UBE4B

Details:

UniProt Entry: O95155
Gene: UBE4B
Class: RING
Family: RING7
Protein length: 1302
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2kre, 3l1x, 3l1z, 5o75

Protein Sequence ▾

>O95155
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIAAAARSPD
RNLLLNTGSN PGTSPMFCSV ASFGASSLSS LYESSPAPTP SFWSSVPVMG PSLASPSRAA
SQLAVPSTPL SPHSAASGTA AGSQPSSPRY RPYTVTHPWA SSGVSILSSS PSPPALASSP
QAVPASSSRQ RPSSTGPPLP PASPSATSRR PSSLRISPSL GASGGASNWD SYSDHFTIET
CKETDMLNYL IECFDRVGIE EKKAPKMCSQ PAVSQLLSNI RSQCISHTAL VLQGSLTQPR
SLQQPSFLVP YMLCRNLPYG FIQELVRTTH QDEEVFKQIF IPILQGLALA AKECSLDSDY
FKYPLMALGE LCETKFGKTH PVCNLVASLR LWLPKSLSPG CGRELQRLSY LGAFFSFSVF
AEDDVKVVEK YFSGPAITLE NTRVVSQSLQ HYLELGRQEL FKILHSILLN GETREAALSY
MAAVVNANMK KAQMQTDDRL VSTDGFMLNF LWVLQQLSTK IKLETVDPTY IFHPRCRITL
PNDETRVNAT MEDVNDWLTE LYGDQPPFSE PKFPTECFFL TLHAHHLSIL PSCRRYIRRL
RAIRELNRTV EDLKNNESQW KDSPLATRHR EMLKRCKTQL KKLVRCKACA DAGLLDESFL
RRCLNFYGLL IQLLLRILDP AYPDITLPLN SDVPKVFAAL PEFYVEDVAE FLFFIVQYSP
QALYEPCTQD IVMFLVVMLC NQNYIRNPYL VAKLVEVMFM TNPAVQPRTQ KFFEMIENHP
LSTKLLVPSL MKFYTDVEHT GATSEFYDKF TIRYHISTIF KSLWQNIAHH GTFMEEFNSG
KQFVRYINML INDTTFLLDE SLESLKRIHE VQEEMKNKEQ WDQLPRDQQQ ARQSQLAQDE
RVSRSYLALA TETVDMFHIL TKQVQKPFLR PELGPRLAAM LNFNLQQLCG PKCRDLKVEN
PEKYGFEPKK LLDQLTDIYL QLDCARFAKA IADDQRSYSK ELFEEVISKM RKAGIKSTIA
IEKFKLLAEK VEEIVAKNAR AEIDYSDAPD EFRDPLMDTL MTDPVRLPSG TIMDRSIILR
HLLNSPTDPF NRQTLTESML EPVPELKEQI QAWMREKQNS DH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
23	1302	Family	Ubiquitin conjugation factor E4	IPR045132	PTHR13931
591	1212	Domain	Ubiquitin conjugation factor E4, core	IPR019474	PF10408
1225	1302	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1227	1300	Domain	U-box domain	IPR003613	PS51698
1228	1299	Domain	U-box domain	IPR003613	PF04564
1231	1293	Domain	U-box domain	IPR003613	SM00504

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000104
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0036503	ERAD pathway	Biological Process	IEA	GO_REF:0000002
GO:0003222	ventricular trabecula myocardium morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0031175	neuron projection development	Biological Process	IEA	GO_REF:0000107
GO:0034976	response to endoplasmic reticulum stress	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:23509263
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0008626	granzyme-mediated apoptotic signaling pathway	Biological Process	IDA	PMID:11802788
GO:0009411	response to UV	Biological Process	IDA	PMID:11802788
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:20414249
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000107
GO:0019899	enzyme binding	Molecular Function	ISS	GO_REF:0000024
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾


Q8IWX7	UN45B	Yes	Yes	No	No	—	No	E3-specific
Q99689	FEZ1	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8IWX7	UN45B	Yes	Yes	No	No	—	No	E3-specific
Q99689	FEZ1	Yes	Yes	No	No	—	No	E3-specific