NSD2

Details:

UniProt Entry: O96028

Gene: NSD2

Class: RING

Family: RING10

Protein length: 1365

Database confidence: 0.375

InterPro: InterPro Entry

Mode of Action: Unclassified

AlphaFold Model: Link

PDB Structures: 5lsu, 5vc8, 6ue6, 6xcg, 7cro, 7e8d, 7lmt, 7mdn, 7vln

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
220	285	Domain	PWWP domain	IPR000313	SM00293
222	286	Domain	PWWP domain	IPR000313	PS50812
223	331	Domain	PWWP domain	IPR000313	PF00855
438	507	Homologous_superfamily	High mobility group box domain superfamily	IPR036910	SSF47095
452	522	Domain	High mobility group box domain	IPR009071	SM00398
453	502	Domain	High mobility group box domain	IPR009071	PS50118
457	506	Domain	High mobility group box domain	IPR009071	PF00505
458	507	Homologous_superfamily	High mobility group box domain superfamily	IPR036910	G3DSA:1.10.30.10
654	715	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
659	711	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
667	713	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
669	711	Domain	Zinc finger, PHD-type	IPR001965	SM00249
670	710	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
670	710	Domain	Zinc finger, RING-type	IPR001841	SM00184
716	778	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
716	763	Domain	Zinc finger, PHD-type	IPR001965	SM00249
717	762	Domain	Zinc finger, RING-type	IPR001841	SM00184
717	763	Domain	Zinc finger, RING-type	IPR001841	PS50089
821	887	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
825	874	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
831	875	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
833	873	Domain	Zinc finger, PHD-type	IPR001965	SM00249
834	872	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
878	940	Domain	PWWP domain	IPR000313	SM00293
880	942	Domain	PWWP domain	IPR000313	PS50812
882	969	Domain	PWWP domain	IPR000313	PF00855
977	1203	Homologous_superfamily	SET domain superfamily	IPR046341	G3DSA:2.170.270.10
982	1193	Homologous_superfamily	SET domain superfamily	IPR046341	SSF82199
1011	1061	Domain	AWS domain	IPR006560	PS51215
1011	1062	Domain	AWS domain	IPR006560	SM00570
1022	1060	Domain	AWS domain	IPR006560	PF17907
1063	1186	Domain	SET domain	IPR001214	SM00317
1063	1180	Domain	SET domain	IPR001214	PS50280
1074	1180	Domain	SET domain	IPR001214	PF00856
1187	1203	Domain	Post-SET domain	IPR003616	SM00508
1187	1203	Domain	Post-SET domain	IPR003616	PS50868
1216	1283	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1225	1331	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1241	1284	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1282	1327	Domain	NSD, Cys-His rich domain	IPR041306	PF17982

Protein functions ▾

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0032259	methylation	Biological Process	IEA	GO_REF:0000043
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0003149	membranous septum morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0003289	atrial septum primum morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0003290	atrial septum secundum morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0048298	positive regulation of isotype switching to IgA isotypes	Biological Process	IEA	GO_REF:0000107
GO:0060348	bone development	Biological Process	IEA	GO_REF:0000107
GO:0070201	regulation of establishment of protein localization	Biological Process	IEA	GO_REF:0000107
GO:2001032	regulation of double-strand break repair via nonhomologous end joining	Biological Process	IEA	GO_REF:0000107
GO:0006302	double-strand break repair	Biological Process	TAS	Reactome:R-HSA-5693606
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0008168	methyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046975	histone H3K36 methyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:19481544
GO:0042054	histone methyltransferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0042799	histone H4K20 methyltransferase activity	Molecular Function	TAS	Reactome:R-HSA-5682965
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0140938	histone H3 methyltransferase activity	Molecular Function	TAS	Reactome:R-HSA-4827383
GO:0140954	histone H3K36 dimethyltransferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0140955	histone H3K36 trimethyltransferase activity	Molecular Function	IEA	GO_REF:0000107

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL2000196	ChEMBL	6.26	—	—	CC(=O)N(/N=C1\Sc2ccccc2C1=O)c1ccccc1C
E3 Binder	CHEMBL4876215	ChEMBL	6.05	—	—	CC(=O)N1CCC(N2C[C@H]3C[C@@H](C2)c2ccc(-c4ccccc4CN4CCOCC4)c(=O)n2C3)CC1
E3 Binder	CHEMBL1698802	ChEMBL	6.12	—	—	CC(N=C1C=C(O)c2cccnc2C1=O)C(O)c1ccccc1
E3 Binder	CHEMBL1734152	ChEMBL	6.06	—	—	CC1COCC(C)N1C1=C(Cl)C(=O)c2ccccc2C1=O
E3 Binder	CHEMBL1399113	ChEMBL	6.46	—	—	CC1NC(=O)NC1CCCCCC(=O)Nc1ccc(F)c(Cl)c1
E3 Binder	CHEMBL1311154	ChEMBL	6.95	—	—	CC1NC(=O)NC1CCCCCC(=O)Nc1ccc(F)cc1
E3 Binder	CHEMBL1698845	ChEMBL	6.0	—	—	CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(N(CC)CC)cc2)cc1.[Cl-]
E3 Binder	CHEMBL5195926	ChEMBL	6.16	—	—	CCNCc1cc(C)c(-c2ncn(C)c2-c2ccc(C#N)c3ccccc23)c(C)c1
E3 Binder	CHEMBL1733422	ChEMBL	6.58	—	—	CCOC(=O)c1c2c(n(Cc3ccccc3)c1C)C(=O)C(=O)c1ccccc1-2
E3 Binder	CHEMBL284328	ChEMBL	6.53	—	—	CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc21.[Br-]
E3 Binder	CHEMBL3190880	ChEMBL	6.58	—	—	CCc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)cc1
E3 Binder	CHEMBL599924	ChEMBL	7.06	—	—	CCn1nc(/C=C/c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2
E3 Binder	CHEMBL1737002	ChEMBL	6.13	—	—	CN(C)c1ccc2cc(S(=O)(=O)O)cc(O)c2c1
E3 Binder	CHEMBL5193618	ChEMBL	6.05	—	—	CN1C(=O)CCC(N2C(=O)c3cccc(NCC(=O)NCCCOc4ccc(NC(=O)c5ccc(CN(C(=O)c6ccc7c(c6)OCC(=O)N7)C6CC6)cc5)nc4)c3C2=O)C1=O
E3 Binder	CHEMBL1163377	ChEMBL	6.97	—	—	CN1CCN(C2=C(Cl)C(=O)c3ccccc3C2=O)CC1
E3 Binder	CHEMBL1432707	ChEMBL	6.39	—	—	COC(=O)c1cc(C)nc2c1C(=O)C(=O)C=C2N1CCOCC1
E3 Binder	CHEMBL3197637	ChEMBL	6.25	—	—	COC(=O)c1ccccc1NC1=C/C(=N\S(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2C1=O
E3 Binder	CHEMBL1702473	ChEMBL	6.21	—	—	COC1=C(N)C(=O)c2nc(C)ccc2C1=O
E3 Binder	CHEMBL1381627	ChEMBL	6.18	—	—	COc1cc(-c2nnc(SCc3cc(=O)oc4cc(O)c(O)cc34)o2)cc(OC)c1OC
E3 Binder	CHEMBL1598762	ChEMBL	6.38	—	—	COc1cc(Br)c(C(=O)c2nccc3cc(OC)c(OC)cc23)cc1OC
E3 Binder	CHEMBL1327934	ChEMBL	6.33	—	—	COc1cc(NC(C)CCCN)c2ncccc2c1Oc1ccccc1.O=C(O)CCC(=O)O
E3 Binder	CHEMBL1571034	ChEMBL	6.55	—	—	COc1cc(OC)c(-c2c3cc(O)c(=O)cc-3oc3cc(O)c(O)cc23)cc1OC
E3 Binder	CHEMBL5172030	ChEMBL	6.28	—	—	Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL5197903	ChEMBL	6.24	—	—	Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)cc1
E3 Binder	CHEMBL5186268	ChEMBL	6.96	—	—	Cc1cc(CN2CCC(N)CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL5181192	ChEMBL	6.28	—	—	Cc1cc(CN2CCC(O)C2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL5170326	ChEMBL	6.19	—	—	Cc1cc(CNC(C)(C)C)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL5204960	ChEMBL	6.37	—	—	Cc1cc(CNC2CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL5170310	ChEMBL	6.21	—	—	Cc1cc(CNCCN)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12
E3 Binder	CHEMBL1343539	ChEMBL	6.45	—	—	Cc1ccc(NC(=O)CCCCCC2NC(=O)NC2C)cc1
E3 Binder	CHEMBL1969046	ChEMBL	6.59	—	—	Cc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)c(C)c1
E3 Binder	CHEMBL1982305	ChEMBL	6.38	—	—	Cc1ccc(S(=O)(=O)/N=C2\C=C(Nc3cccc(C(=O)O)c3)C(=O)c3ccccc32)cc1
E3 Binder	CHEMBL1698715	ChEMBL	6.28	—	—	Cc1ccc2c(c1C)-c1c(ccc(C)c1C)C(=O)C2=O
E3 Binder	CHEMBL1999630	ChEMBL	6.93	—	—	Cc1ccccc1NC1=C/C(=N\S(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2C1=O
E3 Binder	CHEMBL1735482	ChEMBL	6.79	—	—	NC1=C(Br)C(=O)c2ncccc2C1=O
E3 Binder	CHEMBL1734083	ChEMBL	6.84	—	—	NC1=C(Cl)C(=O)c2ccc(S(N)(=O)=O)cc2C1=O
E3 Binder	CHEMBL156174	ChEMBL	6.26	—	—	NC1=CC(=O)C(=O)c2cccnc21
E3 Binder	CHEMBL417727	ChEMBL	6.56	—	—	Nc1ccc2c(c1)C(=O)C(=O)c1ccccc1-2
E3 Binder	CHEMBL1982107	ChEMBL	6.13	—	—	O=C(CSc1nc2ccccc2o1)N/N=C/c1ccc(O)c(O)c1
E3 Binder	CHEMBL1424694	ChEMBL	6.14	—	—	O=C(O)c1cccc(-n2cccc2/C=C2/NC(=O)N(c3ccc(Cl)cc3)C2=O)c1
E3 Binder	CHEMBL235504	ChEMBL	6.01	—	—	O=C1C(=O)c2cccnc2-c2ncccc21
E3 Binder	CHEMBL1699845	ChEMBL	6.22	—	—	O=C1C(Cl)=C(Oc2ccccc2)C(=O)c2ccccc21
E3 Binder	CHEMBL5200945	ChEMBL	7.04	V01	—	O=C1COc2cc(C(=O)N(Cc3ccc(C(=O)Nc4ccncn4)cc3)C3CC3)ccc2N1
E3 Binder	CHEMBL607979	ChEMBL	6.39	—	—	O=C1Nc2ccccc2/C1=N/N=C/c1ccc(O)c(O)c1
E3 Binder	CHEMBL1542926	ChEMBL	6.18	—	—	O=[N+]([O-])c1ccc(-[n+]2nc(-c3ccccc3)nn2-c2ccccc2)cc1.[Br-]
E3 Binder	CHEMBL66953	ChEMBL	6.27	TIY	—	O=c1c(O)cccc2cc(O)c(O)c(O)c12
E3 Binder	CHEMBL210208	ChEMBL	6.84	—	—	O=c1ccc2c(-c3ccccc3S(=O)(=O)O)c3ccc(O)c(O)c3oc-2c1O
E3 Binder	CHEMBL1966224	ChEMBL	6.2	—	—	Oc1ccc(/C=N/N=C(c2ccccc2)c2ccccc2)c(O)c1O

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