KLF4

>O43474
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH MKRLPPVLPG
RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN DLLDLDFILS NSLTHPPESV
AATVSSSASA SSSSSPSSSG PASAPSTCSF TYPIRAGNDP GVAPGGTGGG LLYGRESAPP
PTAPFNLADI NDVSPSGGFV AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS
EYGSPSVISV SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP
AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS FLPDQMQPQV
PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL ELMPPGSCMP EEPKPKRGRR
SWPRKRTATH TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH
YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
430	459	Domain	Zinc finger C2H2-type	IPR013087	PS50157
430	454	Domain	Zinc finger C2H2-type	IPR013087	SM00355
430	454	Domain	Zinc finger C2H2-type	IPR013087	PF00096
432	454	Domain	Zinc finger C2H2-type	IPR013087	PS00028
444	488	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
460	484	Domain	Zinc finger C2H2-type	IPR013087	PF00096
460	489	Domain	Zinc finger C2H2-type	IPR013087	PS50157
460	484	Domain	Zinc finger C2H2-type	IPR013087	SM00355
462	484	Domain	Zinc finger C2H2-type	IPR013087	PS00028
477	512	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
490	513	Domain	Zinc finger C2H2-type	IPR013087	PS50157
490	512	Domain	Zinc finger C2H2-type	IPR013087	SM00355
490	512	Domain	Zinc finger C2H2-type	IPR013087	PF00096
492	512	Domain	Zinc finger C2H2-type	IPR013087	PS00028

GO term	Name	Ontology	Evidence	Reference
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0006366	transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0032206	positive regulation of telomere maintenance	Biological Process	IDA	PMID:20629177
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0008285	negative regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0009913	epidermal cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0030855	epithelial cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0031077	post-embryonic camera-type eye development	Biological Process	IEA	GO_REF:0000107
GO:0032526	response to retinoic acid	Biological Process	IEA	GO_REF:0000107
GO:0035019	somatic stem cell population maintenance	Biological Process	IEA	GO_REF:0000107
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0048679	regulation of axon regeneration	Biological Process	IEA	GO_REF:0000107
GO:0048730	epidermis morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0120222	regulation of blastocyst development	Biological Process	IEA	GO_REF:0000107
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:20551324
GO:0002357	defense response to tumor cell	Biological Process	IMP	PMID:30429596
GO:0006351	DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0007500	mesodermal cell fate determination	Biological Process	TAS	PMID:8940147
GO:0008544	epidermis development	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010628	positive regulation of gene expression	Biological Process	IGI	PMID:22267480
GO:0010629	negative regulation of gene expression	Biological Process	IGI	PMID:22267480
GO:0014740	negative regulation of muscle hyperplasia	Biological Process	IEA	GO_REF:0000107
GO:0016525	negative regulation of angiogenesis	Biological Process	IDA	PMID:23867820
GO:0019827	stem cell population maintenance	Biological Process	ISS	GO_REF:0000024
GO:0030336	negative regulation of cell migration	Biological Process	IEA	GO_REF:0000107
GO:0032717	negative regulation of interleukin-8 production	Biological Process	IDA	PMID:20551324
GO:0034115	negative regulation of heterotypic cell-cell adhesion	Biological Process	IDA	PMID:20551324
GO:0035166	post-embryonic hemopoiesis	Biological Process	IMP	PMID:21539536
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:20551324
GO:0045429	positive regulation of nitric oxide biosynthetic process	Biological Process	IMP	PMID:22430140
GO:0045444	fat cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045595	regulation of cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0046985	positive regulation of hemoglobin biosynthetic process	Biological Process	IMP	PMID:21539536
GO:0048662	negative regulation of smooth muscle cell proliferation	Biological Process	IEA	GO_REF:0000120
GO:0050728	negative regulation of inflammatory response	Biological Process	TAS	PMID:20551324
GO:0051247	positive regulation of protein metabolic process	Biological Process	IGI	PMID:20551324
GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0060070	canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0060761	negative regulation of response to cytokine stimulus	Biological Process	IDA	PMID:20551324
GO:0061436	establishment of skin barrier	Biological Process	IEA	GO_REF:0000107
GO:0070301	cellular response to hydrogen peroxide	Biological Process	IEA	GO_REF:0000120
GO:0070373	negative regulation of ERK1 and ERK2 cascade	Biological Process	IEA	GO_REF:0000107
GO:0071300	cellular response to retinoic acid	Biological Process	IEA	GO_REF:0000120
GO:0071363	cellular response to growth factor stimulus	Biological Process	IDA	PMID:20551324
GO:0071499	cellular response to laminar fluid shear stress	Biological Process	IMP	PMID:22430140
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	Biological Process	IDA	PMID:20551324
GO:1902895	positive regulation of miRNA transcription	Biological Process	IDA	PMID:23867820
GO:1903672	positive regulation of sprouting angiogenesis	Biological Process	IGI	PMID:27431648
GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	Biological Process	IGI	PMID:22267480
GO:1990859	cellular response to endothelin	Biological Process	IEA	GO_REF:0000120
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Biological Process	IDA	PMID:23867820
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	Biological Process	IDA	PMID:20551324
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Biological Process	IDA	PMID:20551324
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000791	euchromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0005667	transcription regulator complex	Cellular Component	IEA	GO_REF:0000120
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000976	transcription cis-regulatory region binding	Molecular Function	ISS	GO_REF:0000024
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	Molecular Function	ISS	GO_REF:0000024
GO:0001221	transcription coregulator binding	Molecular Function	IEA	GO_REF:0000120
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000120
GO:0003690	double-stranded DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:19751731
GO:0008013	beta-catenin binding	Molecular Function	IEA	GO_REF:0000107
GO:0031490	chromatin DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0035014	phosphatidylinositol 3-kinase regulator activity	Molecular Function	IEA	GO_REF:0000107
GO:0042826	histone deacetylase binding	Molecular Function	IEA	GO_REF:0000120
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Molecular Function	ISS	GO_REF:0000024
GO:0106222	lncRNA binding	Molecular Function	IEA	GO_REF:0000107
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536
GO:1990841	promoter-specific chromatin binding	Molecular Function	IDA	PMID:27907090

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity