TRI13

Details:

UniProt Entry: O60858
Gene: TRIM13
Class: RING
Family: RING5
Protein length: 407
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O60858
MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE
TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR
GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD
KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK
DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP
QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK
TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	84	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
10	55	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
10	58	Domain	Zinc finger, RING-type	IPR001841	PS50089
10	57	Domain	Zinc finger, RING-type	IPR001841	SM00184
25	34	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
89	131	Domain	B-box-type zinc finger	IPR000315	SM00336
89	131	Domain	B-box-type zinc finger	IPR000315	PS50119
90	131	Domain	B-box-type zinc finger	IPR000315	PF00643

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0016239	positive regulation of macroautophagy	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:17314412
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:17314412
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0097038	perinuclear endoplasmic reticulum	Cellular Component	IDA	PMID:17314412
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:17314412
GO:0005515	protein binding	Molecular Function	IPI	PMID:17314412
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0061659	ubiquitin-like protein ligase activity	Molecular Function	IDA	PMID:21333377

Enzyme–Substrate Interactions ▾


P22736	NR4A1	Yes	No	No	No	—	No	E3-specific
O60858	TRI13	Yes	Yes	No	No	22829933	EBI-9867343	E3-specific
P55072	TERA	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P22736	NR4A1	Yes	No	No	No	—	No	E3-specific
O60858	TRI13	Yes	Yes	No	No	22829933	EBI-9867343	E3-specific
P55072	TERA	Yes	Yes	No	No	—	No	E3-specific