PRKN

>O60260
MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD
LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA
VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP
SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT
CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE
LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC
GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR
CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	72	Domain	Ubiquitin-like domain	IPR000626	PS50053
1	72	Domain	Ubiquitin-like domain	IPR000626	SM00213
1	464	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PIRSF037880
1	76	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
3	72	Domain	Ubiquitin-like domain	IPR000626	PF00240
30	50	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
145	217	Domain	Parkin, RING/Ubox like zinc-binding domain	IPR041565	PF17976
154	169	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
175	198	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
188	453	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
205	215	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
221	241	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
228	318	Domain	RING/Ubox-like zinc-binding domain	IPR041170	PF17978
234	465	Domain	TRIAD supradomain	IPR044066	PS51873
249	265	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
300	321	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
313	377	Domain	IBR domain	IPR002867	SM00647
329	345	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475
401	457	Domain	IBR domain	IPR002867	SM00647
441	463	Family	E3 ubiquitin-protein ligase parkin	IPR003977	PR01475

GO term	Name	Ontology	Evidence	Reference
GO:0009893	positive regulation of metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0001963	synaptic transmission, dopaminergic	Biological Process	IEA	GO_REF:0000107
GO:0001964	startle response	Biological Process	IEA	GO_REF:0000107
GO:0007612	learning	Biological Process	IEA	GO_REF:0000107
GO:0007626	locomotory behavior	Biological Process	IEA	GO_REF:0000107
GO:0008344	adult locomotory behavior	Biological Process	IEA	GO_REF:0000107
GO:0033132	negative regulation of glucokinase activity	Biological Process	IDA	PMID:24187134
GO:0035249	synaptic transmission, glutamatergic	Biological Process	IEA	GO_REF:0000107
GO:0042415	norepinephrine metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0042417	dopamine metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0046676	negative regulation of insulin secretion	Biological Process	IDA	PMID:24187134
GO:0046928	regulation of neurotransmitter secretion	Biological Process	IEA	GO_REF:0000107
GO:0050804	modulation of chemical synaptic transmission	Biological Process	IEA	GO_REF:0000120
GO:0051583	dopamine uptake involved in synaptic transmission	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IMP	PMID:23985028
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:12150907
GO:0000266	mitochondrial fission	Biological Process	ISS	GO_REF:0000024
GO:0000422	autophagy of mitochondrion	Biological Process	IMP	PMID:19029340
GO:0000423	mitophagy	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:20889974
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0006979	response to oxidative stress	Biological Process	ISS	GO_REF:0000024
GO:0006986	response to unfolded protein	Biological Process	IEA	GO_REF:0000107
GO:0007005	mitochondrion organization	Biological Process	ISS	GO_REF:0000024
GO:0007417	central nervous system development	Biological Process	TAS	PMID:9560156
GO:0009410	response to xenobiotic stimulus	Biological Process	IEA	GO_REF:0000107
GO:0009896	positive regulation of catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010498	proteasomal protein catabolic process	Biological Process	IMP	PMID:19725078
GO:0010506	regulation of autophagy	Biological Process	IDA	PMID:20889974
GO:0010628	positive regulation of gene expression	Biological Process	IMP	PMID:19725078
GO:0010629	negative regulation of gene expression	Biological Process	IMP	PMID:19725078
GO:0010636	positive regulation of mitochondrial fusion	Biological Process	IMP	PMID:23453807
GO:0010637	negative regulation of mitochondrial fusion	Biological Process	ISS	GO_REF:0000024
GO:0010821	regulation of mitochondrion organization	Biological Process	IBA	GO_REF:0000033
GO:0010906	regulation of glucose metabolic process	Biological Process	TAS	PMID:23626584
GO:0010918	positive regulation of mitochondrial membrane potential	Biological Process	IEA	GO_REF:0000107
GO:0010994	free ubiquitin chain polymerization	Biological Process	IMP	PMID:24660806
GO:0014059	regulation of dopamine secretion	Biological Process	TAS	PMID:21563316
GO:0014850	response to muscle activity	Biological Process	IEA	GO_REF:0000107
GO:0016236	macroautophagy	Biological Process	TAS	Reactome:R-HSA-5205685
GO:0016579	protein deubiquitination	Biological Process	TAS	Reactome:R-HSA-5688426
GO:0022603	regulation of anatomical structure morphogenesis	Biological Process	IEA	GO_REF:0000117
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0031396	regulation of protein ubiquitination	Biological Process	IMP	PMID:20871098
GO:0031647	regulation of protein stability	Biological Process	IMP	PMID:26911690
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000107
GO:0032232	negative regulation of actin filament bundle assembly	Biological Process	IDA	PMID:17512523
GO:0032368	regulation of lipid transport	Biological Process	TAS	PMID:23626584
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0034599	cellular response to oxidative stress	Biological Process	IEA	GO_REF:0000107
GO:0034620	cellular response to unfolded protein	Biological Process	TAS	PMID:18221368
GO:0034976	response to endoplasmic reticulum stress	Biological Process	IEA	GO_REF:0000120
GO:0035519	protein K29-linked ubiquitination	Biological Process	TAS	PMID:23626584
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Biological Process	IEA	GO_REF:0000107
GO:0036503	ERAD pathway	Biological Process	NAS	PMID:10973942
GO:0042053	regulation of dopamine metabolic process	Biological Process	IMP	PMID:22314364
GO:0042981	regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0043065	positive regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:17314283
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:11439185
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IEA	GO_REF:0000120
GO:0043653	mitochondrial fragmentation involved in apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0044314	protein K27-linked ubiquitination	Biological Process	TAS	PMID:20098416
GO:0044828	negative regulation by host of viral genome replication	Biological Process	IDA	PMID:25244949
GO:0045732	positive regulation of protein catabolic process	Biological Process	TAS	PMID:22988876
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:23453807
GO:0046329	negative regulation of JNK cascade	Biological Process	ISS	GO_REF:0000024
GO:0050821	protein stabilization	Biological Process	IMP	PMID:19229105
GO:0051412	response to corticosterone	Biological Process	IEA	GO_REF:0000107
GO:0051582	positive regulation of neurotransmitter uptake	Biological Process	IMP	PMID:22314364
GO:0051646	mitochondrion localization	Biological Process	IEA	GO_REF:0000107
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:12628165
GO:0051881	regulation of mitochondrial membrane potential	Biological Process	IEA	GO_REF:0000107
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process	IEA	GO_REF:0000107
GO:0060544	regulation of necroptotic process	Biological Process	TAS	Reactome:R-HSA-5675482
GO:0060828	regulation of canonical Wnt signaling pathway	Biological Process	TAS	PMID:24115276
GO:0061734	type 2 mitophagy	Biological Process	IDA	PMID:19029340
GO:0065008	regulation of biological quality	Biological Process	IEA	GO_REF:0000117
GO:0070050	neuron cellular homeostasis	Biological Process	ISS	GO_REF:0000024
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:15728840
GO:0070585	protein localization to mitochondrion	Biological Process	IEA	GO_REF:0000120
GO:0070842	aggresome assembly	Biological Process	IMP	PMID:14645198
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:21376232
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:25621951
GO:0071287	cellular response to manganese ion	Biological Process	IEA	GO_REF:0000107
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0085020	protein K6-linked ubiquitination	Biological Process	TAS	PMID:23626584
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	IDA	PMID:19591802
GO:0090141	positive regulation of mitochondrial fission	Biological Process	ISS	GO_REF:0000024
GO:0090201	negative regulation of release of cytochrome c from mitochondria	Biological Process	IDA	PMID:19880420
GO:0090258	negative regulation of mitochondrial fission	Biological Process	IEA	GO_REF:0000107
GO:0090394	negative regulation of excitatory postsynaptic potential	Biological Process	IEA	GO_REF:0000107
GO:0097237	cellular response to toxic substance	Biological Process	IEA	GO_REF:0000107
GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Biological Process	IEA	GO_REF:0000107
GO:0099074	mitochondrion to lysosome vesicle-mediated transport	Biological Process	IDA	PMID:24446486
GO:0140251	regulation protein catabolic process at presynapse	Biological Process	IEA	GO_REF:0000107
GO:1900242	regulation of synaptic vesicle endocytosis	Biological Process	IEA	GO_REF:0000107
GO:1900407	regulation of cellular response to oxidative stress	Biological Process	ISS	GO_REF:0000024
GO:1901526	positive regulation of mitophagy	Biological Process	IEA	GO_REF:0000107
GO:1901800	positive regulation of proteasomal protein catabolic process	Biological Process	IGI	PMID:23858059
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Biological Process	IMP	PMID:23985028
GO:1902530	positive regulation of protein linear polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:1902803	regulation of synaptic vesicle transport	Biological Process	NAS	PMID:21563316
GO:1903214	regulation of protein targeting to mitochondrion	Biological Process	NAS	PMID:20890124
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IDA	PMID:23453807
GO:1903351	cellular response to dopamine	Biological Process	TAS	PMID:23626584
GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:1903382	negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Biological Process	IEA	GO_REF:0000107
GO:1903530	regulation of secretion by cell	Biological Process	IEA	GO_REF:0000117
GO:1903542	negative regulation of exosomal secretion	Biological Process	IMP	PMID:26911690
GO:1903861	positive regulation of dendrite extension	Biological Process	IEA	GO_REF:0000107
GO:1904049	negative regulation of spontaneous neurotransmitter secretion	Biological Process	IMP	PMID:22314364
GO:1904643	response to curcumin	Biological Process	IEA	GO_REF:0000107
GO:1904845	cellular response to L-glutamine	Biological Process	IEA	GO_REF:0000107
GO:1904881	cellular response to hydrogen sulfide	Biological Process	IEA	GO_REF:0000107
GO:1905091	positive regulation of type 2 mitophagy	Biological Process	IDA	PMID:20457763
GO:1905232	cellular response to L-glutamate	Biological Process	IEA	GO_REF:0000107
GO:1905281	positive regulation of retrograde transport, endosome to Golgi	Biological Process	NAS	PMID:26911690
GO:1905366	negative regulation of intralumenal vesicle formation	Biological Process	IMP	PMID:26911690
GO:1905477	positive regulation of protein localization to membrane	Biological Process	IC	PMID:26911690
GO:1990000	amyloid fibril formation	Biological Process	TAS	Reactome:R-HSA-977225
GO:2000377	regulation of reactive oxygen species metabolic process	Biological Process	IMP	PMID:18541373
GO:2000378	negative regulation of reactive oxygen species metabolic process	Biological Process	IGI	PMID:18541373
GO:2001171	positive regulation of ATP biosynthetic process	Biological Process	IEA	GO_REF:0000107
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000002
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000002
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:12628165
GO:0099073	mitochondrion-derived vesicle	Cellular Component	IDA	PMID:24446486
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IBA	GO_REF:0000033
GO:0098691	dopaminergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098794	postsynapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000107
GO:0008021	synaptic vesicle	Cellular Component	IEA	GO_REF:0000107
GO:0014069	postsynaptic density	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016235	aggresome	Cellular Component	IDA	PMID:14645198
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000107
GO:0030672	synaptic vesicle membrane	Cellular Component	IEA	GO_REF:0000107
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043005	neuron projection	Cellular Component	IEA	GO_REF:0000120
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0043195	terminal bouton	Cellular Component	IEA	GO_REF:0000107
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000120
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0097413	Lewy body	Cellular Component	TAS	PMID:24522549
GO:0097708	intracellular vesicle	Cellular Component	IEA	GO_REF:0000107
GO:0098793	presynapse	Cellular Component	IEA	GO_REF:0000120
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0032991	protein-containing complex	Cellular Component	IEA	GO_REF:0000107
GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	Cellular Component	IPI	PMID:12628165
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043
GO:0001664	G protein-coupled receptor binding	Molecular Function	IPI	PMID:12150907
GO:0003714	transcription corepressor activity	Molecular Function	IDA	PMID:23985028
GO:0003779	actin binding	Molecular Function	IPI	PMID:21753002
GO:0005515	protein binding	Molecular Function	IPI	PMID:10888878
GO:0008013	beta-catenin binding	Molecular Function	IDA	PMID:19591802
GO:0015631	tubulin binding	Molecular Function	IPI	PMID:21753002
GO:0017124	SH3 domain binding	Molecular Function	TAS	PMID:23626584
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:19725078
GO:0019900	kinase binding	Molecular Function	IPI	PMID:17512523
GO:0019901	protein kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0030165	PDZ domain binding	Molecular Function	IPI	PMID:17512523
GO:0030544	Hsp70 protein binding	Molecular Function	IPI	PMID:12150907
GO:0031072	heat shock protein binding	Molecular Function	IPI	PMID:12150907
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:12150907
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:21694720
GO:0042826	histone deacetylase binding	Molecular Function	IPI	PMID:21753002
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:24784582
GO:0043274	phospholipase binding	Molecular Function	IPI	PMID:19725078
GO:0044877	protein-containing complex binding	Molecular Function	IEA	GO_REF:0000107
GO:0051087	protein-folding chaperone binding	Molecular Function	IPI	PMID:15603737
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0097602	cullin family protein binding	Molecular Function	IDA	PMID:12628165
GO:1990381	ubiquitin-specific protease binding	Molecular Function	IPI	PMID:24063750
GO:1990444	F-box domain binding	Molecular Function	IPI	PMID:12628165

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q70CQ3	UBP30	Yes	Yes	No	No	—	No	E3-specific
P19367	HXK1	Yes	Yes	No	No	—	No	E3-specific
Q9NZ45	CISD1	Yes	Yes	No	No	—	No	E3-specific
Q15388	TOM20	Yes	Yes	No	No	—	No	E3-specific
Q96QK1	VPS35	Yes	No	No	No	—	No	E3-specific
P21796	VDAC1	Yes	Yes	No	No	—	No	E3-specific
O43175	SERA	Yes	Yes	No	No	—	No	E3-specific
Q99648	Q99648	Yes	No	No	No	—	No	E3-specific
Q9NX09	DDIT4	Yes	Yes	No	Yes	—	No	E3-specific
Q99719	SEPT5	Yes	Yes	No	No	24722188	EBI-21251377	E3-specific
Q99714	HCD2	Yes	Yes	No	No	—	No	E3-specific
Q13155	AIMP2	Yes	Yes	No	No	—	No	E3-specific
O96020	CCNE2	Yes	Yes	No	No	—	No	E3-specific
P07437	TBB5	Yes	Yes	No	No	25959826	EBI-21135687	E3-specific
Q9BT88	SYT11	Yes	Yes	Yes	No	32814053	EBI-25880275	E3-specific
Q16342	PDCD2	Yes	Yes	Yes	No	19146857	EBI-8545628	E3-specific
Q9NRD5	PICK1	Yes	Yes	No	Yes	—	No	E3-specific
P49792	RBP2	Yes	Yes	Yes	No	16332688	EBI-973952	E3-specific
Q8IXI1	MIRO2	Yes	Yes	No	No	—	No	E3-specific
Q99963	SH3G3	Yes	Yes	No	No	25471590	EBI-10689135	E3-specific
Q9UNN5	FAF1	Yes	Yes	No	No	—	No	E3-specific
O60883	G37L1	Yes	Yes	No	No	—	No	E3-specific
Q8IXI2	MIRO1	Yes	Yes	Yes	No	22078885	EBI-5281459	E3-specific
P10415	BCL2	Yes	Yes	No	No	—	No	E3-specific
Q96AE4	FUBP1	Yes	Yes	No	No	—	No	E3-specific
P68363	TBA1B	Yes	Yes	No	No	—	No	E3-specific
Q07812	BAX	Yes	Yes	No	No	—	No	Cluster-specific
Q14190	SIM2	Yes	Yes	Yes	No	32814053	EBI-25879757	Cluster-specific