TRI37

Details:

UniProt Entry: O94972
Gene: TRIM37
Class: RING
Family: RING9
Protein length: 964
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 3lrq

Protein Sequence ▾

>O94972
MDEQSVESIA EVFRCFICME KLRDARLCPH CSKLCCFSCI RRWLTEQRAQ CPHCRAPLQL
RELVNCRWAE EVTQQLDTLQ LCSLTKHEEN EKDKCENHHE KLSVFCWTCK KCICHQCALW
GGMHGGHTFK PLAEIYEQHV TKVNEEVAKL RRRLMELISL VQEVERNVEA VRNAKDERVR
EIRNAVEMMI ARLDTQLKNK LITLMGQKTS LTQETELLES LLQEVEHQLR SCSKSELISK
SSEILMMFQQ VHRKPMASFV TTPVPPDFTS ELVPSYDSAT FVLENFSTLR QRADPVYSPP
LQVSGLCWRL KVYPDGNGVV RGYYLSVFLE LSAGLPETSK YEYRVEMVHQ SCNDPTKNII
REFASDFEVG ECWGYNRFFR LDLLANEGYL NPQNDTVILR FQVRSPTFFQ KSRDQHWYIT
QLEAAQTSYI QQINNLKERL TIELSRTQKS RDLSPPDNHL SPQNDDALET RAKKSACSDM
LLEGGPTTAS VREAKEDEED EEKIQNEDYH HELSDGDLDL DLVYEDEVNQ LDGSSSSASS
TATSNTEEND IDEETMSGEN DVEYNNMELE EGELMEDAAA AGPAGSSHGY VGSSSRISRR
THLCSAATSS LLDIDPLILI HLLDLKDRSS IENLWGLQPR PPASLLQPTA SYSRKDKDQR
KQQAMWRVPS DLKMLKRLKT QMAEVRCMKT DVKNTLSEIK SSSAASGDMQ TSLFSADQAA
LAACGTENSG RLQDLGMELL AKSSVANCYI RNSTNKKSNS PKPARSSVAG SLSLRRAVDP
GENSRSKGDC QTLSEGSPGS SQSGSRHSSP RALIHGSIGD ILPKTEDRQC KALDSDAVVV
AVFSGLPAVE KRRKMVTLGA NAKGGHLEGL QMTDLENNSE TGELQPVLPE GASAAPEEGM
SSDSDIECDT ENEEQEEHTS VGGFHDSFMV MTQPPDEDTH SSFPDGEQIG PEDLSFNTDE
NSGR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	90	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	55	Domain	Zinc finger, RING-type	IPR001841	PS50089
90	132	Domain	B-box-type zinc finger	IPR000315	SM00336
90	132	Domain	B-box-type zinc finger	IPR000315	PF00643
90	132	Domain	B-box-type zinc finger	IPR000315	PS50119
132	254	Domain	B-box, C-terminal	IPR003649	SM00502
273	406	Domain	TRIM37, MATH domain	IPR037299	cd03773
276	403	Domain	MATH/TRAF domain	IPR002083	PS50144
278	405	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
281	384	Domain	MATH/TRAF domain	IPR002083	SM00061
284	400	Domain	MATH/TRAF domain	IPR002083	PF00917

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016558	protein import into peroxisome matrix	Biological Process	IDA	PMID:28724525
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:25470042
GO:0006513	protein monoubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0045814	negative regulation of gene expression, epigenetic	Biological Process	IEA	GO_REF:0000120
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046600	negative regulation of centriole replication	Biological Process	IMP	PMID:23769972
GO:0050821	protein stabilization	Biological Process	IDA	PMID:28724525
GO:0051865	protein autoubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070842	aggresome assembly	Biological Process	IBA	GO_REF:0000033
GO:0035098	ESC/E(Z) complex	Cellular Component	IDA	PMID:25470042
GO:0005778	peroxisomal membrane	Cellular Component	IBA	GO_REF:0000033
GO:0016235	aggresome	Cellular Component	IBA	GO_REF:0000033
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005777	peroxisome	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IDA	PMID:11279055
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15885686
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:11279055
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IBA	GO_REF:0000033
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:11279055
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0140862	histone H2AK119 ubiquitin ligase activity	Molecular Function	IDA	PMID:25470042

Enzyme–Substrate Interactions ▾


O94972	TRI37	Yes	Yes	No	Yes	—	No	E3-specific

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