KCNA2

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
32	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
33	133	Domain	BTB/POZ domain	IPR000210	SM00225
33	130	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
35	125	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
62	73	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
75	85	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
76	86	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
119	130	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
133	310	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
153	169	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
163	420	Domain	Ion transport domain	IPR005821	PF00520
176	187	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
195	209	Family	Potassium channel, voltage dependent, Kv1.2	IPR004049	PR01509
211	223	Family	Potassium channel, voltage dependent, Kv1.2	IPR004049	PR01509
276	287	Family	Potassium channel, voltage dependent, Kv1.2	IPR004049	PR01509
303	311	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
327	341	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
398	409	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
426	443	Family	Potassium channel, voltage dependent, Kv1.2	IPR004049	PR01509
462	475	Family	Potassium channel, voltage dependent, Kv1.2	IPR004049	PR01509

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0021633	optic nerve structural organization	Biological Process	IEA	GO_REF:0000107
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0014059	regulation of dopamine secretion	Biological Process	ISS	GO_REF:0000024
GO:0019228	neuronal action potential	Biological Process	ISS	GO_REF:0000024
GO:0019233	sensory perception of pain	Biological Process	ISS	GO_REF:0000024
GO:0021554	optic nerve development	Biological Process	IEA	GO_REF:0000107
GO:0021987	cerebral cortex development	Biological Process	IEA	GO_REF:0000107
GO:0022038	corpus callosum development	Biological Process	IEA	GO_REF:0000107
GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	Biological Process	IEA	GO_REF:0000107
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0060078	regulation of postsynaptic membrane potential	Biological Process	IEA	GO_REF:0000108
GO:0097623	potassium ion export across plasma membrane	Biological Process	IEA	GO_REF:0000107
GO:0099505	regulation of presynaptic membrane potential	Biological Process	IEA	GO_REF:0000108
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0043005	neuron projection	Cellular Component	IEA	GO_REF:0000043
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000044
GO:0030425	dendrite	Cellular Component	IBA	GO_REF:0000033
GO:0043194	axon initial segment	Cellular Component	IEA	GO_REF:0000107
GO:0043679	axon terminus	Cellular Component	IBA	GO_REF:0000033
GO:0044224	juxtaparanode region of axon	Cellular Component	IBA	GO_REF:0000033
GO:0044305	calyx of Held	Cellular Component	IEA	GO_REF:0000107
GO:0045211	postsynaptic membrane	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0030027	lamellipodium	Cellular Component	ISS	GO_REF:0000024
GO:0030424	axon	Cellular Component	ISS	GO_REF:0000024
GO:0031258	lamellipodium membrane	Cellular Component	IEA	GO_REF:0000044
GO:0032809	neuronal cell body membrane	Cellular Component	ISS	GO_REF:0000024
GO:0033010	paranodal junction	Cellular Component	IEA	GO_REF:0000044
GO:0042734	presynaptic membrane	Cellular Component	IEA	GO_REF:0000120
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043204	perikaryon	Cellular Component	ISS	GO_REF:0000024
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000043
GO:0034705	potassium channel complex	Cellular Component	IEA	GO_REF:0000107
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0022843	voltage-gated monoatomic cation channel activity	Molecular Function	IEA	GO_REF:0000117
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:21357749
GO:0015271	outward rectifier potassium channel activity	Molecular Function	IEA	GO_REF:0000107
GO:0019894	kinesin binding	Molecular Function	IEA	GO_REF:0000107
GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Molecular Function	IEA	GO_REF:0000107
GO:1905030	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	Molecular Function	IEA	GO_REF:0000107

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL444449	ChEMBL	6.6	—	—	O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1

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KCNA2

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾