SOCS5

Details:

UniProt Entry: O75159
Gene: SOCS5
Class: Other E3 Components
Family: Receptor
Protein length: 536
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O75159
MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR
ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW
GGKKKHSCST KTQSSLDADK KFGRTRSGLQ RRERRYGVSS VHDMDSVSSR TVGSRSLRQR
LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH VSRQGAWKVH
TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF
PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
146	196	Domain	SOCS4/SOCS5 domain	IPR022252	PF12610
362	532	Homologous_superfamily	SH2 domain superfamily	IPR036860	G3DSA:3.30.505.10
370	474	Homologous_superfamily	SH2 domain superfamily	IPR036860	SSF55550
379	465	Domain	SH2 domain	IPR000980	SM00252
381	476	Domain	SH2 domain	IPR000980	PS50001
382	436	Domain	SH2 domain	IPR000980	PF00017
471	520	Domain	SOCS box domain	IPR001496	PS50225
475	518	Domain	SOCS box domain	IPR001496	SM00253
479	534	Domain	SOCS5, SOCS box domain	IPR037343	cd03739
481	515	Domain	SOCS box domain	IPR001496	PF07525
481	517	Domain	SOCS box domain	IPR001496	SM00969
482	523	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	Biological Process	IDA	PMID:15590694
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	IEA	GO_REF:0000002
GO:0009968	negative regulation of signal transduction	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019221	cytokine-mediated signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0032715	negative regulation of interleukin-6 production	Biological Process	IEA	GO_REF:0000107
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0045627	positive regulation of T-helper 1 cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045629	negative regulation of T-helper 2 cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0050728	negative regulation of inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0071404	cellular response to low-density lipoprotein particle stimulus	Biological Process	IEA	GO_REF:0000107
GO:0071638	negative regulation of monocyte chemotactic protein-1 production	Biological Process	IEA	GO_REF:0000107
GO:0097699	vascular endothelial cell response to fluid shear stress	Biological Process	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-6785821
GO:0005154	epidermal growth factor receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:15590694
GO:0030971	receptor tyrosine kinase binding	Molecular Function	IPI	PMID:15590694

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