KLH41

Details:

UniProt Entry: O60662
Gene: KLHL41
Class: Other E3 Components
Family: Adaptor
Protein length: 606
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O60662
MDSQRELAEE LRLYQSTLLQ DGLKDLLDEK KFIDCTLKAG DKSLPCHRLI LSACSPYFRE
YFLSEIDEAK KKEVVLDNVD PAILDLIIKY LYSASIDLND GNVQDIFALA SRFQIPSVFT
VCVSYLQKRL APGNCLAILR LGLLLDCPRL AISAREFVSD RFVQICKEED FMQLSPQELI
SVISNDSLNV EKEEAVFEAV MKWVRTDKEN RVKNLSEVFD CIRFRLMTEK YFKDHVEKDD
IIKSNPDLQK KIKVLKDAFA GKLPEPSKNA AKTGAGEVNG DVGDEDLLPG YLNDIPRHGM
FVKDLILLVN DTAAVAYDPT ENECYLTALA EQIPRNHSSI VTQQNQIYVV GGLYVDEENK
DQPLQSYFFQ LDSIASEWVG LPPLPSARCL FGLGEVDDKI YVVAGKDLQT EASLDSVLCY
DPVAAKWNEV KKLPIKVYGH NVISHKGMIY CLGGKTDDKK CTNRVFIFNP KKGDWKDLAP
MKIPRSMFGV AVHKGKIVIA GGVTEDGLSA SVEAFDLTTN KWDVMTEFPQ ERSSISLVSL
AGSLYAIGGF AMIQLESKEF APTEVNDIWK YEDDKKEWAG MLKEIRYASG ASCLATRLNL
FKLSKL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	131	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
1	601	Family	BTB-kelch protein	IPR017096	PIRSF037037
17	128	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	129	Domain	BTB/POZ domain	IPR000210	PF00651
33	100	Domain	BTB/POZ domain	IPR000210	PS50097
33	130	Domain	BTB/POZ domain	IPR000210	SM00225
135	237	Domain	BTB/Kelch-associated	IPR011705	SM00875
135	237	Domain	BTB/Kelch-associated	IPR011705	PF07707
289	606	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
314	593	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
334	385	Repeat	Kelch repeat type 1	IPR006652	PF01344
346	398	Repeat	Kelch repeat type 1	IPR006652	SM00612
387	434	Repeat	Kelch repeat type 1	IPR006652	PF01344
399	447	Repeat	Kelch repeat type 1	IPR006652	SM00612
438	481	Repeat	Kelch repeat type 1	IPR006652	PF01344
448	495	Repeat	Kelch repeat type 1	IPR006652	SM00612
484	527	Repeat	Kelch repeat type 1	IPR006652	PF01344
496	542	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:2001014	regulation of skeletal muscle cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0006941	striated muscle contraction	Biological Process	TAS	PMID:9655184
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:15983046
GO:0030239	myofibril assembly	Biological Process	ISS	GO_REF:0000024
GO:0035914	skeletal muscle cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045661	regulation of myoblast differentiation	Biological Process	ISS	GO_REF:0000024
GO:2000291	regulation of myoblast proliferation	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IBA	GO_REF:0000033
GO:0031430	M band	Cellular Component	IBA	GO_REF:0000033
GO:0033017	sarcoplasmic reticulum membrane	Cellular Component	IBA	GO_REF:0000033
GO:0001726	ruffle	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016529	sarcoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0031143	pseudopodium	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:23414517
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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