TRI16

Details:

UniProt Entry: O95361
Gene: TRIM16
Class: RING
Family: RING5
Protein length: 564
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7qs3

Protein Sequence ▾

>O95361
MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK LGRETEEQDS
DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT
EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC QDCCQEHSGH TIVSLDAARR DKEAELQCTQ
LDLERKLKLN ENAISRLQAN QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK
EQAALSQANG IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY
VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV VQRKYWTSKP
EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP WEHPYPDLPS RFLHWRQVLS
QQSLYLHRYY FEVEIFGAGT YVGLTCKGID RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY
SDMETPLKAG PFRRLGVYID FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE
NAIRIVDLGE EPEKPAPSLV GTAP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
72	122	Domain	B-box-type zinc finger	IPR000315	SM00336
126	165	Domain	B-box-type zinc finger	IPR000315	SM00336
126	165	Domain	B-box-type zinc finger	IPR000315	PS50119
129	165	Domain	B-box-type zinc finger	IPR000315	PF00643
355	553	Domain	B30.2/SPRY domain	IPR001870	PS50188
356	546	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
365	540	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
371	388	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
372	425	Domain	SPRY-associated	IPR006574	SM00589
375	423	Domain	SPRY-associated	IPR006574	PF13765
411	435	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
426	551	Domain	SPRY domain	IPR003877	SM00449
428	544	Domain	SPRY domain	IPR003877	PF00622
440	453	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
486	510	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000002
GO:0032526	response to retinoic acid	Biological Process	IEP	PMID:16636064
GO:0032731	positive regulation of interleukin-1 beta production	Biological Process	IMP	PMID:16575408
GO:0045618	positive regulation of keratinocyte differentiation	Biological Process	IDA	PMID:11919186
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IDA	PMID:16636064
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	Biological Process	IDA	PMID:16636064
GO:0060416	response to growth hormone	Biological Process	IDA	PMID:11919186
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0016605	PML body	Cellular Component	IDA	PMID:16636064
GO:0003677	DNA binding	Molecular Function	IDA	PMID:16636064
GO:0005515	protein binding	Molecular Function	IPI	PMID:16575408
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019966	interleukin-1 binding	Molecular Function	IPI	PMID:16575408
GO:0032089	NACHT domain binding	Molecular Function	IPI	PMID:16575408
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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