CIKS

>O43734
MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT
MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS
AVSEPASESV VGALPAEHQF SFMEKRNQWL VSQLSAASPD TGHDSDKSDQ SLPNASADSL
GGSQEMVQRP QPHRNRAGLD LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL
RSREFPQFEP QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ
PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ DQPHHQPPNR
AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL KTSNLPEELR KVFITYSMDT
AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI DIIKWMERYL RDKTVMIIVA ISPKYKQDVE
GAESQLDEDE HGLHTKYIHR MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS
WPKNKKNILL RLLREEEYVA PPRGPLPTLQ VVPL

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
409	550	Domain	SEFIR domain	IPR013568	PS51534
410	552	Domain	SEFIR domain	IPR013568	PF08357

GO term	Name	Ontology	Evidence	Reference
GO:0001783	B cell apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0006959	humoral immune response	Biological Process	IEA	GO_REF:0000107
GO:0038173	interleukin-17A-mediated signaling pathway	Biological Process	IDA	PMID:31376257
GO:1903882	negative regulation of interleukin-17-mediated signaling pathway	Biological Process	IDA	PMID:23042150
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0001768	establishment of T cell polarity	Biological Process	IEA	GO_REF:0000107
GO:0001782	B cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0001822	kidney development	Biological Process	IEA	GO_REF:0000107
GO:0002230	positive regulation of defense response to virus by host	Biological Process	IDA	PMID:23066157
GO:0002269	leukocyte activation involved in inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0002334	transitional two stage B cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0002344	B cell affinity maturation	Biological Process	IEA	GO_REF:0000107
GO:0002447	eosinophil mediated immunity	Biological Process	IEA	GO_REF:0000107
GO:0006606	protein import into nucleus	Biological Process	IEA	GO_REF:0000107
GO:0006954	inflammatory response	Biological Process	IEA	GO_REF:0000120
GO:0006955	immune response	Biological Process	IEA	GO_REF:0000107
GO:0007507	heart development	Biological Process	IEA	GO_REF:0000107
GO:0009410	response to xenobiotic stimulus	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0019724	B cell mediated immunity	Biological Process	IEA	GO_REF:0000107
GO:0023019	signal transduction involved in regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0023035	CD40 signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0030217	T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0034097	response to cytokine	Biological Process	IEA	GO_REF:0000107
GO:0034504	protein localization to nucleus	Biological Process	IEA	GO_REF:0000107
GO:0035556	intracellular signal transduction	Biological Process	NAS	PMID:10962033
GO:0042092	type 2 immune response	Biological Process	IEA	GO_REF:0000107
GO:0042110	T cell activation	Biological Process	IEA	GO_REF:0000107
GO:0042119	neutrophil activation	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043588	skin development	Biological Process	IEA	GO_REF:0000107
GO:0048255	mRNA stabilization	Biological Process	IEA	GO_REF:0000107
GO:0048535	lymph node development	Biological Process	IEA	GO_REF:0000107
GO:0048536	spleen development	Biological Process	IEA	GO_REF:0000107
GO:0070254	mucus secretion	Biological Process	IEA	GO_REF:0000107
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:19825828
GO:0071345	cellular response to cytokine stimulus	Biological Process	IEA	GO_REF:0000107
GO:0072538	T-helper 17 type immune response	Biological Process	IEA	GO_REF:0000107
GO:0097398	cellular response to interleukin-17	Biological Process	IEA	GO_REF:0000107
GO:0097400	interleukin-17-mediated signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0110012	protein localization to P-body	Biological Process	IEA	GO_REF:0000107
GO:1990959	eosinophil homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IC	PMID:20554964
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Cellular Component	IC	PMID:20554964
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000107
GO:0005102	signaling receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:12459498
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity