WDR47

Details:

UniProt Entry: O94967
Gene: WDR47
Class: Other E3 Components
Family: Adaptor
Protein length: 919
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O94967
MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ
WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHL EFTMQEAVQC
LHALEEYCPS KDDYSKLCLL LTLPRLTNHA EFKDWNPSTA RVHCFEEACV MVAEFIPADR
KLSEAGFKAS NNRLFQLVMK GLLYECCVEF CQSKATGEEI TESEVLLGID LLCGNGCDDL
DLSLLSWLQN LPSSVFSCAF EQKMLNIHVD KLLKPTKAAY ADLLTPLISK LSPYPSSPMR
RPQSADAYMT RSLNPALDGL TCGLTSHDKR ISDLGNKTSP MSHSFANFHY PGVQNLSRSL
MLENTECHSI YEESPERDTP VDAQRPIGSE ILGQSSVSEK EPANGAQNPG PAKQEKNELR
DSTEQFQEYY RQRLRYQQHL EQKEQQRQIY QQMLLEGGVN QEDGPDQQQN LTEQFLNRSI
QKLGELNIGM DGLGNEVSAL NQQCNGSKGN GSNGSSVTSF TTPPQDSSQR LTHDASNIHT
STPRNPGSTN HIPFLEESPC GSQISSEHSV IKPPLGDSPG SLSRSKGEED DKSKKQFVCI
NILEDTQAVR AVAFHPAGGL YAVGSNSKTL RVCAYPDVID PSAHETPKQP VVRFKRNKHH
KGSIYCVAWS PCGQLLATGS NDKYVKVLPF NAETCNATGP DLEFSMHDGT IRDLAFMEGP
ESGGAILISA GAGDCNIYTT DCQRGQGLHA LSGHTGHILA LYTWSGWMIA SGSQDKTVRF
WDLRVPSCVR VVGTTFHGTG SAVASVAVDP SGRLLATGQE DSSCMLYDIR GGRMVQSYHP
HSSDVRSVRF SPGAHYLLTG SYDMKIKVTD LQGDLTKQLP IMVVGEHKDK VIQCRWHTQD
LSFLSSSADR TVTLWTYNG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	918	Family	WD repeat-containing protein 47	IPR040067	PTHR19863
10	42	Domain	LIS1 homology motif	IPR006594	SM00667
10	42	Domain	LIS1 homology motif	IPR006594	PS50896
45	102	Domain	CTLH, C-terminal LisH motif	IPR006595	PS50897
45	102	Domain	CTLH, C-terminal LisH motif	IPR006595	SM00668
540	793	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
596	634	Repeat	WD40 repeat	IPR001680	SM00320
602	915	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
647	689	Repeat	WD40 repeat	IPR001680	SM00320
657	687	Repeat	WD40 repeat	IPR001680	PS50082
659	687	Repeat	WD40 repeat	IPR001680	PF00400
697	741	Repeat	WD40 repeat	IPR001680	SM00320
744	782	Repeat	WD40 repeat	IPR001680	SM00320
745	782	Repeat	WD40 repeat	IPR001680	PF00400
751	791	Repeat	WD40 repeat	IPR001680	PS50082
769	783	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
787	849	Domain	Anaphase-promoting complex subunit 4, WD40 domain	IPR024977	PF12894
789	828	Repeat	WD40 repeat	IPR001680	SM00320
794	919	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
796	837	Repeat	WD40 repeat	IPR001680	PS50082
831	870	Repeat	WD40 repeat	IPR001680	SM00320
838	872	Repeat	WD40 repeat	IPR001680	PS50082
877	916	Repeat	WD40 repeat	IPR001680	SM00320
884	919	Repeat	WD40 repeat	IPR001680	PS50082

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000226	microtubule cytoskeleton organization	Biological Process	IEA	GO_REF:0000107
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000107
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IEA	GO_REF:0000107
GO:0007420	brain development	Biological Process	IEA	GO_REF:0000107
GO:0007626	locomotory behavior	Biological Process	IEA	GO_REF:0000107
GO:0008344	adult locomotory behavior	Biological Process	IEA	GO_REF:0000107
GO:0021801	cerebral cortex radial glia-guided migration	Biological Process	IEA	GO_REF:0000107
GO:0021960	anterior commissure morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0021987	cerebral cortex development	Biological Process	IEA	GO_REF:0000107
GO:0022038	corpus callosum development	Biological Process	IEA	GO_REF:0000107
GO:0031175	neuron projection development	Biological Process	IEA	GO_REF:0000107
GO:0061351	neural precursor cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0061744	motor behavior	Biological Process	IEA	GO_REF:0000107
GO:0097150	neuronal stem cell population maintenance	Biological Process	IEA	GO_REF:0000107
GO:0120168	detection of hot stimulus involved in thermoception	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005874	microtubule	Cellular Component	IEA	GO_REF:0000120
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000107
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000107
GO:0030426	growth cone	Cellular Component	IEA	GO_REF:0000107
GO:0043005	neuron projection	Cellular Component	IEA	GO_REF:0000107
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.