SIAH2

>O43255
MSRPSSTGPS ANKPCSKQPP PQPQHTPSPA APPAAATISA AGPGSSAVPA AAAVISGPGG
GGGAGPVSPQ HHELTSLFEC PVCFDYVLPP ILQCQAGHLV CNQCRQKLSC CPTCRGALTP
SIRNLAMEKV ASAVLFPCKY ATTGCSLTLH HTEKPEHEDI CEYRPYSCPC PGASCKWQGS
LEAVMSHLMH AHKSITTLQG EDIVFLATDI NLPGAVDWVM MQSCFGHHFM LVLEKQEKYE
GHQQFFAIVL LIGTRKQAEN FAYRLELNGN RRRLTWEATP RSIHDGVAAA IMNSDCLVFD
TAIAHLFADN GNLGINVTIS TCCP

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
14	321	Family	E3 ubiquitin-protein ligase SINA-like, animal	IPR004162	PTHR45877
67	126	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
80	115	Domain	Zinc finger, RING-type	IPR001841	PS50089
122	318	Domain	Seven-in-absentia protein, TRAF-like domain	IPR018121	PF03145
130	188	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
133	193	Domain	Zinc finger, SIAH-type	IPR013010	PS51081
189	321	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	IGI	PMID:12952940
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007264	small GTPase-mediated signal transduction	Biological Process	TAS	PMID:10207103
GO:0031396	regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0042752	regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000107
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP	PMID:21586138
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0060070	canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:1990000	amyloid fibril formation	Biological Process	IEA	GO_REF:0000117
GO:2001233	regulation of apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:21586138
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	IDA	PMID:21586138
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003714	transcription corepressor activity	Molecular Function	TAS	PMID:10207103
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:21586138
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9NS87	KIF15	Yes	Yes	No	No	—	No	E3-specific
Q9BSI4	TINF2	Yes	Yes	No	No	—	No	E3-specific
Q16656	NRF1	Yes	No	No	No	—	No	E3-specific
Q96KS0	EGLN2	Yes	Yes	No	No	—	No	Cluster-specific
O75376	NCOR1	Yes	Yes	No	No	23518348	EBI-6599095	E3-specific
Q9P212	PLCE1	Yes	Yes	No	No	—	No	Cluster-specific
Q9NRM7	LATS2	Yes	Yes	Yes	No	25438054	EBI-16129368	E3-specific
Q13625	ASPP2	Yes	Yes	No	No	—	No	E3-specific
O15379	HDAC3	Yes	Yes	No	No	—	No	E3-specific
P43146	DCC	Yes	Yes	No	No	—	No	Cluster-specific
Q16633	OBF1	Yes	Yes	No	No	—	No	Cluster-specific
Q9GZT9	EGLN1	Yes	Yes	No	No	—	No	Cluster-specific
Q92667	AKAP1	Yes	Yes	No	No	—	No	E3-specific
Q9BQF6	SENP7	Yes	No	No	No	—	No	E3-specific
O14974	MYPT1	Yes	Yes	No	No	—	No	E3-specific
Q9H6Z9	EGLN3	Yes	Yes	No	No	—	No	Cluster-specific