ZBT7A

Details:

UniProt Entry: O95365

Gene: ZBTB7A

Class: RING

Family: RING6

Protein length: 584

Database confidence: 0.25

InterPro: InterPro Entry

Mode of Action: Unclassified

AlphaFold Model: Link

PDB Structures: 2if5, 2nn2, 7eyi, 7n5s, 7n5t, 7n5u, 7n5v, 7n5w, 8e3d, 8e3e

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
7	152	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
11	128	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	130	Domain	BTB/POZ domain	IPR000210	PF00651
34	131	Domain	BTB/POZ domain	IPR000210	SM00225
34	101	Domain	BTB/POZ domain	IPR000210	PS50097
382	404	Domain	Zinc finger C2H2-type	IPR013087	SM00355
382	409	Domain	Zinc finger C2H2-type	IPR013087	PS50157
384	404	Domain	Zinc finger C2H2-type	IPR013087	PS00028
396	447	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
410	432	Domain	Zinc finger C2H2-type	IPR013087	PF00096
410	432	Domain	Zinc finger C2H2-type	IPR013087	SM00355
410	437	Domain	Zinc finger C2H2-type	IPR013087	PS50157
412	432	Domain	Zinc finger C2H2-type	IPR013087	PS00028
432	484	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
438	460	Domain	Zinc finger C2H2-type	IPR013087	SM00355
438	465	Domain	Zinc finger C2H2-type	IPR013087	PS50157
438	460	Domain	Zinc finger C2H2-type	IPR013087	PF00096
440	460	Domain	Zinc finger C2H2-type	IPR013087	PS00028
466	486	Domain	Zinc finger C2H2-type	IPR013087	SM00355
466	501	Domain	Zinc finger C2H2-type	IPR013087	PS50157

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Biological Process	IDA	PMID:24514149
GO:0006110	regulation of glycolytic process	Biological Process	IMP	PMID:26455326
GO:0006325	chromatin organization	Biological Process	ISS	GO_REF:0000024
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:26816381
GO:0006351	DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0030183	B cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IMP	PMID:25514493
GO:0034504	protein localization to nucleus	Biological Process	IMP	PMID:15917220
GO:0042981	regulation of apoptotic process	Biological Process	IMP	PMID:24514149
GO:0043249	erythrocyte maturation	Biological Process	ISS	GO_REF:0000024
GO:0045444	fat cell differentiation	Biological Process	IMP	PMID:14701838
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0051090	regulation of DNA-binding transcription factor activity	Biological Process	ISS	GO_REF:0000024
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:15917220
GO:0060766	negative regulation of androgen receptor signaling pathway	Biological Process	IMP	PMID:20812024
GO:0097680	double-strand break repair via classical nonhomologous end joining	Biological Process	ISS	GO_REF:0000024
GO:2000677	regulation of transcription regulatory region DNA binding	Biological Process	IDA	PMID:12004059
GO:0035861	site of double-strand break	Cellular Component	ISS	GO_REF:0000024
GO:0070418	DNA-dependent protein kinase complex	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:15917220
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001222	transcription corepressor binding	Molecular Function	IDA	PMID:20812024
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000107
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:15917220
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0035035	histone acetyltransferase binding	Molecular Function	IEA	GO_REF:0000107
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0046332	SMAD binding	Molecular Function	IDA	PMID:25514493
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0050681	nuclear androgen receptor binding	Molecular Function	IDA	PMID:20812024
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IPI	PMID:12004059
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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