RHBT3

Details:

UniProt Entry: O94955
Gene: RHOBTB3
Class: Other E3 Components
Family: Adaptor
Protein length: 611
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O94955
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA
SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK
RALNSVPVII AAVGTRQNEE LPCTCPLCTS DRGSCVSTTE GIQLAKELGA TYLELHSLDD
FYIGKYFGGV LEYFMIQALN QKTSEKMKKR KMSNSFHGIR PPQLEQPEKM PVLKAEASHY
NSDLNNLLFC CQCVDVVFYN PNLKKVVEAH KIVLCAVSHV FMLLFNVKSP TDIQDSSIIR
TTQDLFAINR DTAFPGASHE SSGNPPLRVI VKDALFCSCL SDILRFIYSG AFQWEELEED
IRKKLKDSGD VSNVIEKVKC ILKTPGKINC LRNCKTYQAR KPLWFYNTSL KFFLNKPMLA
DVVFEIQGTT VPAHRAILVA RCEVMAAMFN GNYMEAKSVL IPVYGVSKET FLSFLEYLYT
DSCCPAGIFQ AMCLLICAEM YQVSRLQHIC ELFIITQLQS MPSRELASMN LDIVDLLKKA
KFHHSDCLST WLLHFIATNY LIFSQKPEFQ DLSVEERSFV EKHRWPSNMY LKQLAEYRKY
IHSRKCRCLV M

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
42	215	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
65	192	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
88	188	Family	Small GTPase	IPR001806	PF00071
233	383	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
237	353	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
245	354	Domain	BTB/POZ domain	IPR000210	PF00651
254	356	Domain	BTB/POZ domain	IPR000210	PS50097
254	386	Domain	BTB/POZ domain	IPR000210	SM00225
398	517	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
406	565	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
414	517	Domain	BTB/POZ domain	IPR000210	PF00651
420	481	Domain	BTB/POZ domain	IPR000210	PS50097
420	518	Domain	BTB/POZ domain	IPR000210	SM00225

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0008584	male gonad development	Biological Process	IEA	GO_REF:0000107
GO:0030162	regulation of proteolysis	Biological Process	IBA	GO_REF:0000033
GO:0042147	retrograde transport, endosome to Golgi	Biological Process	IMP	PMID:19490898
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000108
GO:0032588	trans-Golgi network membrane	Cellular Component	TAS	Reactome:R-HSA-6814670
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:18570454
GO:0003924	GTPase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005525	GTP binding	Molecular Function	IEA	GO_REF:0000002
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:19490898
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016887	ATP hydrolysis activity	Molecular Function	IDA	PMID:19490898
GO:0031267	small GTPase binding	Molecular Function	IPI	PMID:19490898
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IBA	GO_REF:0000033

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