UBR5

>O95071
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF
LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR TSRPGRTSDS PWFLSGSETL
GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI
PASVIPEELI SQAQVVLQGK SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE
SYLPGEDLMS LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV QSPVSLGEDL
QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP YRNAQNPSLH HPRATFLGLT
NEKIVLLSAN SIRATVATEN NKVATWVDET LSSVASKLEH TAQTYSELQG ERIVSLHCCA
LYTCAQLENS LYWWGVVPFS QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP
LYHAGAVAFS ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ WSLREVVFVE
DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD PSSLLQDCRL LRIDELQVVK
TGGTPKVPDC FQRTPKKLCI PEKTEILAVN VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ
ENNFPTSSIA FLGQNERNVA IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP
ISSLGMGVHS LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN TFAERLSAVE
AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG LGRHEAGASS SDHQDPVSPP
IAPPSWVPDP PAMDPDGDID FILAPAVGSL TTAATGTGQG PSTSTIPGPS TEPSVVESKD
RKANAHFILK LLCDSVVLQP YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA
KAEISSSEKE EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA RLDLLYRLLT
ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE DRNRKTASPE DSDMPDHDLE
PPRFAQLALE RVLQDWNALK SMIMFGSQEN KDPLSASSRI GHLLPEEQVY LNQQSGTIRL
DCFTHCLIVK CTADILLLDT LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS
VEMASSKKKN NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA
STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ SQPVRGRDEE
QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG QHDEHDEDGS DMELDLLAAA
ETESDSESNH SNQDNASGRR SVVTAATAGS EAGASSVPAF FSEDDSQSND SSDSDSSSSQ
SDDIEQETFM LDEPLERTTN SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS
SAGLIYIDPS NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE AQLRYGSALA
SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR ATLLSARQGM MSARGDFLNY
ALSLMRSHND EHSDVLPVLD VCSLKHVAYV FQALIYWIKA MNQQTTLDTP QLERKRTREL
LELGIDNEDS EHENDDDTNQ SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF
EVPLAEAIPL ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT
KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS SLLAEIGLTE
SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF MEDVGAEPGS ILTELGGFEV
KESKFRREME KLRNQQSRDL SLEVDRDRDL LIQQTMRQLN NHFGRRCATT PMAVHRVKVT
FKDEPGEGSG VARSFYTAIA QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER
EREREMRRSS GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII AHGRENGADS
ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD NAPLFYQPGK RGFYTPRPGK
NTEARLNCFR NIGRILGLCL LQNELCPITL NRHVIKVLLG RKVNWHDFAF FDPVMYESLR
QLILASQSSD ADAVFSAMDL AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE
HRMLVVAEQP LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES
GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP SITIRPPDDQ
HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
180	230	Domain	E3 ubiquitin ligase EDD, ubiquitin-associated domain	IPR024725	PF11547
184	230	Domain	E3 ubiquitin ligase EDD, ubiquitin-associated domain	IPR024725	cd14423
329	535	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
361	496	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
1177	1245	Domain	Zinc finger, UBR-type	IPR003126	PS51157
1177	1244	Domain	Zinc finger, UBR-type	IPR003126	SM00396
2247	2792	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
2360	2458	Homologous_superfamily	PABC (PABP) domain	IPR036053	SSF63570
2377	2454	Domain	Polyadenylate-binding protein/Hyperplastic disc protein	IPR002004	PS51309
2389	2452	Domain	Polyadenylate-binding protein/Hyperplastic disc protein	IPR002004	SM00517
2391	2449	Domain	Polyadenylate-binding protein/Hyperplastic disc protein	IPR002004	PF00658
2432	2799	Domain	HECT domain	IPR000569	SM00119
2501	2798	Domain	HECT domain	IPR000569	PF00632
2504	2799	Domain	HECT domain	IPR000569	PS50237

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006979	response to oxidative stress	Biological Process	IDA	PMID:17603038
GO:0010498	proteasomal protein catabolic process	Biological Process	IDA	PMID:34711951
GO:0010628	positive regulation of gene expression	Biological Process	IDA	PMID:18076571
GO:0030520	estrogen receptor signaling pathway	Biological Process	IDA	PMID:15831516
GO:0048384	retinoic acid receptor signaling pathway	Biological Process	IDA	PMID:19917671
GO:0050847	progesterone receptor signaling pathway	Biological Process	IDA	PMID:10757795
GO:0070561	vitamin D receptor signaling pathway	Biological Process	IDA	PMID:9267036
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0033696	heterochromatin boundary formation	Biological Process	IMP	PMID:22884692
GO:0035519	protein K29-linked ubiquitination	Biological Process	IDA	PMID:21118991
GO:0042307	positive regulation of protein import into nucleus	Biological Process	IMP	PMID:21118991
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:28689657
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:21118991
GO:0071629	cytoplasm protein quality control by the ubiquitin-proteasome system	Biological Process	IDA	PMID:29033132
GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	Biological Process	IDA	PMID:37478846
GO:0090263	positive regulation of canonical Wnt signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0140455	cytoplasm protein quality control	Biological Process	IDA	PMID:29033132
GO:0140861	DNA repair-dependent chromatin remodeling	Biological Process	IMP	PMID:22884692
GO:0141198	protein branched polyubiquitination	Biological Process	IDA	PMID:29033132
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0000785	chromatin	Cellular Component	IDA	PMID:37478846
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:18076571
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:18076571
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043130	ubiquitin binding	Molecular Function	IEA	GO_REF:0000002
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:12011095
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O43313	ATMIN	Yes	No	No	No	—	No	E3-specific
Q9BPZ3	PAIP2	Yes	Yes	Yes	No	16601676	EBI-8295718	E3-specific
P52907	CAZA1	Yes	No	No	No	—	No	E3-specific
P35558	PCKGC	Yes	Yes	No	No	—	No	E3-specific
O95071	UBR5	Yes	No	No	No	—	No	E3-specific
Q92547	TOPB1	Yes	Yes	No	No	—	No	E3-specific
O95994	AGR2	Yes	No	No	No	—	No	E3-specific
P50750	CDK9	Yes	Yes	No	No	—	No	E3-specific