KCNA6

Details:

UniProt Entry: P17658
Gene: KCNA6
Class: Other E3 Components
Family: Adaptor
Protein length: 529
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P17658
MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS
VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP
GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV
TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	14	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
16	29	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
26	139	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
32	44	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
41	137	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
41	170	Domain	Potassium voltage-gated channel subfamily A member 6, BTB/POZ domain	IPR046988	cd18407
41	141	Domain	BTB/POZ domain	IPR000210	SM00225
44	132	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
55	66	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
70	81	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
83	93	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
84	94	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
127	138	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
136	148	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
145	358	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
164	180	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
177	468	Domain	Ion transport domain	IPR005821	PF00520
187	198	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
221	234	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
236	247	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
249	260	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
351	359	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
375	389	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
446	457	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
474	488	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513
501	516	Family	Potassium voltage-gated channel subfamily A member 6	IPR004053	PR01513

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	ISS	GO_REF:0000024
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000107
GO:0043679	axon terminus	Cellular Component	IEA	GO_REF:0000107
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0034705	potassium channel complex	Cellular Component	ISS	GO_REF:0000024
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IBA	GO_REF:0000033
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:28514442

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL444449	ChEMBL	6.89	—	—	O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1

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