TNAP3

>P21580
MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF
REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL
VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP
MARSGLQYNS LEEIHIFVLC NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA
QECYRYPIVL GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE
KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ HEYKKWQENS
EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT QPLCHECSER RQKNQNKLPK
LNSKPGPEGL PGMALGASRG EAYEPLAWNP EESTGGPHSA PPTAPSPFLF SETTAMKCRS
PGCPFTLNVQ HNGFCERCHN ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF
KRTTAEASSS LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD
RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR FQNTIPCLGR
ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ RRDVPRTTQS TSRPKCARAS
CKNILACRSE ELCMECQHPN QRMGPGAHRG EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN
ECFQFKQMYG

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
92	263	Domain	OTU domain	IPR003323	PS50802
98	257	Domain	OTU domain	IPR003323	PF02338
381	416	Domain	Zinc finger, A20-type	IPR002653	PS51036
384	409	Domain	Zinc finger, A20-type	IPR002653	SM00259
386	407	Domain	Zinc finger, A20-type	IPR002653	PF01754
472	507	Domain	Zinc finger, A20-type	IPR002653	PS51036
475	500	Domain	Zinc finger, A20-type	IPR002653	SM00259
476	500	Domain	Zinc finger, A20-type	IPR002653	PF01754
518	541	Domain	Zinc finger, A20-type	IPR002653	SM00259
601	636	Domain	Zinc finger, A20-type	IPR002653	PS51036
604	629	Domain	Zinc finger, A20-type	IPR002653	SM00259
651	686	Domain	Zinc finger, A20-type	IPR002653	PS51036
654	679	Domain	Zinc finger, A20-type	IPR002653	SM00259
655	678	Domain	Zinc finger, A20-type	IPR002653	PF01754
713	738	Domain	Zinc finger, A20-type	IPR002653	SM00259
756	790	Domain	Zinc finger, A20-type	IPR002653	PS51036
759	784	Domain	Zinc finger, A20-type	IPR002653	SM00259
760	784	Domain	Zinc finger, A20-type	IPR002653	PF01754

GO term	Name	Ontology	Evidence	Reference
GO:0006508	proteolysis	Biological Process	IEA	GO_REF:0000043
GO:0016579	protein deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0002237	response to molecule of bacterial origin	Biological Process	IEA	GO_REF:0000117
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000117
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0006954	inflammatory response	Biological Process	IEA	GO_REF:0000043
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process	IEA	GO_REF:0000117
GO:0039532	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000117
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0070536	protein K63-linked deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:1901701	cellular response to oxygen-containing compound	Biological Process	IEA	GO_REF:0000117
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0072666	establishment of protein localization to vacuole	Biological Process	IEA	GO_REF:0000107
GO:0001922	B-1 B cell homeostasis	Biological Process	ISS	GO_REF:0000024
GO:0002634	regulation of germinal center formation	Biological Process	ISS	GO_REF:0000024
GO:0002677	negative regulation of chronic inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0007010	cytoskeleton organization	Biological Process	IBA	GO_REF:0000033
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	TAS	Reactome:R-HSA-5357905
GO:0016477	cell migration	Biological Process	IBA	GO_REF:0000033
GO:0030177	positive regulation of Wnt signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IDA	PMID:20392859
GO:0032495	response to muramyl dipeptide	Biological Process	IEA	GO_REF:0000107
GO:0032703	negative regulation of interleukin-2 production	Biological Process	IMP	PMID:18223652
GO:0032715	negative regulation of interleukin-6 production	Biological Process	ISS	GO_REF:0000024
GO:0032720	negative regulation of tumor necrosis factor production	Biological Process	ISS	GO_REF:0000024
GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	Biological Process	NAS	PMID:15142865
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	Biological Process	IDA	PMID:15474016
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Biological Process	NAS	PMID:15142865
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0035871	protein K11-linked deubiquitination	Biological Process	IDA	PMID:23827681
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-168638
GO:0045779	negative regulation of bone resorption	Biological Process	NAS	PMID:21127049
GO:0045824	negative regulation of innate immune response	Biological Process	ISS	GO_REF:0000024
GO:0048662	negative regulation of smooth muscle cell proliferation	Biological Process	IDA	PMID:16816117
GO:0050691	regulation of defense response to virus by host	Biological Process	NAS	PMID:15142865
GO:0050728	negative regulation of inflammatory response	Biological Process	ISS	GO_REF:0000024
GO:0050869	negative regulation of B cell activation	Biological Process	ISS	GO_REF:0000024
GO:0061043	regulation of vascular wound healing	Biological Process	NAS	PMID:16816117
GO:0070301	cellular response to hydrogen peroxide	Biological Process	ISS	GO_REF:0000024
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:15258597
GO:0071108	protein K48-linked deubiquitination	Biological Process	IDA	PMID:23827681
GO:0071222	cellular response to lipopolysaccharide	Biological Process	IDA	PMID:19912257
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0072573	tolerance induction to lipopolysaccharide	Biological Process	IMP	PMID:21220427
GO:0090291	negative regulation of osteoclast proliferation	Biological Process	NAS	PMID:21127049
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Biological Process	IDA	PMID:12167698
GO:2000347	positive regulation of hepatocyte proliferation	Biological Process	IEA	GO_REF:0000107
GO:2000349	negative regulation of CD40 signaling pathway	Biological Process	IMP	PMID:12885753
GO:2000352	negative regulation of endothelial cell apoptotic process	Biological Process	IDA	PMID:12885753
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5357845
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:20458337
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0003824	catalytic activity	Molecular Function	IEA	GO_REF:0000117
GO:0004843	cysteine-type deubiquitinase activity	Molecular Function	IEA	GO_REF:0000003
GO:0008233	peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0002020	protease binding	Molecular Function	IPI	PMID:18223652
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15258597
GO:0005515	protein binding	Molecular Function	IPI	PMID:11463333
GO:0019900	kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0043130	ubiquitin binding	Molecular Function	IPI	PMID:19285159
GO:0061578	K63-linked deubiquitinase activity	Molecular Function	EXP	PMID:14748687
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P21580	TNAP3	Yes	Yes	Yes	No	25416956, 32296183, 11389905, 31515488, 25502805, 30561431	EBI-7864741	E3-specific