KCNA4

Details:

UniProt Entry: P22459
Gene: KCNA4
Class: Other E3 Components
Family: Adaptor
Protein length: 653
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P22459
MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRAAA AAAVAAATAA VEGSGGSGGG
SHHHHQSRGA CTSHDPQSSR GSRRRRRQRS EKKKAHYRQS SFPHCSDLMP SGSEEKILRE
LSEEEEDEEE EEEEEEEGRF YYSEDDHGDE CSYTDLLPQD EGGGGYSSVR YSDCCERVVI
NVSGLRFETQ MKTLAQFPET LLGDPEKRTQ YFDPLRNEYF FDRNRPSFDA ILYYYQSGGR
LKRPVNVPFD IFTEEVKFYQ LGEEALLKFR EDEGFVREEE DRALPENEFK KQIWLLFEYP
ESSSPARGIA IVSVLVILIS IVIFCLETLP EFRDDRDLVM ALSAGGHGGL LNDTSAPHLE
NSGHTIFNDP FFIVETVCIV WFSFEFVVRC FACPSQALFF KNIMNIIDIV SILPYFITLG
TDLAQQQGGG NGQQQQAMSF AILRIIRLVR VFRIFKLSRH SKGLQILGHT LRASMRELGL
LIFFLFIGVI LFSSAVYFAE ADEPTTHFQS IPDAFWWAVV TMTTVGYGDM KPITVGGKIV
GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TENEEQTQLT QNAVSCPYLP SNLLKKFRSS
TSSSLGDKSE YLEMEEGVKE SLCAKEEKCQ GKGDDSETDK NNCSNAKAVE TDV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	73	Domain	Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain	IPR012897	PF07941
1	75	Homologous_superfamily	Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain superfamily	IPR037065	G3DSA:1.20.5.600
1	13	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
15	21	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
23	37	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
38	48	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
51	60	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
112	126	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
123	277	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
176	272	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
176	276	Domain	BTB/POZ domain	IPR000210	SM00225
178	266	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
205	216	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
218	228	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
219	229	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
262	273	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
278	460	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
297	313	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
310	570	Domain	Ion transport domain	IPR005821	PF00520
320	331	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
357	369	Family	Potassium channel, voltage dependent, Kv1.4	IPR020467	PR01511
453	461	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
477	491	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
548	559	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IBA	GO_REF:0000033
GO:0099505	regulation of presynaptic membrane potential	Biological Process	IEA	GO_REF:0000108
GO:0016020	membrane	Cellular Component	IBA	GO_REF:0000033
GO:0030424	axon	Cellular Component	IBA	GO_REF:0000033
GO:0043194	axon initial segment	Cellular Component	IEA	GO_REF:0000107
GO:0043197	dendritic spine	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000120
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IBA	GO_REF:0000033
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:11937501
GO:0030955	potassium ion binding	Molecular Function	IEA	GO_REF:0000002
GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Molecular Function	IEA	GO_REF:0000107

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL444449	ChEMBL	7.12	—	—	O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
E3 Binder	CHEMBL3906400	ChEMBL	6.3	—	—	O=c1ccc2c(OCCCOc3ccccc3)c3ccoc3cc2o1

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