FBX24

Details:

UniProt Entry: O75426
Gene: FBXO24
Class: Other E3 Components
Family: Receptor
Protein length: 580
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O75426
MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV
ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR
RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL
CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF
HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH
LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL
FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL
VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH
DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK
EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	115	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
36	82	Domain	F-box domain	IPR001810	PS50181
42	82	Domain	F-box domain	IPR001810	SM00256
43	85	Domain	F-box domain	IPR001810	PF12937
220	481	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
259	465	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
376	425	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
376	422	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000107
GO:0007005	mitochondrion organization	Biological Process	IEA	GO_REF:0000107
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000107
GO:0007338	single fertilization	Biological Process	IEA	GO_REF:0000107
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0034587	piRNA processing	Biological Process	IEA	GO_REF:0000107
GO:0035082	axoneme assembly	Biological Process	IEA	GO_REF:0000107
GO:0044782	cilium organization	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	NAS	PMID:10531035
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	NAS	PMID:10531035
GO:0005515	protein binding	Molecular Function	IPI	PMID:22939624

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.