HERC2

>O95714
MPSESFCLAA QARLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ESTQNGELPP
RKDDSVEPSG TKKEDLNDKE KKDEEETPAP IYRAKSILDS WVWGKQPDVN ELKECLSVLV
KEQQALAVQS ATTTLSALRL KQRLVILERY FIALNRTVFQ ENVKVKWKSS GISLPPVDKK
SSRPAGKGVE GLARVGSRAA LSFAFAFLRR AWRSGEDADL CSELLQESLD ALRALPEASL
FDESTVSSVW LEVVERATRF LRSVVTGDVH GTPATKGPGS IPLQDQHLAL AILLELAVQR
GTLSQMLSAI LLLLQLWDSG AQETDNERSA QGTSAPLLPL LQRFQSIICR KDAPHSEGDM
HLLSGPLSPN ESFLRYLTLP QDNELAIDLR QTAVVVMAHL DRLATPCMPP LCSSPTSHKG
SLQEVIGWGL IGWKYYANVI GPIQCEGLAN LGVTQIACAE KRFLILSRNG RVYTQAYNSD
TLAPQLVQGL ASRNIVKIAA HSDGHHYLAL AATGEVYSWG CGDGGRLGHG DTVPLEEPKV
ISAFSGKQAG KHVVHIACGS TYSAAITAEG ELYTWGRGNY GRLGHGSSED EAIPMLVAGL
KGLKVIDVAC GSGDAQTLAV TENGQVWSWG DGDYGKLGRG GSDGCKTPKL IEKLQDLDVV
KVRCGSQFSI ALTKDGQVYS WGKGDNQRLG HGTEEHVRYP KLLEGLQGKK VIDVAAGSTH
CLALTEDSEV HSWGSNDQCQ HFDTLRVTKP EPAALPGLDT KHIVGIACGP AQSFAWSSCS
EWSIGLRVPF VVDICSMTFE QLDLLLRQVS EGMDGSADWP PPQEKECVAV ATLNLLRLQL
HAAISHQVDP EFLGLGLGSI LLNSLKQTVV TLASSAGVLS TVQSAAQAVL QSGWSVLLPT
AEERARALSA LLPCAVSGNE VNISPGRRFM IDLLVGSLMA DGGLESALHA AITAEIQDIE
AKKEAQKEKE IDEQEANAST FHRSRTPLDK DLINTGICES SGKQCLPLVQ LIQQLLRNIA
SQTVARLKDV ARRISSCLDF EQHSRERSAS LDLLLRFQRL LISKLYPGES IGQTSDISSP
ELMGVGSLLK KYTALLCTHI GDILPVAASI ASTSWRHFAE VAYIVEGDFT GVLLPELVVS
IVLLLSKNAG LMQEAGAVPL LGGLLEHLDR FNHLAPGKER DDHEELAWPG IMESFFTGQN
CRNNEEVTLI RKADLENHNK DGGFWTVIDG KVYDIKDFQT QSLTGNSILA QFAGEDPVVA
LEAALQFEDT RESMHAFCVG QYLEPDQEIV TIPDLGSLSS PLIDTERNLG LLLGLHASYL
AMSTPLSPVE IECAKWLQSS IFSGGLQTSQ IHYSYNEEKD EDHCSSPGGT PASKSRLCSH
RRALGDHSQA FLQAIADNNI QDHNVKDFLC QIERYCRQCH LTTPIMFPPE HPVEEVGRLL
LCCLLKHEDL GHVALSLVHA GALGIEQVKH RTLPKSVVDV CRVVYQAKCS LIKTHQEQGR
SYKEVCAPVI ERLRFLFNEL RPAVCNDLSI MSKFKLLSSL PRWRRIAQKI IRERRKKRVP
KKPESTDDEE KIGNEESDLE EACILPHSPI NVDKRPIAIK SPKDKWQPLL STVTGVHKYK
WLKQNVQGLY PQSPLLSTIA EFALKEEPVD VEKMRKCLLK QLERAEVRLE GIDTILKLAS
KNFLLPSVQY AMFCGWQRLI PEGIDIGEPL TDCLKDVDLI PPFNRMLLEV TFGKLYAWAV
QNIRNVLMDA SAKFKELGIQ PVPLQTITNE NPSGPSLGTI PQARFLLVML SMLTLQHGAN
NLDLLLNSGM LALTQTALRL IGPSCDNVEE DMNASAQGAS ATVLEETRKE TAPVQLPVSG
PELAAMMKIG TRVMRGVDWK WGDQDGPPPG LGRVIGELGE DGWIRVQWDT GSTNSYRMGK
EGKYDLKLAE LPAAAQPSAE DSDTEDDSEA EQTERNIHPT AMMFTSTINL LQTLCLSAGV
HAEIMQSEAT KTLCGLLRML VESGTTDKTS SPNRLVYREQ HRSWCTLGFV RSIALTPQVC
GALSSPQWIT LLMKVVEGHA PFTATSLQRQ ILAVHLLQAV LPSWDKTERA RDMKCLVEKL
FDFLGSLLTT CSSDVPLLRE STLRRRRVRP QASLTATHSS TLAEEVVALL RTLHSLTQWN
GLINKYINSQ LRSITHSFVG RPSEGAQLED YFPDSENPEV GGLMAVLAVI GGIDGRLRLG
GQVMHDEFGE GTVTRITPKG KITVQFSDMR TCRVCPLNQL KPLPAVAFNV NNLPFTEPML
SVWAQLVNLA GSKLEKHKIK KSTKQAFAGQ VDLDLLRCQQ LKLYILKAGR ALLSHQDKLR
QILSQPAVQE TGTVHTDDGA VVSPDLGDMS PEGPQPPMIL LQQLLASATQ PSPVKAIFDK
QELEAAALAV CQCLAVESTH PSSPGFEDCS SSEATTPVAV QHIRPARVKR RKQSPVPALP
IVVQLMEMGF SRRNIEFALK SLTGASGNAS SLPGVEALVG WLLDHSDIQV TELSDADTVS
DEYSDEEVVE DVDDAAYSMS TGAVVTESQT YKKRADFLSN DDYAVYVREN IQVGMMVRCC
RAYEEVCEGD VGKVIKLDRD GLHDLNVQCD WQQKGGTYWV RYIHVELIGY PPPSSSSHIK
IGDKVRVKAS VTTPKYKWGS VTHQSVGVVK AFSANGKDII VDFPQQSHWT GLLSEMELVP
SIHPGVTCDG CQMFPINGSR FKCRNCDDFD FCETCFKTKK HNTRHTFGRI NEPGQSAVFC
GRSGKQLKRC HSSQPGMLLD SWSRMVKSLN VSSSVNQASR LIDGSEPCWQ SSGSQGKHWI
RLEIFPDVLV HRLKMIVDPA DSSYMPSLVV VSGGNSLNNL IELKTININP SDTTVPLLND
CTEYHRYIEI AIKQCRSSGI DCKIHGLILL GRIRAEEEDL AAVPFLASDN EEEEDEKGNS
GSLIRKKAAG LESAATIRTK VFVWGLNDKD QLGGLKGSKI KVPSFSETLS ALNVVQVAGG
SKSLFAVTVE GKVYACGEAT NGRLGLGISS GTVPIPRQIT ALSSYVVKKV AVHSGGRHAT
ALTVDGKVFS WGEGDDGKLG HFSRMNCDKP RLIEALKTKR IRDIACGSSH SAALTSSGEL
YTWGLGEYGR LGHGDNTTQL KPKMVKVLLG HRVIQVACGS RDAQTLALTD EGLVFSWGDG
DFGKLGRGGS EGCNIPQNIE RLNGQGVCQI ECGAQFSLAL TKSGVVWTWG KGDYFRLGHG
SDVHVRKPQV VEGLRGKKIV HVAVGALHCL AVTDSGQVYA WGDNDHGQQG NGTTTVNRKP
TLVQGLEGQK ITRVACGSSH SVAWTTVDVA TPSVHEPVLF QTARDPLGAS YLGVPSDADS
SAASNKISGA SNSKPNRPSL AKILLSLDGN LAKQQALSHI LTALQIMYAR DAVVGALMPA
AMIAPVECPS FSSAAPSDAS AMASPMNGEE CMLAVDIEDR LSPNPWQEKR EIVSSEDAVT
PSAVTPSAPS ASARPFIPVT DDLGAASIIA ETMTKTKEDV ESQNKAAGPE PQALDEFTSL
LIADDTRVVV DLLKLSVCSR AGDRGRDVLS AVLSGMGTAY PQVADMLLEL CVTELEDVAT
DSQSGRLSSQ PVVVESSHPY TDDTSTSGTV KIPGAEGLRV EFDRQCSTER RHDPLTVMDG
VNRIVSVRSG REWSDWSSEL RIPGDELKWK FISDGSVNGW GWRFTVYPIM PAAGPKELLS
DRCVLSCPSM DLVTCLLDFR LNLASNRSIV PRLAASLAAC AQLSALAASH RMWALQRLRK
LLTTEFGQSI NINRLLGEND GETRALSFTG SALAALVKGL PEALQRQFEY EDPIVRGGKQ
LLHSPFFKVL VALACDLELD TLPCCAETHK WAWFRRYCMA SRVAVALDKR TPLPRLFLDE
VAKKIRELMA DSENMDVLHE SHDIFKREQD EQLVQWMNRR PDDWTLSAGG SGTIYGWGHN
HRGQLGGIEG AKVKVPTPCE ALATLRPVQL IGGEQTLFAV TADGKLYATG YGAGGRLGIG
GTESVSTPTL LESIQHVFIK KVAVNSGGKH CLALSSEGEV YSWGEAEDGK LGHGNRSPCD
RPRVIESLRG IEVVDVAAGG AHSACVTAAG DLYTWGKGRY GRLGHSDSED QLKPKLVEAL
QGHRVVDIAC GSGDAQTLCL TDDDTVWSWG DGDYGKLGRG GSDGCKVPMK IDSLTGLGVV
KVECGSQFSV ALTKSGAVYT WGKGDYHRLG HGSDDHVRRP RQVQGLQGKK VIAIATGSLH
CVCCTEDGEV YTWGDNDEGQ LGDGTTNAIQ RPRLVAALQG KKVNRVACGS AHTLAWSTSK
PASAGKLPAQ VPMEYNHLQE IPIIALRNRL LLLHHLSELF CPCIPMFDLE GSLDETGLGP
SVGFDTLRGI LISQGKEAAF RKVVQATMVR DRQHGPVVEL NRIQVKRSRS KGGLAGPDGT
KSVFGQMCAK MSSFGPDSLL LPHRVWKVKF VGESVDDCGG GYSESIAEIC EELQNGLTPL
LIVTPNGRDE SGANRDCYLL SPAARAPVHS SMFRFLGVLL GIAIRTGSPL SLNLAEPVWK
QLAGMSLTIA DLSEVDKDFI PGLMYIRDNE ATSEEFEAMS LPFTVPSASG QDIQLSSKHT
HITLDNRAEY VRLAINYRLH EFDEQVAAVR EGMARVVPVP LLSLFTGYEL ETMVCGSPDI
PLHLLKSVAT YKGIEPSASL IQWFWEVMES FSNTERSLFL RFVWGRTRLP RTIADFRGRD
FVIQVLDKYN PPDHFLPESY TCFFLLKLPR YSCKQVLEEK LKYAIHFCKS IDTDDYARIA
LTGEPAADDS SDDSDNEDVD SFASDSTQDY LTGH

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
422	778	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
422	790	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
514	569	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
514	566	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
569	612	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
570	621	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
623	672	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
624	675	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
642	683	Repeat	Beta-propeller repeat TECPR	IPR006624	SM00706
675	724	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
676	727	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
1205	1296	Homologous_superfamily	Cytochrome b5-like heme/steroid binding domain superfamily	IPR036400	G3DSA:3.10.120.10
1206	1289	Homologous_superfamily	Cytochrome b5-like heme/steroid binding domain superfamily	IPR036400	SSF55856
1207	1283	Domain	Cytochrome b5-like heme/steroid binding domain	IPR001199	PS50255
1210	1283	Domain	Cytochrome b5-like heme/steroid binding domain	IPR001199	SM01117
1212	1282	Domain	Cytochrome b5-like heme/steroid binding domain	IPR001199	PF00173
1859	1932	Domain	Mib-herc2	IPR010606	PS51416
1863	1929	Homologous_superfamily	Mib/herc2 domain superfamily	IPR037252	SSF159034
1870	1929	Domain	Mib-herc2	IPR010606	PF06701
2550	2631	Homologous_superfamily	Ribosomal protein L2, domain 2	IPR014722	G3DSA:2.30.30.30
2554	2630	Domain	CPH domain	IPR021097	PF11515
2699	2750	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
2702	2746	Domain	Zinc finger, ZZ-type	IPR000433	SM00291
2702	2742	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
2703	2755	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
2706	2750	Domain	HERC2, zinc finger, ZZ-type	IPR041987	cd02344
2708	2735	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
2729	2911	Homologous_superfamily	Galactose-binding-like domain superfamily	IPR008979	SSF49785
2759	2936	Domain	APC10/DOC domain	IPR004939	PS51284
2765	2910	Domain	HERC2, APC10 domain	IPR037976	cd08664
2779	2936	Domain	APC10/DOC domain	IPR004939	SM01337
2803	2870	Domain	APC10/DOC domain	IPR004939	PF03256
2956	3328	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
2958	3326	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
2959	3010	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
2960	2976	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
2977	3018	Repeat	Beta-propeller repeat TECPR	IPR006624	SM00706
3010	3062	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3011	3065	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3065	3114	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3066	3117	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3104	3114	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
3104	3120	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
3117	3160	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3118	3169	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3120	3134	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
3171	3220	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3172	3223	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3213	3231	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
3223	3272	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3224	3275	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3240	3283	Repeat	Beta-propeller repeat TECPR	IPR006624	SM00706
3271	3292	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
3275	3323	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
3276	3327	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3949	4320	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
3952	4003	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3953	4321	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
3970	4010	Repeat	Beta-propeller repeat TECPR	IPR006624	SM00706
4003	4054	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4004	4057	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4057	4106	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4058	4109	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4110	4161	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4110	4152	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4163	4212	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4164	4215	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4182	4223	Repeat	Beta-propeller repeat TECPR	IPR006624	SM00706
4215	4263	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4216	4267	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4267	4315	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4268	4319	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4421	4792	Domain	HECT domain	IPR000569	cd00078
4453	4799	Domain	HECT domain	IPR000569	SM00119
4457	4794	Domain	HECT domain	IPR000569	PS50237
4459	4788	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
4518	4789	Domain	HECT domain	IPR000569	PF00632

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000107
GO:0030182	neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0006886	intracellular protein transport	Biological Process	NAS	PMID:9949213
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-4551724
GO:0005814	centriole	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	NAS	PMID:9949213
GO:0005515	protein binding	Molecular Function	IPI	PMID:20023648
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:22508508
GO:0032183	SUMO binding	Molecular Function	IDA	PMID:22508508
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96JN8	NEUL4	Yes	Yes	No	No	29426014	EBI-16811555	E3-specific
P23025	XPA	Yes	Yes	Yes	No	20304803	EBI-15843635	E3-specific
P63165	SUMO1	Yes	No	No	No	—	No	E3-specific
Q9Y2K6	UBP20	Yes	Yes	Yes	No	29426014, 19615732	EBI-16811652	E3-specific