RNF37

Details:

UniProt Entry: O94941
Gene: UBOX5
Class: RING
Family: RING9
Protein length: 541
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O94941
MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN
VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK
VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV
TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP
ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG
RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP
SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP
LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG
PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH
F

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	541	Family	RING finger protein 37	IPR039847	PTHR13492
4	215	Domain	RING finger protein 37, N-terminal	IPR045696	PF19318
256	336	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
258	338	Domain	U-box domain	IPR003613	PS51698
259	336	Domain	U-box domain	IPR003613	PF04564
260	312	Domain	RNF37, RING-Ubox	IPR039925	cd16660
262	331	Domain	U-box domain	IPR003613	SM00504
478	541	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
483	528	Domain	Zinc finger, RING-type	IPR001841	PS50089
504	513	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005925	focal adhesion	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	PMID:11274149
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IBA	GO_REF:0000033
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

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