TZAP

Details:

UniProt Entry: P10074
Gene: ZBTB48
Class: RING
Family: RING6
Protein length: 688
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 3b84, 5yj3

Protein Sequence ▾

>P10074
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV
GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP
AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD
GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF
LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR
RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT
ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL
NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV
ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH
DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL
CAEESFTGPG VLEPSLIITA AVPEDCDT

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
4	120	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
7	114	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
16	115	Domain	BTB/POZ domain	IPR000210	PF00651
26	89	Domain	BTB/POZ domain	IPR000210	PS50097
26	119	Domain	BTB/POZ domain	IPR000210	SM00225
290	338	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
291	318	Domain	Zinc finger C2H2-type	IPR013087	PS50157
291	313	Domain	Zinc finger C2H2-type	IPR013087	SM00355
293	313	Domain	Zinc finger C2H2-type	IPR013087	PS00028
319	338	Domain	Zinc finger C2H2-type	IPR013087	PF00096
319	339	Domain	Zinc finger C2H2-type	IPR013087	SM00355
319	346	Domain	Zinc finger C2H2-type	IPR013087	PS50157
346	396	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
350	372	Domain	Zinc finger C2H2-type	IPR013087	SM00355
350	377	Domain	Zinc finger C2H2-type	IPR013087	PS50157
350	372	Domain	Zinc finger C2H2-type	IPR013087	PF00096
352	372	Domain	Zinc finger C2H2-type	IPR013087	PS00028
378	401	Domain	Zinc finger C2H2-type	IPR013087	SM00355
378	406	Domain	Zinc finger C2H2-type	IPR013087	PS50157
380	401	Domain	Zinc finger C2H2-type	IPR013087	PS00028
387	443	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
407	430	Domain	Zinc finger C2H2-type	IPR013087	SM00355
407	435	Domain	Zinc finger C2H2-type	IPR013087	PS50157
409	430	Domain	Zinc finger C2H2-type	IPR013087	PS00028
436	459	Domain	Zinc finger C2H2-type	IPR013087	SM00355
436	464	Domain	Zinc finger C2H2-type	IPR013087	PS50157
449	502	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
465	487	Domain	Zinc finger C2H2-type	IPR013087	SM00355
465	487	Domain	Zinc finger C2H2-type	IPR013087	PF00096
465	492	Domain	Zinc finger C2H2-type	IPR013087	PS50157
467	487	Domain	Zinc finger C2H2-type	IPR013087	PS00028
487	539	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
493	520	Domain	Zinc finger C2H2-type	IPR013087	PS50157
493	515	Domain	Zinc finger C2H2-type	IPR013087	PF00096
493	515	Domain	Zinc finger C2H2-type	IPR013087	SM00355
495	515	Domain	Zinc finger C2H2-type	IPR013087	PS00028
521	544	Domain	Zinc finger C2H2-type	IPR013087	SM00355
521	549	Domain	Zinc finger C2H2-type	IPR013087	PS50157
523	544	Domain	Zinc finger C2H2-type	IPR013087	PS00028
548	600	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
550	572	Domain	Zinc finger C2H2-type	IPR013087	SM00355
550	577	Domain	Zinc finger C2H2-type	IPR013087	PS50157
551	572	Domain	Zinc finger C2H2-type	IPR013087	PF00096
552	572	Domain	Zinc finger C2H2-type	IPR013087	PS00028
578	600	Domain	Zinc finger C2H2-type	IPR013087	SM00355
578	605	Domain	Zinc finger C2H2-type	IPR013087	PS50157
578	600	Domain	Zinc finger C2H2-type	IPR013087	PF00096
580	600	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0010833	telomere maintenance via telomere lengthening	Biological Process	IMP	PMID:28082411
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0051252	regulation of RNA metabolic process	Biological Process	IMP	PMID:39300486
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000781	chromosome, telomeric region	Cellular Component	IEA	GO_REF:0000120
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000976	transcription cis-regulatory region binding	Molecular Function	IDA	PMID:28500257
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003691	double-stranded telomeric DNA binding	Molecular Function	IDA	PMID:28082411
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IBA	GO_REF:0000033
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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