BRE1B

Details:

UniProt Entry: O75150
Gene: RNF40
Class: RING
Family: RING9
Protein length: 1001
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O75150
MSGPGNKRAA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK VLQFKNKKLA
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLR CHESQGELSS
APEAPGTQEG PTCDGTPLPE PGTSELRDPL LMQLRPPLSE PALAFVVALG ASSSEEVELE
LQGRMEFSKA AVSRVVEASD RLQRRVEELC QRVYSRGDSE PLSEAAQAHT RELGRENRRL
QDLATQLQEK HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM AELEKLQAEL
QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN ESLQVKTQLD EARGLLLATK
NSHLRHIEHM ESDELGLQKK LRTEVIQLED TLAQVRKEYE MLRIEFEQNL AANEQAGPIN
REMRHLISSL QNHNHQLKGD AQRYKRKLRE VQAEIGKLRA QASGSAHSTP NLGHPEDSGV
SAPAPGKEEG GPGPVSTPDN RKEMAPVPGT TTTTTSVKKE ELVPSEEDFQ GITPGAQGPS
SRGREPEARP KRELREREGP SLGPPPVASA LSRADREKAK VEETKRKESE LLKGLRAELK
KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV DELRSRIREL EERDRRESKK
IADEDALRRI RQAEEQIEHL QRKLGATKQE EEALLSEMDV TGQAFEDMQE QNGRLLQQLR
EKDDANFKLM SERIKANQIH KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG
SLGGVEKELT LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC CNTRKKDAVL
TKCFHVFCFE CVRGRYEARQ RKCPKCNAAF GAHDFHRIYI S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	1000	Family	E3 ubiquitin ligase Bre1	IPR013956	PTHR23163
928	1001	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
948	986	Domain	Zinc finger, RING-type	IPR001841	SM00184
948	987	Domain	Zinc finger, RING-type	IPR001841	PS50089
948	986	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
963	972	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0007346	regulation of mitotic cell cycle	Biological Process	IMP	PMID:19575011
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:16307923
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0033503	HULC complex	Cellular Component	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:16307923
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003730	mRNA 3'-UTR binding	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:10944455
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:16307923
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:10944455

Enzyme–Substrate Interactions ▾


Q16623	STX1A	Yes	Yes	No	No	—	No	E3-specific

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