KLHL2

Details:

UniProt Entry: O95198
Gene: KLHL2
Class: Other E3 Components
Family: Adaptor
Protein length: 593
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O95198
METPPLPPAC TKQGHQKPLD SKDDNTEKHC PVTVNPWHMK KAFKVMNELR SQNLLCDVTI
VAEDMEISAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK EVDGWTLRML IDYVYTAEIQ
VTEENVQVLL PAAGLLQLQD VKKTCCEFLE SQLHPVNCLG IRAFADMHAC TDLLNKANTY
AEQHFADVVL SEEFLNLGIE QVCSLISSDK LTISSEEKVF EAVIAWVNHD KDVRQEFMAR
LMEHVRLPLL PREYLVQRVE EEALVKNSSA CKDYLIEAMK YHLLPTEQRI LMKSVRTRLR
TPMNLPKLMV VVGGQAPKAI RSVECYDFKE ERWHQVAELP SRRCRAGMVY MAGLVFAVGG
FNGSLRVRTV DSYDPVKDQW TSVANMRDRR STLGAAVLNG LLYAVGGFDG STGLSSVEAY
NIKSNEWFHV APMNTRRSSV GVGVVGGLLY AVGGYDGASR QCLSTVECYN ATTNEWTYIA
EMSTRRSGAG VGVLNNLLYA VGGHDGPLVR KSVEVYDPTT NAWRQVADMN MCRRNAGVCA
VNGLLYVVGG DDGSCNLASV EYYNPTTDKW TVVSSCMSTG RSYAGVTVID KPL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	593	Family	BTB-kelch protein	IPR017096	PIRSF037037
25	154	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
35	151	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
35	155	Domain	Kelch-like protein 2 , BTB/POZ domain	IPR044072	cd18338
46	152	Domain	BTB/POZ domain	IPR000210	PF00651
56	153	Domain	BTB/POZ domain	IPR000210	SM00225
56	123	Domain	BTB/POZ domain	IPR000210	PS50097
158	260	Domain	BTB/Kelch-associated	IPR011705	SM00875
158	260	Domain	BTB/Kelch-associated	IPR011705	PF07707
292	593	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
308	353	Repeat	Kelch repeat type 1	IPR006652	SM00612
308	587	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
309	340	Repeat	Kelch repeat type 1	IPR006652	PF01344
342	387	Repeat	Kelch repeat type 1	IPR006652	PF01344
354	400	Repeat	Kelch repeat type 1	IPR006652	SM00612
389	434	Repeat	Kelch repeat type 1	IPR006652	PF01344
401	447	Repeat	Kelch repeat type 1	IPR006652	SM00612
436	483	Repeat	Kelch repeat type 1	IPR006652	PF01344
448	496	Repeat	Kelch repeat type 1	IPR006652	SM00612
485	530	Repeat	Kelch repeat type 1	IPR006652	PF01344
497	543	Repeat	Kelch repeat type 1	IPR006652	SM00612
533	576	Repeat	Kelch repeat type 1	IPR006652	PF01344
544	591	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0001726	ruffle	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0015629	actin cytoskeleton	Cellular Component	IDA	PMID:10397770
GO:0030027	lamellipodium	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956

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