TRIM3

Details:

UniProt Entry: O75382
Gene: TRIM3
Class: RING
Family: RING8
Protein length: 744
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 7o0b, 7qrw

Protein Sequence ▾

>O75382
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI PAQSLTLSCP
VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSVVAG RPLSCPNHEG
KTMEFYCEAC ETAMCGECRA GEHREHGTVL LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI
ALVGGISQQL QERKAEALAQ ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT
LRQGQEHIGS SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL
EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK DGRLVRTGSA
ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL SVLLYGQPVR GSPFRVRALR
PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV RRPSSMYSTG GKRKDNPIED ELVFRVGSRG
REKGEFTNLQ GVSAASSGRI VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA
VDTNGDIIVA DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF
TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS ADGEFLFKFG
SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG SFLSYINTSA EPLYGPQGLA
LTSDGHVVVA DAGNHCFKAY RYLQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
14	97	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
22	60	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
22	62	Domain	Zinc finger, RING-type	IPR001841	SM00184
22	63	Domain	Zinc finger, RING-type	IPR001841	PS50089
37	46	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
110	151	Domain	B-box-type zinc finger	IPR000315	SM00336
110	151	Domain	B-box-type zinc finger	IPR000315	PS50119
114	150	Domain	B-box-type zinc finger	IPR000315	PF00643
158	284	Domain	B-box, C-terminal	IPR003649	SM00502
317	418	Repeat	Filamin/ABP280 repeat-like	IPR017868	PS50194
319	421	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
321	415	Repeat	Filamin/ABP280 repeat-like	IPR017868	PF00630
321	421	Repeat	Filamin/ABP280 repeat	IPR001298	SM00557
322	418	Homologous_superfamily	Immunoglobulin E-set	IPR014756	SSF81296
464	660	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
473	516	Repeat	NHL repeat	IPR001258	PS51125
486	513	Repeat	NHL repeat	IPR001258	PF01436
520	563	Repeat	NHL repeat	IPR001258	PS51125
533	560	Repeat	NHL repeat	IPR001258	PF01436
564	605	Repeat	NHL repeat	IPR001258	PS51125
576	602	Repeat	NHL repeat	IPR001258	PF01436
609	652	Repeat	NHL repeat	IPR001258	PS51125
622	649	Repeat	NHL repeat	IPR001258	PF01436
656	699	Repeat	NHL repeat	IPR001258	PS51125
661	742	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
669	696	Repeat	NHL repeat	IPR001258	PF01436
700	743	Repeat	NHL repeat	IPR001258	PS51125
713	737	Repeat	NHL repeat	IPR001258	PF01436

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002224	toll-like receptor signaling pathway	Biological Process	IDA	PMID:12471095
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0007399	nervous system development	Biological Process	TAS	PMID:10391919
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	Biological Process	IDA	PMID:32878999
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0061351	neural precursor cell proliferation	Biological Process	IMP	PMID:38225354
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:32878999
GO:0005794	Golgi apparatus	Cellular Component	IDA	PMID:32878999
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000044
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	TAS	PMID:10391919
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q5VSY0	GKAP1	Yes	Yes	No	No	—	No	E3-specific

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