2152523 |
ChEMBL |
6.7 |
— |
— |
c1ccc([C@H]([C@@H](c2ccccc2)N2CCCCC2)N2CCCCC2)cc1 |
| E3 Binder |
CHEMBL4097667 |
ChEMBL |
7.19 |
— |
— |
c1cncc(-c2ccccc2CC(c2cccnc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4087512 |
ChEMBL |
6.35 |
— |
— |
c1cncc(C(Cc2ccccc2-c2ccncc2)c2cccnc2)c1 |
| E3 Binder |
CHEMBL4079636 |
ChEMBL |
6.88 |
— |
— |
c1cncc(C(Cc2ccccc2-c2cncc3ccccc23)c2cccnc2)c1 |