MARH6

Details:

UniProt Entry: O60337
Gene: MARCHF6
Class: RING
Family: RING7
Protein length: 910
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O60337
MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE YCELCKHRFA
FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA FAWLGVVPLT ACRIYKCLFT
GSVSSLLTLP LDMLSTENLL ADCLQGCFVV TCTLCAFISL VWLREQIVHG GAPIWLEHAA
PPFNAAGHHQ NEAPAGGNGA ENVAADQPAN PPAENAVVGE NPDAQDDQAE EEEEDNEEED
DAGVEDAADA NNGAQDDMNW NALEWDRAAE ELTWERMLGL DGSLVFLEHV FWVVSLNTLF
ILVFAFCPYH IGHFSLVGLG FEEHVQASHF EGLITTIVGY ILLAITLIIC HGLATLVKFH
RSRRLLGVCY IVVKVSLLVV VEIGVFPLIC GWWLDICSLE MFDATLKDRE LSFQSAPGTT
MFLHWLVGMV YVFYFASFIL LLREVLRPGV LWFLRNLNDP DFNPVQEMIH LPIYRHLRRF
ILSVIVFGSI VLLMLWLPIR IIKSVLPNFL PYNVMLYSDA PVSELSLELL LLQVVLPALL
EQGHTRQWLK GLVRAWTVTA GYLLDLHSYL LGDQEENENS ANQQVNNNQH ARNNNAIPVV
GEGLHAAHQA ILQQGGPVGF QPYRRPLNFP LRIFLLIVFM CITLLIASLI CLTLPVFAGR
WLMSFWTGTA KIHELYTAAC GLYVCWLTIR AVTVMVAWMP QGRRVIFQKV KEWSLMIMKT
LIVAVLLAGV VPLLLGLLFE LVIVAPLRVP LDQTPLFYPW QDWALGVLHA KIIAAITLMG
PQWWLKTVIE QVYANGIRNI DLHYIVRKLA APVISVLLLS LCVPYVIASG VVPLLGVTAE
MQNLVHRRIY PFLLMVVVLM AILSFQVRQF KRLYEHIKND KYLVGQRLVN YERKSGKQGS
SPPPPQSSQE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	67	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1	62	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
8	56	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
9	55	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006695	cholesterol biosynthetic process	Biological Process	IC	PMID:30626872
GO:0010498	proteasomal protein catabolic process	Biological Process	IDA	PMID:15673284
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:24449766
GO:0045541	negative regulation of cholesterol biosynthetic process	Biological Process	IDA	PMID:32755570
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:15673284
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0000835	ER ubiquitin ligase complex	Cellular Component	IC	PMID:15673284
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15673284
GO:0005515	protein binding	Molecular Function	IPI	PMID:25766235
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:19651899
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IPI	PMID:15673284
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:1990381	ubiquitin-specific protease binding	Molecular Function	IPI	PMID:25088257

Enzyme–Substrate Interactions ▾


Q14534	ERG1	Yes	Yes	No	No	24449766	EBI-10815110	E3-specific
O60337	MARH6	Yes	No	No	No	—	No	E3-specific
Q92813	IOD2	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q14534	ERG1	Yes	Yes	No	No	24449766	EBI-10815110	E3-specific
O60337	MARH6	Yes	No	No	No	—	No	E3-specific
Q92813	IOD2	Yes	Yes	No	No	—	No	E3-specific