ZBT14

Details:

UniProt Entry: O43829
Gene: ZBTB14
Class: RING
Family: RING6
Protein length: 449
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>O43829
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL
DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG
TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT
FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP
FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP
SAIQSETEQL QAAAMAAEAE QQLETIACS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	152	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
13	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
26	128	Domain	BTB/POZ domain	IPR000210	PF00651
36	102	Domain	BTB/POZ domain	IPR000210	PS50097
36	132	Domain	BTB/POZ domain	IPR000210	SM00225
277	299	Domain	Zinc finger C2H2-type	IPR013087	SM00355
277	304	Domain	Zinc finger C2H2-type	IPR013087	PS50157
278	327	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
279	299	Domain	Zinc finger C2H2-type	IPR013087	PS00028
305	327	Domain	Zinc finger C2H2-type	IPR013087	SM00355
305	327	Domain	Zinc finger C2H2-type	IPR013087	PF00096
305	332	Domain	Zinc finger C2H2-type	IPR013087	PS50157
307	327	Domain	Zinc finger C2H2-type	IPR013087	PS00028
314	370	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
333	355	Domain	Zinc finger C2H2-type	IPR013087	PF00096
333	355	Domain	Zinc finger C2H2-type	IPR013087	SM00355
333	360	Domain	Zinc finger C2H2-type	IPR013087	PS50157
335	355	Domain	Zinc finger C2H2-type	IPR013087	PS00028
355	407	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
361	388	Domain	Zinc finger C2H2-type	IPR013087	PS50157
361	383	Domain	Zinc finger C2H2-type	IPR013087	PF00096
361	383	Domain	Zinc finger C2H2-type	IPR013087	SM00355
363	383	Domain	Zinc finger C2H2-type	IPR013087	PS00028
389	412	Domain	Zinc finger C2H2-type	IPR013087	SM00355
389	412	Domain	Zinc finger C2H2-type	IPR013087	PF00096
389	417	Domain	Zinc finger C2H2-type	IPR013087	PS50157
391	412	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001822	kidney development	Biological Process	IEA	GO_REF:0000107
GO:0003170	heart valve development	Biological Process	IEA	GO_REF:0000107
GO:0003279	cardiac septum development	Biological Process	IEA	GO_REF:0000107
GO:0060976	coronary vasculature development	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0016235	aggresome	Cellular Component	IDA	GO_REF:0000052
GO:0000976	transcription cis-regulatory region binding	Molecular Function	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:15629158
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:17714511
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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