FBSP1

Details:

UniProt Entry: P0C2W1
Gene: FBXO45
Class: Other E3 Components
Family: Receptor
Protein length: 286
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P0C2W1
MAAPAPGAGA ASGGAGCSGG GAGAGAGSGS GAAGAGGRLP SRVLELVFSY LELSELRSCA
LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKIRAF QHAFSTNDCS
RNVYIKKNGF TLHRNPIAQS TDGARTKIGF SEGRHAWEVW WEGPLGTVAV IGIATKRAPM
QCQGYVALLG SDDQSWGWNL VDNNLLHNGE VNGSFPQCNN APKYQIGERI RVILDMEDKT
LAFERGYEFL GVAFRGLPKV CLYPAVSAVY GNTEVTLVYL GKPLDG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
33	82	Domain	F-box domain	IPR001810	PS50181
38	87	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
38	84	Domain	F-box domain	IPR001810	PF12937
39	82	Domain	F-box domain	IPR001810	SM00256
79	283	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
92	284	Domain	B30.2/SPRY domain	IPR001870	PS50188
110	284	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
112	286	Domain	Fbxo45, SPRY domain	IPR035784	cd12907
152	284	Domain	SPRY domain	IPR003877	SM00449
154	277	Domain	SPRY domain	IPR003877	PF00622

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0001764	neuron migration	Biological Process	IEA	GO_REF:0000107
GO:0021799	cerebral cortex radially oriented cell migration	Biological Process	IEA	GO_REF:0000107
GO:0021800	cerebral cortex tangential migration	Biological Process	IEA	GO_REF:0000107
GO:0021957	corticospinal tract morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0021960	anterior commissure morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0060384	innervation	Biological Process	IEA	GO_REF:0000107
GO:0060386	synapse assembly involved in innervation	Biological Process	IEA	GO_REF:0000107
GO:0061564	axon development	Biological Process	ISS	PMID:30304512
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:29997255
GO:0006974	DNA damage response	Biological Process	IDA	PMID:19581926
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000043
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:2000300	regulation of synaptic vesicle exocytosis	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IC	PMID:29997255
GO:0045202	synapse	Cellular Component	IBA	GO_REF:0000033
GO:0098793	presynapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099523	presynaptic cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0099524	postsynaptic cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0005576	extracellular region	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000043
GO:0014069	postsynaptic density	Cellular Component	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0042734	presynaptic membrane	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043226	organelle	Cellular Component	IEA	GO_REF:0000117
GO:0045211	postsynaptic membrane	Cellular Component	IEA	GO_REF:0000120
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:19581926

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