TRI27

Details:

UniProt Entry: P14373
Gene: TRIM27
Class: RING
Family: RING5
Protein length: 513
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>P14373
MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF
PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR
SREHRGHSVL PLEEAVEGFK EQIQNQLDHL KRVKDLKKRR RAQGEQARAE LLSLTQMERE
KIVWEFEQLY HSLKEHEYRL LARLEELDLA IYNSINGAIT QFSCNISHLS SLIAQLEEKQ
QQPTRELLQD IGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS
DMEKIQELRE AQLYSVDVTL DPDTAYPSLI LSDNLRQVRY SYLQQDLPDN PERFNLFPCV
LGSPCFIAGR HYWEVEVGDK AKWTIGVCED SVCRKGGVTS APQNGFWAVS LWYGKEYWAL
TSPMTALPLR TPLQRVGIFL DYDAGEVSFY NVTERCHTFT FSHATFCGPV RPYFSLSYSG
GKSAAPLIIC PMSGIDGFSG HVGNHGHSME TSP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	85	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
91	132	Domain	B-box-type zinc finger	IPR000315	PS50119
91	132	Domain	B-box-type zinc finger	IPR000315	SM00336
92	132	Domain	B-box-type zinc finger	IPR000315	PF00643
104	121	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406
123	137	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406
298	492	Domain	B30.2/SPRY domain	IPR001870	PS50188
308	492	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
309	502	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
314	331	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
315	491	Domain	TRIM27, PRY/SPRY domain	IPR035791	cd15814
315	367	Domain	SPRY-associated	IPR006574	SM00589
318	366	Domain	SPRY-associated	IPR006574	PF13765
331	348	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
353	377	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
368	493	Domain	SPRY domain	IPR003877	SM00449
370	477	Domain	SPRY domain	IPR003877	PF00622
383	396	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
427	451	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
458	476	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0010507	negative regulation of autophagy	Biological Process	IDA	PMID:35670107
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:35670107
GO:0032481	positive regulation of type I interferon production	Biological Process	IDA	PMID:14703513
GO:0045814	negative regulation of gene expression, epigenetic	Biological Process	IDA	PMID:10976108
GO:0051127	positive regulation of actin nucleation	Biological Process	IEA	GO_REF:0000107
GO:0007283	spermatogenesis	Biological Process	TAS	PMID:3380101
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0016925	protein sumoylation	Biological Process	TAS	Reactome:R-HSA-3108232
GO:0032480	negative regulation of type I interferon production	Biological Process	IDA	PMID:26358190
GO:0032897	negative regulation of viral transcription	Biological Process	IBA	GO_REF:0000033
GO:0034314	Arp2/3 complex-mediated actin nucleation	Biological Process	IDA	PMID:23452853
GO:0042147	retrograde transport, endosome to Golgi	Biological Process	IDA	PMID:23452853
GO:0044790	suppression of viral release by host	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0070534	protein K63-linked ubiquitination	Biological Process	IMP	PMID:23452853
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0030904	retromer complex	Cellular Component	IDA	PMID:23452853
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8850997
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:0031965	nuclear membrane	Cellular Component	IDA	PMID:10976108
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003676	nucleic acid binding	Molecular Function	TAS	PMID:3380101
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IMP	PMID:23452853
GO:0005515	protein binding	Molecular Function	IPI	PMID:10504338
GO:0019789	SUMO transferase activity	Molecular Function	EXP	PMID:12393906
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:17156811
GO:0141039	phosphatidylinositol 3-kinase inhibitor activity	Molecular Function	IDA	PMID:22128329

Enzyme–Substrate Interactions ▾


Q15561	TEAD4	Yes	No	Yes	No	26871637, 32296183	EBI-24361783	E3-specific
O00750	P3C2B	Yes	Yes	Yes	No	22128329	EBI-5667785	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q15561	TEAD4	Yes	No	Yes	No	26871637, 32296183	EBI-24361783	E3-specific
O00750	P3C2B	Yes	Yes	Yes	No	22128329	EBI-5667785	E3-specific