NEUL1

Details:

UniProt Entry: O76050
Gene: NEURL1
Class: RING
Family: RING3
Protein length: 574
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O76050
MGNNFSSIPS LPRGNPSRAP RGHPQNLKDS IGGPFPVTSH RCHHKQKHCP AVLPSGGLPA
TPLLFHPHTK GSQILMDLSH KAVKRQASFC NAITFSNRPV LIYEQVRLKI TKKQCCWSGA
LRLGFTSKDP SRIHPDSLPK YACPDLVSQS GFWAKALPEE FANEGNIIAF WVDKKGRVFH
RINDSAVMLF FSGVRTADPL WALVDVYGLT RGVQLLDSEL VLPDCLRPRS FTALRRPSLR
READDARLSV SLCDLNVPGA DGDEAAPAAG CPIPQNSLNS QHSRALPAQL DGDLRFHALR
AGAHVRILDE QTVARVEHGR DERALVFTSR PVRVAETIFV KVTRSGGARP GALSFGVTTC
DPGTLRPADL PFSPEALVDR KEFWAVCRVP GPLHSGDILG LVVNADGELH LSHNGAAAGM
QLCVDASQPL WMLFGLHGTI TQIRILGSTI LAERGIPSLP CSPASTPTSP SALGSRLSDP
LLSTCSSGPL GSSAGGTAPN SPVSLPESPV TPGLGQWSDE CTICYEHAVD TVIYTCGHMC
LCYACGLRLK KALHACCPIC RRPIKDIIKT YRSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
44	572	Family	Neuralized	IPR037962	PTHR12429
60	183	Domain	Neuralized homology repeat (NHR) domain	IPR006573	SM00588
62	218	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PS51065
65	217	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PF07177
65	218	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
291	414	Domain	Neuralized homology repeat (NHR) domain	IPR006573	SM00588
293	448	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PS51065
295	447	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
296	447	Domain	Neuralized homology repeat (NHR) domain	IPR006573	PF07177
515	573	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
521	561	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007288	sperm axoneme assembly	Biological Process	IEA	GO_REF:0000107
GO:0007595	lactation	Biological Process	IEA	GO_REF:0000107
GO:0030317	flagellated sperm motility	Biological Process	IEA	GO_REF:0000107
GO:0006417	regulation of translation	Biological Process	IEA	GO_REF:0000043
GO:0006513	protein monoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0007219	Notch signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0007399	nervous system development	Biological Process	TAS	PMID:9519875
GO:0007519	skeletal muscle tissue development	Biological Process	IEA	GO_REF:0000120
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:20847082
GO:0010646	regulation of cell communication	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0023051	regulation of signaling	Biological Process	IEA	GO_REF:0000117
GO:0043065	positive regulation of apoptotic process	Biological Process	IDA	PMID:20847082
GO:0045746	negative regulation of Notch signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Biological Process	ISS	GO_REF:0000024
GO:0051491	positive regulation of filopodium assembly	Biological Process	ISS	GO_REF:0000024
GO:0060999	positive regulation of dendritic spine development	Biological Process	ISS	GO_REF:0000024
GO:0071230	cellular response to amino acid stimulus	Biological Process	ISS	GO_REF:0000024
GO:0090129	positive regulation of synapse maturation	Biological Process	ISS	GO_REF:0000024
GO:0150052	regulation of postsynapse assembly	Biological Process	IEA	GO_REF:0000107
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0014069	postsynaptic density	Cellular Component	IBA	GO_REF:0000033
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043197	dendritic spine	Cellular Component	ISS	GO_REF:0000024
GO:0043204	perikaryon	Cellular Component	ISS	GO_REF:0000024
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0097440	apical dendrite	Cellular Component	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:36931259
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0045182	translation regulator activity	Molecular Function	ISS	GO_REF:0000024
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O76083	PDE9A	Yes	Yes	No	No	—	No	E3-specific

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