KLH18

Details:

UniProt Entry: O94889
Gene: KLHL18
Class: Other E3 Components
Family: Adaptor
Protein length: 574
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O94889
MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI
PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL
QSIKDACCTF LRERLHPKNC LGVRQFAETM MCAVLYDAAN SFIHQHFVEV SMSEEFLALP
LEDVLELVSR DELNVKSEEQ VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR
VQQDDLVRCC HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG
DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL STVEAYNPET
DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV ETYSPETDKW TVVTSMSSNR
SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY NHHTATWHPA AGMLNKRCRH GAASLGSKMF
VCGGYDGSGF LSIAEMYSSV ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS
VEMYDPETDC WTFMAPMACH EGGVGVGCIP LLTI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
6	574	Family	BTB-kelch protein	IPR017096	PIRSF037037
9	136	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
14	133	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
19	134	Domain	Kelch-like protein 18, BTB/POZ domain	IPR030603	cd18247
29	134	Domain	BTB/POZ domain	IPR000210	PF00651
38	135	Domain	BTB/POZ domain	IPR000210	SM00225
38	105	Domain	BTB/POZ domain	IPR000210	PS50097
140	242	Domain	BTB/Kelch-associated	IPR011705	PF07707
140	242	Domain	BTB/Kelch-associated	IPR011705	SM00875
262	442	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
271	440	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
280	322	Repeat	Kelch repeat type 1	IPR006652	PF01344
289	336	Repeat	Kelch repeat type 1	IPR006652	SM00612
325	370	Repeat	Kelch repeat type 1	IPR006652	PF01344
337	383	Repeat	Kelch repeat type 1	IPR006652	SM00612
373	417	Repeat	Kelch repeat type 1	IPR006652	PF01344
384	430	Repeat	Kelch repeat type 1	IPR006652	SM00612
420	560	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
420	463	Repeat	Kelch repeat type 1	IPR006652	PF01344
431	477	Repeat	Kelch repeat type 1	IPR006652	SM00612
443	569	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
467	510	Repeat	Kelch repeat type 1	IPR006652	PF01344
478	524	Repeat	Kelch repeat type 1	IPR006652	SM00612
513	557	Repeat	Kelch repeat type 1	IPR006652	PF01344
525	571	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:1901992	positive regulation of mitotic cell cycle phase transition	Biological Process	IMP	PMID:23213400
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:23213400
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.