MGRN1

Details:

UniProt Entry: O60291
Gene: MGRN1
Class: RING
Family: RING9
Protein length: 552
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>O60291
MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL
NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KDDADSPTED GDKPRVLYSL
EFTFDADARV AITIYCQASE EFLNGRAVYS PKSPSLQSET VHYKRGVSQQ FSLPSFKIDF
SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHMDG SFSVKPLKQK
QIVDRVSYLL QEIYGIENKN NQETKPSDDE NSDNSNECVV CLSDLRDTLI LPCRHLCLCT
SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPVS FSPVLAQSLE HDEHSCPFKK
SKPHPASLAS KKPKRETNSD SVPPGYEPIS LLEALNGLRA VSPAIPSAPL YEEITYSGIS
DGLSQASCPL AAIDHILDSS RQKGRPQSKA PDSTLRSPSS PIHEEDEEKL SEDVDAPPPL
GGAELALRES SSPESFITEE VDESSSPQQG TRAASIENVL QDSSPEHCGR GPPADIYLPA
LGPDSCSVGI DE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	342	Family	E3 ubiquitin-protein ligase MGRN1/RNF157-like	IPR045194	PTHR22996
254	327	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
277	317	Domain	LOG2-like, modified RING finger, C3HC5-type	IPR045195	cd16789
278	317	Domain	Zinc finger, RING-type	IPR001841	PS50089
278	316	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0007224	smoothened signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0007507	heart development	Biological Process	IEA	GO_REF:0000107
GO:0065003	protein-containing complex assembly	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IMP	PMID:17229889
GO:0008333	endosome to lysosome transport	Biological Process	IBA	GO_REF:0000033
GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Biological Process	IDA	PMID:19737927
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005769	early endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:17229889

Enzyme–Substrate Interactions ▾

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