RAG1

Details:

UniProt Entry: P15918
Gene: RAG1
Class: RING
Family: RING9
Protein length: 1043
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>P15918
MAASFPPTLG LSSAPDEIQH PHIKFSEWKF KLFRVRSFEK TPEEAQKEKK DSFEGKPSLE
QSPAVLDKAD GQKPVPTQPL LKAHPKFSKK FHDNEKARGK AIHQANLRHL CRICGNSFRA
DEHNRRYPVH GPVDGKTLGL LRKKEKRATS WPDLIAKVFR IDVKADVDSI HPTEFCHNCW
SIMHRKFSSA PCEVYFPRNV TMEWHPHTPS CDICNTARRG LKRKSLQPNL QLSKKLKTVL
DQARQARQHK RRAQARISSK DVMKKIANCS KIHLSTKLLA VDFPEHFVKS ISCQICEHIL
ADPVETNCKH VFCRVCILRC LKVMGSYCPS CRYPCFPTDL ESPVKSFLSV LNSLMVKCPA
KECNEEVSLE KYNHHISSHK ESKEIFVHIN KGGRPRQHLL SLTRRAQKHR LRELKLQVKA
FADKEEGGDV KSVCMTLFLL ALRARNEHRQ ADELEAIMQG KGSGLQPAVC LAIRVNTFLS
CSQYHKMYRT VKAITGRQIF QPLHALRNAE KVLLPGYHHF EWQPPLKNVS SSTDVGIIDG
LSGLSSSVDD YPVDTIAKRF RYDSALVSAL MDMEEDILEG MRSQDLDDYL NGPFTVVVKE
SCDGMGDVSE KHGSGPVVPE KAVRFSFTIM KITIAHSSQN VKVFEEAKPN SELCCKPLCL
MLADESDHET LTAILSPLIA EREAMKSSEL MLELGGILRT FKFIFRGTGY DEKLVREVEG
LEASGSVYIC TLCDATRLEA SQNLVFHSIT RSHAENLERY EVWRSNPYHE SVEELRDRVK
GVSAKPFIET VPSIDALHCD IGNAAEFYKI FQLEIGEVYK NPNASKEERK RWQATLDKHL
RKKMNLKPIM RMNGNFARKL MTKETVDAVC ELIPSEERHE ALRELMDLYL KMKPVWRSSC
PAKECPESLC QYSFNSQRFA ELLSTKFKYR YEGKITNYFH KTLAHVPEII ERDGSIGAWA
SEGNESGNKL FRRFRKMNAR QSKCYEMEDV LKHHWLYTSK YLQKFMNAHN ALKTSGFTMN
PQASLGDPLG IEDSLESQDS MEF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	1043	Family	V(D)J recombination-activating protein 1	IPR024627	PTHR11539
12	291	Domain	RAG1 importin-binding	IPR035714	PF12560
268	353	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
293	331	Domain	Zinc finger, RING-type	IPR001841	SM00184
293	332	Domain	Zinc finger, RING-type	IPR001841	PS50089
308	317	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
354	383	Domain	V(D)J recombination-activating protein 1, Zinc finger	IPR019485	PF10426
354	383	Domain	V(D)J recombination-activating protein 1, Zinc finger	IPR019485	PS51765
354	383	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
386	1021	Family	V(D)J recombination-activating protein 1	IPR024627	PF12940
392	459	Domain	RAG nonamer-binding domain	IPR023336	PS51487

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006310	DNA recombination	Biological Process	IEA	GO_REF:0000043
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006955	immune response	Biological Process	IEA	GO_REF:0000117
GO:0030183	B cell differentiation	Biological Process	IEA	GO_REF:0000104
GO:0033077	T cell differentiation in thymus	Biological Process	IEA	GO_REF:0000104
GO:0033151	V(D)J recombination	Biological Process	IEA	GO_REF:0000120
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000107
GO:0043029	T cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0045580	regulation of T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0048538	thymus development	Biological Process	IEA	GO_REF:0000107
GO:0070233	negative regulation of T cell apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0070244	negative regulation of thymocyte apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0002331	pre-B cell allelic exclusion	Biological Process	ISS	GO_REF:0000024
GO:0008542	visual learning	Biological Process	IEA	GO_REF:0000120
GO:0045582	positive regulation of T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:2000822	regulation of behavioral fear response	Biological Process	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0097519	DNA recombinase complex	Cellular Component	IBA	GO_REF:0000033
GO:1905347	endodeoxyribonuclease complex	Cellular Component	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003824	catalytic activity	Molecular Function	IEA	GO_REF:0000043
GO:0004518	nuclease activity	Molecular Function	IEA	GO_REF:0000043
GO:0004519	endonuclease activity	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000104
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042393	histone binding	Molecular Function	IEA	GO_REF:0000104
GO:0042803	protein homodimerization activity	Molecular Function	IEA	GO_REF:0000104
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:1990238	double-stranded DNA endonuclease activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:17474147
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾


C9JYI4	C9JYI4	Yes	No	No	No	—	No	E3-specific
P52292	IMA1	Yes	No	No	No	—	No	E3-specific
Q16695	H31T	Yes	Yes	No	No	—	No	E3-specific
P52294	IMA5	Yes	Yes	Yes	No	8052633	EBI-8633004	E3-specific
P15918	RAG1	Yes	Yes	No	No	—	No	E3-specific

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