ARI2

Details:

UniProt Entry: O95376
Gene: ARIH2
Class: RBR
Family: RBR
Protein length: 493
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 7od1, 7oni

Protein Sequence ▾

>O95376
MSVDMNSQGS DSNEEDYDPN CEEEEEEEED DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ
FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA
RVQPNPSKHV PTSHPPHHCA VCMQFVRKEN LLSLACQHQF CRSCWEQHCS VLVKDGVGVG
VSCMAQDCPL RTPEDFVFPL LPNEELREKY RRYLFRDYVE SHYQLQLCPG ADCPMVIRVQ
EPRARRVQCN RCNEVFCFKC RQMYHAPTDC ATIRKWLTKC ADDSETANYI SAHTKDCPKC
NICIEKNGGC NHMQCSKCKH DFCWMCLGDW KTHGSEYYEC SRYKENPDIV NQSQQAQARE
ALKKYLFYFE RWENHNKSLQ LEAQTYQRIH EKIQERVMNN LGTWIDWQYL QNAAKLLAKC
RYTLQYTYPY AYYMESGPRK KLFEYQQAQL EAEIENLSWK VERADSYDRG DLENQMHIAE
QRRRTLLKDF HDT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
90	426	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
135	223	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
135	344	Domain	TRIAD supradomain	IPR044066	PS51873
139	190	Domain	Zinc finger, RING-type	IPR001841	PS50089
139	172	Domain	Zinc finger, RING-type	IPR001841	SM00184
208	270	Domain	IBR domain	IPR002867	SM00647
208	270	Domain	IBR domain	IPR002867	PF01485
278	340	Domain	IBR domain	IPR002867	SM00647
292	333	Domain	IBR domain	IPR002867	PF01485
300	340	Domain	Zinc finger, RING-type	IPR001841	PS50089
300	340	Domain	Zinc finger, RING-type	IPR001841	SM00184
318	327	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
353	470	Domain	Ariadne domain	IPR045840	PF19422

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22190037
GO:0045087	innate immune response	Biological Process	IDA	PMID:22915799
GO:0051607	defense response to virus	Biological Process	IDA	PMID:22915799
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:16118314
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0048588	developmental cell growth	Biological Process	IDA	PMID:19340006
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:19340006
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:16118314
GO:0071425	hematopoietic stem cell proliferation	Biological Process	IDA	PMID:16118314
GO:1903955	positive regulation of protein targeting to mitochondrion	Biological Process	HMP	PMID:24270810
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:24076655
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:16118314
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q15653	IKBB	Yes	Yes	No	No	—	No	E3-specific
Q99684	GFI1	Yes	Yes	No	No	—	No	E3-specific

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q15653	IKBB	Yes	Yes	No	No	—	No	E3-specific
Q99684	GFI1	Yes	Yes	No	No	—	No	E3-specific