RFPL1

Details:

UniProt Entry: O75677
Gene: RFPL1
Class: RING
Family: RING5
Protein length: 317
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O75677
MKRLSLVTTN RLSPHGNFLP LCTFPLAVDM AALFQEASSC PVCSDYLEKP MSLECGCAVC
FKCINSLQKE PHGEDLLCCC CSMVSQKNKI RPSWQLERLA SHIKELEPKL KKILQMNPRM
RKFQVDMTLD ADTANNFLLI SDDLRSVRSG CITQNRQDLA ERFDVSICIL GSPRFTCGRH
YWEVDVGTST EWDLGVCRES VHRKGRIHLT TERGFWTVSL RDGSRLSAST VPLTFLFVDR
KLQRVGIFLD MGMQNVSFFD AEGGSHVYTF RSVSAEEPLH LFFAPPSPPN GDKSVLSICP
VINPGTTDAP VHPGEAK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
27	112	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
40	82	Domain	Zinc finger, RING-type	IPR001841	PS50089
83	124	Domain	RDM domain, Ret finger protein-like	IPR022723	PF11002
107	301	Domain	B30.2/SPRY domain	IPR001870	PS50188
117	314	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
117	301	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
122	299	Domain	Ret finger protein-like, SPRY/PRY domain	IPR037960	cd15821
123	140	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
124	176	Domain	SPRY-associated	IPR006574	SM00589
128	175	Domain	SPRY-associated	IPR006574	PF13765
140	157	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
162	186	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
177	302	Domain	SPRY domain	IPR003877	SM00449
179	282	Domain	SPRY domain	IPR003877	PF00622
192	205	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
236	260	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
267	285	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	Biological Process	IDA	PMID:20725088
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:20725088
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

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