SPOP

Details:

UniProt Entry: O43791
Gene: SPOP
Class: Other E3 Components
Family: Adaptor
Protein length: 374
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>O43791
MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ
RAYRFVQGKD WGFKKFIRRD FLLDEANGLL PDDKLTLFCE VSVVQDSVNI SGQNTMNMVK
VPECRLADEL GGLWENSRFT DCCLCVAGQE FQAHKAILAA RSPVFSAMFE HEMEESKKNR
VEINDVEPEV FKEMMCFIYT GKAPNLDKMA DDLLAAADKY ALERLKVMCE DALCSNLSVE
NAAEILILAD LHSADQLKTQ AVDFINYHAS DVLETSGWKS MVVSHPHLVA EAYRSLASAQ
CPFLGPPRKR LKQS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
29	166	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
31	161	Domain	MATH/TRAF domain	IPR002083	PS50144
36	142	Domain	MATH/TRAF domain	IPR002083	SM00061
65	161	Domain	MATH/TRAF domain	IPR002083	PF00917
175	291	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
180	295	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
193	296	Domain	BTB/POZ domain	IPR000210	PF00651
200	262	Domain	BTB/POZ domain	IPR000210	PS50097
200	297	Domain	BTB/POZ domain	IPR000210	SM00225
297	367	Domain	SPOP, C-terminal BACK domain	IPR034089	cd18518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:14528312
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030162	regulation of proteolysis	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-5635854
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IBA	GO_REF:0000033
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22632832
GO:0140678	molecular function inhibitor activity	Molecular Function	EXP	PMID:31624231

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